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B0FWC7

- COX1_AEDAE

UniProt

B0FWC7 - COX1_AEDAE

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Protein

Cytochrome c oxidase subunit 1

Gene
mt:CoI, COI, COX1
Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme A axial ligand) By similarityBy similarity
Metal bindingi239 – 2391Copper B By similarityBy similarity
Metal bindingi243 – 2431Copper B By similarityBy similarity
Metal bindingi289 – 2891Copper B By similarityBy similarity
Metal bindingi290 – 2901Copper B By similarityBy similarity
Metal bindingi375 – 3751Iron (heme A3 axial ligand) By similarityBy similarity
Metal bindingi377 – 3771Iron (heme A axial ligand) By similarityBy similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:mt:CoI
Synonyms:COI, COX1
Encoded oniMitochondrion
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Mitochondrion

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621Helical; Reviewed predictionAdd
BLAST
Transmembranei55 – 7521Helical; Reviewed predictionAdd
BLAST
Transmembranei101 – 11717Helical; Reviewed predictionAdd
BLAST
Transmembranei144 – 16421Helical; Reviewed predictionAdd
BLAST
Transmembranei182 – 20221Helical; Reviewed predictionAdd
BLAST
Transmembranei233 – 25321Helical; Reviewed predictionAdd
BLAST
Transmembranei267 – 28721Helical; Reviewed predictionAdd
BLAST
Transmembranei304 – 32421Helical; Reviewed predictionAdd
BLAST
Transmembranei337 – 35721Helical; Reviewed predictionAdd
BLAST
Transmembranei379 – 39921Helical; Reviewed predictionAdd
BLAST
Transmembranei415 – 43521Helical; Reviewed predictionAdd
BLAST
Transmembranei451 – 47121Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-SubCell
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000347262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki239 ↔ 2431'-histidyl-3'-tyrosine (His-Tyr) By similarityBy similarity

Structurei

3D structure databases

ProteinModelPortaliB0FWC7.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK02256.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0FWC7-1 [UniParc]FASTAAdd to Basket

« Hide

MSRQWLFSTN HKDIGTLYFI FGVWSGMVGT SLSILIRAEL SHPGMFIGND    50
QIYNVIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS 100
FWMLPPSLTL LLSSSMVENG AGTGWTVYPP LSSGTAHAGA SVDLAIFSLH 150
LAGISSILGA VNFITTVINM RSSGITLDRL PLFVWSVVIT AILLLLSLPV 200
LAGAITMLLT DRNLNTSFFD PIGGGDPILY QHLFWFFGHP EVYILILPGF 250
GMISHIITQE SGKKETFGTL GMIYAMLTIG LLGFIVWAHH MFTVGMDVDT 300
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ LTYSPALLWS LGFVFLFTVG 350
GLTGVVLANS SIDIVLHDTY YVVAHFHYVL SMGAVFAIMA GFIHWYPLLT 400
GMVMNPSWLK AQFSMMFIGV NLTFFPQHFL GLAGMPRRYS DFPDSYLTWN 450
IISSLGSTIS LFAVIFFLFI IWESMITQRT PSFPMQLSSS IEWYHTLPPA 500
EHTYSELPLL SSNF 514
Length:514
Mass (Da):56,966
Last modified:September 2, 2008 - v2
Checksum:i019CDFE533655F10
GO

Sequence cautioni

The sequence ABY51624.1 differs from that shown. Reason: Erroneous gene model prediction.

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711R → W in ABY51624. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU352212 Genomic DNA. Translation: ABY51624.1. Sequence problems.
AF380835 Genomic DNA. Translation: AAK56378.2.
AF390098 mRNA. Translation: AAK73349.2.
AY056596 Genomic DNA. Translation: AAL25639.1.
AY056597 Genomic DNA. Translation: AAL25640.1.
RefSeqiYP_001649163.1. NC_010241.1.

Genome annotation databases

GeneIDi5848241.
KEGGiaag:COX1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
EU352212 Genomic DNA. Translation: ABY51624.1 . Sequence problems.
AF380835 Genomic DNA. Translation: AAK56378.2 .
AF390098 mRNA. Translation: AAK73349.2 .
AY056596 Genomic DNA. Translation: AAL25639.1 .
AY056597 Genomic DNA. Translation: AAL25640.1 .
RefSeqi YP_001649163.1. NC_010241.1.

3D structure databases

ProteinModelPortali B0FWC7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5848241.
KEGGi aag:COX1.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

KOi K02256.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial genome of the Yellow fever mosquito - Aedes aegypti."
    Lobo N.F., Lovin D., DeBruyn B., Puiu D., Shumway M., Haas B., Nene V., Severson D.W.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12.
  2. "Complete mitochondrial DNA sequence and amino acid analysis of the cytochrome C oxidase subunit I (COI) from Aedes aegypti."
    Morlais I., Severson D.W.
    DNA Seq. 13:123-127(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 2-513.
    Strain: Formosus, Liverpool, Moyo-R and Red eye.
    Tissue: Midgut.

Entry informationi

Entry nameiCOX1_AEDAE
AccessioniPrimary (citable) accession number: B0FWC7
Secondary accession number(s): Q94PR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: September 3, 2014
This is version 41 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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