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B0FWC7

- COX1_AEDAE

UniProt

B0FWC7 - COX1_AEDAE

Protein

Cytochrome c oxidase subunit 1

Gene

mt:CoI

Organism
Aedes aegypti (Yellowfever mosquito) (Culex aegypti)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 42 (01 Oct 2014)
      Sequence version 2 (02 Sep 2008)
      Previous versions | rss
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    Functioni

    Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.Curated

    Catalytic activityi

    4 ferrocytochrome c + O2 + 4 H+ = 4 ferricytochrome c + 2 H2O.Curated

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi60 – 601Iron (heme A axial ligand)By similarity
    Metal bindingi239 – 2391Copper BBy similarity
    Metal bindingi243 – 2431Copper BBy similarity
    Metal bindingi289 – 2891Copper BBy similarity
    Metal bindingi290 – 2901Copper BBy similarity
    Metal bindingi375 – 3751Iron (heme A3 axial ligand)By similarity
    Metal bindingi377 – 3771Iron (heme A axial ligand)By similarity

    GO - Molecular functioni

    1. cytochrome-c oxidase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    GO - Biological processi

    1. aerobic respiration Source: InterPro
    2. oxidative phosphorylation Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Biological processi

    Electron transport, Respiratory chain, Transport

    Keywords - Ligandi

    Copper, Heme, Iron, Metal-binding

    Enzyme and pathway databases

    UniPathwayiUPA00705.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome c oxidase subunit 1 (EC:1.9.3.1)
    Alternative name(s):
    Cytochrome c oxidase polypeptide I
    Gene namesi
    Name:mt:CoIBy similarity
    Synonyms:COIImported, COX1Imported
    Encoded oniMitochondrionImported
    OrganismiAedes aegypti (Yellowfever mosquito) (Culex aegypti)
    Taxonomic identifieri7159 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraEndopterygotaDipteraNematoceraCulicoideaCulicidaeCulicinaeAediniAedesStegomyia
    ProteomesiUP000008820: Mitochondrion

    Subcellular locationi

    Mitochondrion inner membrane Sequence Analysis; Multi-pass membrane protein Sequence Analysis

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. mitochondrial inner membrane Source: UniProtKB-SubCell
    3. respiratory chain Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane, Mitochondrion, Mitochondrion inner membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 514514Cytochrome c oxidase subunit 1PRO_0000347262Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Cross-linki239 ↔ 2431'-histidyl-3'-tyrosine (His-Tyr)By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliB0FWC7.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei16 – 3621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei55 – 7521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei101 – 11717HelicalSequence AnalysisAdd
    BLAST
    Transmembranei144 – 16421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei182 – 20221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei233 – 25321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei267 – 28721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei304 – 32421HelicalSequence AnalysisAdd
    BLAST
    Transmembranei337 – 35721HelicalSequence AnalysisAdd
    BLAST
    Transmembranei379 – 39921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei415 – 43521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei451 – 47121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the heme-copper respiratory oxidase family.Sequence Analysis

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    KOiK02256.

    Family and domain databases

    Gene3Di1.20.210.10. 1 hit.
    InterProiIPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view]
    PANTHERiPTHR10422. PTHR10422. 1 hit.
    PfamiPF00115. COX1. 1 hit.
    [Graphical view]
    PRINTSiPR01165. CYCOXIDASEI.
    SUPFAMiSSF81442. SSF81442. 1 hit.
    PROSITEiPS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0FWC7-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRQWLFSTN HKDIGTLYFI FGVWSGMVGT SLSILIRAEL SHPGMFIGND    50
    QIYNVIVTAH AFIMIFFMVM PIMIGGFGNW LVPLMLGAPD MAFPRMNNMS 100
    FWMLPPSLTL LLSSSMVENG AGTGWTVYPP LSSGTAHAGA SVDLAIFSLH 150
    LAGISSILGA VNFITTVINM RSSGITLDRL PLFVWSVVIT AILLLLSLPV 200
    LAGAITMLLT DRNLNTSFFD PIGGGDPILY QHLFWFFGHP EVYILILPGF 250
    GMISHIITQE SGKKETFGTL GMIYAMLTIG LLGFIVWAHH MFTVGMDVDT 300
    RAYFTSATMI IAVPTGIKIF SWLATLHGTQ LTYSPALLWS LGFVFLFTVG 350
    GLTGVVLANS SIDIVLHDTY YVVAHFHYVL SMGAVFAIMA GFIHWYPLLT 400
    GMVMNPSWLK AQFSMMFIGV NLTFFPQHFL GLAGMPRRYS DFPDSYLTWN 450
    IISSLGSTIS LFAVIFFLFI IWESMITQRT PSFPMQLSSS IEWYHTLPPA 500
    EHTYSELPLL SSNF 514
    Length:514
    Mass (Da):56,966
    Last modified:September 2, 2008 - v2
    Checksum:i019CDFE533655F10
    GO

    Sequence cautioni

    The sequence ABY51624.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti171 – 1711R → W in ABY51624. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU352212 Genomic DNA. Translation: ABY51624.1. Sequence problems.
    AF380835 Genomic DNA. Translation: AAK56378.2.
    AF390098 mRNA. Translation: AAK73349.2.
    AY056596 Genomic DNA. Translation: AAL25639.1.
    AY056597 Genomic DNA. Translation: AAL25640.1.
    RefSeqiYP_001649163.1. NC_010241.1.

    Genome annotation databases

    GeneIDi5848241.
    KEGGiaag:COX1.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    EU352212 Genomic DNA. Translation: ABY51624.1 . Sequence problems.
    AF380835 Genomic DNA. Translation: AAK56378.2 .
    AF390098 mRNA. Translation: AAK73349.2 .
    AY056596 Genomic DNA. Translation: AAL25639.1 .
    AY056597 Genomic DNA. Translation: AAL25640.1 .
    RefSeqi YP_001649163.1. NC_010241.1.

    3D structure databases

    ProteinModelPortali B0FWC7.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5848241.
    KEGGi aag:COX1.

    Organism-specific databases

    CTDi 4512.

    Phylogenomic databases

    KOi K02256.

    Enzyme and pathway databases

    UniPathwayi UPA00705 .

    Family and domain databases

    Gene3Di 1.20.210.10. 1 hit.
    InterProi IPR000883. COX1.
    IPR023615. Cyt_c_Oxase_su1_BS.
    IPR023616. Cyt_c_Oxase_su1_dom.
    [Graphical view ]
    PANTHERi PTHR10422. PTHR10422. 1 hit.
    Pfami PF00115. COX1. 1 hit.
    [Graphical view ]
    PRINTSi PR01165. CYCOXIDASEI.
    SUPFAMi SSF81442. SSF81442. 1 hit.
    PROSITEi PS50855. COX1. 1 hit.
    PS00077. COX1_CUB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The mitochondrial genome of the Yellow fever mosquito - Aedes aegypti."
      Lobo N.F., Lovin D., DeBruyn B., Puiu D., Shumway M., Haas B., Nene V., Severson D.W.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: LVPib12Imported.
    2. "Complete mitochondrial DNA sequence and amino acid analysis of the cytochrome C oxidase subunit I (COI) from Aedes aegypti."
      Morlais I., Severson D.W.
      DNA Seq. 13:123-127(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] OF 2-513.
      Strain: FormosusImported, LiverpoolImported, Moyo-R and Red eye.
      Tissue: MidgutImported.

    Entry informationi

    Entry nameiCOX1_AEDAE
    AccessioniPrimary (citable) accession number: B0FWC7
    Secondary accession number(s): Q94PR3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 2, 2008
    Last sequence update: September 2, 2008
    Last modified: October 1, 2014
    This is version 42 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3