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B0FWC7

- COX1_AEDAE

UniProt

B0FWC7 - COX1_AEDAE

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Protein

Cytochrome c oxidase subunit 1

Gene

mt:CoI

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.Curated

Catalytic activityi

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.Curated

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi60 – 601Iron (heme A axial ligand)By similarity
Metal bindingi239 – 2391Copper BBy similarity
Metal bindingi243 – 2431Copper BBy similarity
Metal bindingi289 – 2891Copper BBy similarity
Metal bindingi290 – 2901Copper BBy similarity
Metal bindingi375 – 3751Iron (heme A3 axial ligand)By similarity
Metal bindingi377 – 3771Iron (heme A axial ligand)By similarity

GO - Molecular functioni

  1. cytochrome-c oxidase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro

GO - Biological processi

  1. aerobic respiration Source: InterPro
  2. oxidative phosphorylation Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Electron transport, Respiratory chain, Transport

Keywords - Ligandi

Copper, Heme, Iron, Metal-binding

Enzyme and pathway databases

UniPathwayiUPA00705.

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
Alternative name(s):
Cytochrome c oxidase polypeptide I
Gene namesi
Name:mt:CoIBy similarity
Synonyms:COIImported, COX1Imported
Encoded oniMitochondrionImported
OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifieri7159 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
ProteomesiUP000008820: Mitochondrion

Subcellular locationi

Mitochondrion inner membrane Sequence Analysis; Multi-pass membrane protein Sequence Analysis

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei16 – 3621HelicalSequence AnalysisAdd
BLAST
Transmembranei55 – 7521HelicalSequence AnalysisAdd
BLAST
Transmembranei101 – 11717HelicalSequence AnalysisAdd
BLAST
Transmembranei144 – 16421HelicalSequence AnalysisAdd
BLAST
Transmembranei182 – 20221HelicalSequence AnalysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence AnalysisAdd
BLAST
Transmembranei267 – 28721HelicalSequence AnalysisAdd
BLAST
Transmembranei304 – 32421HelicalSequence AnalysisAdd
BLAST
Transmembranei337 – 35721HelicalSequence AnalysisAdd
BLAST
Transmembranei379 – 39921HelicalSequence AnalysisAdd
BLAST
Transmembranei415 – 43521HelicalSequence AnalysisAdd
BLAST
Transmembranei451 – 47121HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. mitochondrial inner membrane Source: UniProtKB-KW
  3. respiratory chain Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000347262Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Cross-linki239 ↔ 2431'-histidyl-3'-tyrosine (His-Tyr)By similarity

Structurei

3D structure databases

ProteinModelPortaliB0FWC7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the heme-copper respiratory oxidase family.Sequence Analysis

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoidiB0FWC7.
KOiK02256.

Family and domain databases

Gene3Di1.20.210.10. 1 hit.
InterProiIPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view]
PANTHERiPTHR10422. PTHR10422. 1 hit.
PfamiPF00115. COX1. 1 hit.
[Graphical view]
PRINTSiPR01165. CYCOXIDASEI.
SUPFAMiSSF81442. SSF81442. 1 hit.
PROSITEiPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0FWC7-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRQWLFSTN HKDIGTLYFI FGVWSGMVGT SLSILIRAEL SHPGMFIGND
60 70 80 90 100
QIYNVIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS
110 120 130 140 150
FWMLPPSLTL LLSSSMVENG AGTGWTVYPP LSSGTAHAGA SVDLAIFSLH
160 170 180 190 200
LAGISSILGA VNFITTVINM RSSGITLDRL PLFVWSVVIT AILLLLSLPV
210 220 230 240 250
LAGAITMLLT DRNLNTSFFD PIGGGDPILY QHLFWFFGHP EVYILILPGF
260 270 280 290 300
GMISHIITQE SGKKETFGTL GMIYAMLTIG LLGFIVWAHH MFTVGMDVDT
310 320 330 340 350
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ LTYSPALLWS LGFVFLFTVG
360 370 380 390 400
GLTGVVLANS SIDIVLHDTY YVVAHFHYVL SMGAVFAIMA GFIHWYPLLT
410 420 430 440 450
GMVMNPSWLK AQFSMMFIGV NLTFFPQHFL GLAGMPRRYS DFPDSYLTWN
460 470 480 490 500
IISSLGSTIS LFAVIFFLFI IWESMITQRT PSFPMQLSSS IEWYHTLPPA
510
EHTYSELPLL SSNF
Length:514
Mass (Da):56,966
Last modified:September 2, 2008 - v2
Checksum:i019CDFE533655F10
GO

Sequence cautioni

The sequence ABY51624.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti171 – 1711R → W in ABY51624. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU352212 Genomic DNA. Translation: ABY51624.1. Sequence problems.
AF380835 Genomic DNA. Translation: AAK56378.2.
AF390098 mRNA. Translation: AAK73349.2.
AY056596 Genomic DNA. Translation: AAL25639.1.
AY056597 Genomic DNA. Translation: AAL25640.1.
RefSeqiYP_001649163.1. NC_010241.1.

Genome annotation databases

GeneIDi5848241.
KEGGiaag:COX1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU352212 Genomic DNA. Translation: ABY51624.1 . Sequence problems.
AF380835 Genomic DNA. Translation: AAK56378.2 .
AF390098 mRNA. Translation: AAK73349.2 .
AY056596 Genomic DNA. Translation: AAL25639.1 .
AY056597 Genomic DNA. Translation: AAL25640.1 .
RefSeqi YP_001649163.1. NC_010241.1.

3D structure databases

ProteinModelPortali B0FWC7.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5848241.
KEGGi aag:COX1.

Organism-specific databases

CTDi 4512.

Phylogenomic databases

InParanoidi B0FWC7.
KOi K02256.

Enzyme and pathway databases

UniPathwayi UPA00705 .

Family and domain databases

Gene3Di 1.20.210.10. 1 hit.
InterProi IPR000883. COX1.
IPR023615. Cyt_c_Oxase_su1_BS.
IPR023616. Cyt_c_Oxase_su1_dom.
[Graphical view ]
PANTHERi PTHR10422. PTHR10422. 1 hit.
Pfami PF00115. COX1. 1 hit.
[Graphical view ]
PRINTSi PR01165. CYCOXIDASEI.
SUPFAMi SSF81442. SSF81442. 1 hit.
PROSITEi PS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The mitochondrial genome of the Yellow fever mosquito - Aedes aegypti."
    Lobo N.F., Lovin D., DeBruyn B., Puiu D., Shumway M., Haas B., Nene V., Severson D.W.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: LVPib12Imported.
  2. "Complete mitochondrial DNA sequence and amino acid analysis of the cytochrome C oxidase subunit I (COI) from Aedes aegypti."
    Morlais I., Severson D.W.
    DNA Seq. 13:123-127(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 2-513.
    Strain: FormosusImported, LiverpoolImported, Moyo-R and Red eye.
    Tissue: MidgutImported.

Entry informationi

Entry nameiCOX1_AEDAE
AccessioniPrimary (citable) accession number: B0FWC7
Secondary accession number(s): Q94PR3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: October 29, 2014
This is version 43 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3