B0FP48 (UPK3L_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Uroplakin-3b-like protein

Gene names

Name:	UPK3BL
Synonyms:	UPLP

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	263 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subcellular location	Membrane; Single-pass type I membrane protein Potential.
Sequence similarities	Belongs to the uroplakin-3 family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 33	33	Potential
	Chain	34 – 263	230	Uroplakin-3b-like protein		PRO_0000375087
Regions
	Topological domain	34 – 204	171	Extracellular Potential
	Transmembrane	205 – 225	21	Helical; Potential
	Topological domain	226 – 263	38	Cytoplasmic Potential
Amino acid modifications
	Glycosylation	51	1	N-linked (GlcNAc...) Potential
	Glycosylation	76	1	N-linked (GlcNAc...) Potential
	Glycosylation	91	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	B0FP48 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: CBA7419B03F7A57E	FASTA	263	28,385
	10 20 30 40 50 60 MDNSWRLGPA IGLSAGQSQL LVSLLLLLTR VQPGTDVAAP EHISYVPQLS NDTLAGRLTL 70 80 90 100 110 120 STFTLEQPLG QFSSHNISDL DTIWLVVALS NATQSFTAPR TNQDIPAPAN FSQRGYYLTL 130 140 150 160 170 180 RANRVLYQTR GQLHVLRVGN DTHCQPTKIG CNHPLPGPGP YRVKFLVMND EGPVAETKWS 190 200 210 220 230 240 SDTRLQQAQA LRAVPGPQSP GTVVIIAILS ILLAVLLTVL LAVLIYTCFN SCRSTSLSGP 250 260 EEAGSVRRYT THLAFSTPAE GAS

References

[1]	"Human uroplakin-like protein." Wistow G. Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Eye.

Cross-references

Sequence databases
EMBL GenBank DDBJ	EU341824 mRNA. Translation: ABY56115.1.
IPI	IPI00514244.
RefSeq	NP_001107875.1. NM_001114403.2.
UniGene	Hs.610255.
3D structure databases
ProteinModelPortal	B0FP48.
ModBase	Search...
PTM databases
PhosphoSite	B0FP48.
Proteomic databases
PaxDb	B0FP48.
PRIDE	B0FP48.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000340457; ENSP00000342938; ENSG00000267368.
GeneID	100134938.
KEGG	hsa:100134938.
UCSC	uc003uzw.2. human.
Organism-specific databases
CTD	100134938.
GeneCards	GC07M102222.
HGNC	HGNC:37278. UPK3BL.
HPA	HPA011403.
neXtProt	NX_B0FP48.
PharmGKB	PA165618441.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG26593.
HOGENOM	HOG000293265.
OMA	VRRYTTH.
OrthoDB	EOG4WM4VS.
Gene expression databases
ArrayExpress	B0FP48.
Bgee	B0FP48.
Genevestigator	B0FP48.
Family and domain databases
InterPro	IPR024831. Uroplakin-3. IPR024827. Uroplakin-3b-like. [Graphical view]
PANTHER	PTHR15446. PTHR15446. 1 hit. PTHR15446:SF2. PTHR15446:SF2. 1 hit.
ProtoNet	Search...
Other
GenomeRNAi	100134938.
NextBio	20774768.

Entry information

Entry name

UPK3L_HUMAN

Accession

Primary (citable) accession number: B0FP48

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 26, 2009
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.