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Protein
Submitted name:

Beta-1 adrenergic receptor

Gene

ADRB1

Organism
Cavia porcellus (Guinea pig)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptorUniRule annotationSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Beta-1 adrenergic receptorImported
Gene namesi
Name:ADRB1Imported
OrganismiCavia porcellus (Guinea pig)Imported
Taxonomic identifieri10141 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaHystricognathiCaviidaeCavia

Subcellular locationi

  • Cell membrane SAAS annotation; Multi-pass membrane protein SAAS annotation

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei57 – 8327HelicalSequence analysisAdd
BLAST
Transmembranei95 – 12127HelicalSequence analysisAdd
BLAST
Transmembranei133 – 15422HelicalSequence analysisAdd
BLAST
Transmembranei175 – 19925HelicalSequence analysisAdd
BLAST
Transmembranei223 – 24725HelicalSequence analysisAdd
BLAST
Transmembranei316 – 33621HelicalSequence analysisAdd
BLAST
Transmembranei348 – 36821HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membraneSAAS annotation, Membrane

Pathology & Biotechi

Chemistry

ChEMBLiCHEMBL5471.

Interactioni

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000017518.

Chemistry

BindingDBiB0FL73.

Structurei

3D structure databases

ProteinModelPortaliB0FL73.
SMRiB0FL73. Positions 57-255, 307-382.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini75 – 367293G_PROTEIN_RECEP_F1_2InterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.UniRule annotationSAAS annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000507. ADRB1_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00561. ADRENRGCB1AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0FL73-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGVLALGA SEPCNLSSTA PLPDGAATAA RLLVPASPPA SLLPPTSEGS
60 70 80 90 100
EPLSPQWTAG MGLLMVLIVL LIVAGNVLVI VAIAKTPRLQ TLTNLFIMSL
110 120 130 140 150
ASADLVMGLL VVPFGATIVV WGRWEYGSFF CELWTSVDVL CVTASIETLC
160 170 180 190 200
VIALDRYLAI TSPFRYQSLL TRARARVLVC TVWAISALVS FLPILMHWWR
210 220 230 240 250
AEGDEARRCY NDPKCCDFVT NRAYAIASSV VSFYVPLCIM AFVYLRVFRE
260 270 280 290 300
AQKQVKKIDS CERRFLGGPG RPPSPVPSPT PGSPRAATDP LANGRTSKRR
310 320 330 340 350
PSRLVALREQ KALKTLGIIM GVFTLCWLPF FLANVVKAFH RDLVPDRLFV
360 370 380 390 400
FFNWLGYANS AFNPIIYCRS PDFRKAFQRL LCCARRAARR RHTAHGGRPR
410 420 430 440 450
ASGCLARSGP PPSPGAASDE DEDAVGAAPP ARLLEPWAGC NGGAATADSD
460
WSLDEPGRAG FASESKV
Length:467
Mass (Da):50,524
Last modified:February 26, 2008 - v1
Checksum:i056FA73CE677C3F6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU332753 Genomic DNA. Translation: ABY49996.1.
RefSeqiNP_001166867.1. NM_001173396.1.

Genome annotation databases

GeneIDi100379595.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU332753 Genomic DNA. Translation: ABY49996.1.
RefSeqiNP_001166867.1. NM_001173396.1.

3D structure databases

ProteinModelPortaliB0FL73.
SMRiB0FL73. Positions 57-255, 307-382.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10141.ENSCPOP00000017518.

Chemistry

BindingDBiB0FL73.
ChEMBLiCHEMBL5471.

Protein family/group databases

GPCRDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi100379595.

Organism-specific databases

CTDi153.

Phylogenomic databases

eggNOGiKOG3656. Eukaryota.
ENOG410XRW9. LUCA.
HOGENOMiHOG000239242.
HOVERGENiHBG106962.

Family and domain databases

InterProiIPR002233. ADR_fam.
IPR000507. ADRB1_rcpt.
IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01103. ADRENERGICR.
PR00561. ADRENRGCB1AR.
PR00237. GPCRRHODOPSN.
SMARTiSM01381. 7TM_GPCR_Srsx. 1 hit.
[Graphical view]
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB0FL73_CAVPO
AccessioniPrimary (citable) accession number: B0FL73
Entry historyi
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 6, 2016
This is version 49 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.