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Reviewed, UniProtKB/Swiss-Prot B0FWC7 (COX1_AEDAE)

Last modified June 16, 2009. Version 12. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Cytochrome c oxidase subunit 1
    EC=1.9.3.1
Alternative name(s):
    Cytochrome c oxidase polypeptide I
Gene names
Name: mt:CoI
Synonyms: COI, COX1
Encoded onMitochondrion
OrganismAedes aegypti (Yellowfever mosquito) (Culex aegypti)
Taxonomic identifier7159 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Endopterygota › Diptera › Nematocera › Culicoidea › Culicidae › Culicinae › Culicini › Aedes › Stegomyia

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Protein attributes

Sequence length514 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.

Catalytic activity

4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.

Pathway

Energy metabolism; oxidative phosphorylation.

Subcellular location

Mitochondrion inner membrane; Multi-pass membrane protein.

Sequence similarities

Belongs to the heme-copper respiratory oxidase family.

Sequence caution

The sequence ABY51624.1 differs from that shown. Reason: Erroneous gene model prediction.

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 514514Cytochrome c oxidase subunit 1
PRO_0000347262

Regions

Transmembrane16 – 3621 Potential
Transmembrane55 – 7521 Potential
Transmembrane101 – 11717 Potential
Transmembrane144 – 16421 Potential
Transmembrane182 – 20221 Potential
Transmembrane233 – 25321 Potential
Transmembrane267 – 28721 Potential
Transmembrane304 – 32421 Potential
Transmembrane337 – 35721 Potential
Transmembrane379 – 39921 Potential
Transmembrane415 – 43521 Potential
Transmembrane451 – 47121 Potential

Sites

Metal binding601Iron (heme A axial ligand) By similarity UniProtKB P98002
Metal binding2391Copper B By similarity UniProtKB P98002
Metal binding2431Copper B By similarity UniProtKB P98002
Metal binding2891Copper B By similarity UniProtKB P98002
Metal binding2901Copper B By similarity UniProtKB P98002
Metal binding3751Iron (heme A3 axial ligand) By similarity UniProtKB P98002
Metal binding3771Iron (heme A axial ligand) By similarity UniProtKB P98002

Amino acid modifications

Cross-link239 ↔ 2431'-histidyl-3'-tyrosine (His-Tyr) By similarity UniProtKB P98002

Experimental info

Sequence conflict1711R → W in ABY51624. Ref.1

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Sequences

Sequence LengthMass (Da)Tools
B0FWC7-1 [UniParc].

Last modified September 2, 2008. Version 2.
Checksum: 019CDFE533655F10

FASTA51456,966
        10         20         30         40         50         60 
MSRQWLFSTN HKDIGTLYFI FGVWSGMVGT SLSILIRAEL SHPGMFIGND QIYNVIVTAH 

        70         80         90        100        110        120 
AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS FWMLPPSLTL LLSSSMVENG 

       130        140        150        160        170        180 
AGTGWTVYPP LSSGTAHAGA SVDLAIFSLH LAGISSILGA VNFITTVINM RSSGITLDRL 

       190        200        210        220        230        240 
PLFVWSVVIT AILLLLSLPV LAGAITMLLT DRNLNTSFFD PIGGGDPILY QHLFWFFGHP 

       250        260        270        280        290        300 
EVYILILPGF GMISHIITQE SGKKETFGTL GMIYAMLTIG LLGFIVWAHH MFTVGMDVDT 

       310        320        330        340        350        360 
RAYFTSATMI IAVPTGIKIF SWLATLHGTQ LTYSPALLWS LGFVFLFTVG GLTGVVLANS 

       370        380        390        400        410        420 
SIDIVLHDTY YVVAHFHYVL SMGAVFAIMA GFIHWYPLLT GMVMNPSWLK AQFSMMFIGV 

       430        440        450        460        470        480 
NLTFFPQHFL GLAGMPRRYS DFPDSYLTWN IISSLGSTIS LFAVIFFLFI IWESMITQRT 

       490        500        510 
PSFPMQLSSS IEWYHTLPPA EHTYSELPLL SSNF

« Hide

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References

[1]"The mitochondrial genome of the Yellow fever mosquito - Aedes aegypti."
Lobo N.F., Lovin D., DeBruyn B., Puiu D., Shumway M., Haas B., Nene V., Severson D.W.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
Strain: Liverpool.
[2]"Complete mitochondrial DNA sequence and amino acid analysis of the cytochrome C oxidase subunit I (COI) from Aedes aegypti."
Morlais I., Severson D.W.
DNA Seq. 13:123-127(2002) [PubMed: 12180346] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 2-513.
Strain: Formosus, Liverpool, Moyo-R and Red eye.
Tissue: Midgut.

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Cross-references

Sequence databases

EU352212 Genomic DNA. Translation: ABY51624.1. Sequence problems.
AF380835 Genomic DNA. Translation: AAK56378.2.
AF390098 mRNA. Translation: AAK73349.2.
AY056596 Genomic DNA. Translation: AAL25639.1.
AY056597 Genomic DNA. Translation: AAL25640.1.
RefSeqYP_001649163.1.

3D structure databases

ModBaseSearch...

Genome annotation databases

GeneID5848241.
KEGGaag:COX1.

Family and domain databases

InterProIPR000883. Cyt_c_oxidase_su1.
[Graphical view]
Gene3DG3DSA:1.20.210.10. COX1. 1 hit.
PANTHERPTHR10422. COX1. 1 hit.
PfamPF00115. COX1. 1 hit.
[Graphical view]
PRINTSPR01165. CYCOXIDASEI.
PROSITEPS50855. COX1. 1 hit.
PS00077. COX1_CUB. 1 hit.
[Graphical view]
ProtoNetSearch...

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Entry information

Entry nameCOX1_AEDAE
AccessionPrimary (citable) accession number: B0FWC7
Secondary accession number(s): Q94PR3
Entry history
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: September 2, 2008
Last modified: June 16, 2009
This is version 12 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)

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Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents