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B0E6R0

- B0E6R0_ENTDS

UniProt

B0E6R0 - B0E6R0_ENTDS

Protein

Histone deacetylase

Gene

EDI_183810

Organism
Entamoeba dispar (strain ATCC PRA-260 / SAW760)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 31 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

    GO - Molecular functioni

    1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
    2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
    3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
    4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

    GO - Biological processi

    1. regulation of transcription, DNA-templated Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotation

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
    Gene namesi
    ORF Names:EDI_183810Imported
    OrganismiEntamoeba dispar (strain ATCC PRA-260 / SAW760)Imported
    Taxonomic identifieri370354 [NCBI]
    Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
    ProteomesiUP000008076: Unassembled WGS sequence

    Organism-specific databases

    EuPathDBiAmoebaDB:EDI_183810.

    Subcellular locationi

    Nucleus UniRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    NucleusUniRule annotation

    Structurei

    3D structure databases

    ProteinModelPortaliB0E6R0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    KOiK06067.

    Family and domain databases

    Gene3Di3.40.800.20. 1 hit.
    InterProiIPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view]
    PANTHERiPTHR10625. PTHR10625. 1 hit.
    PfamiPF00850. Hist_deacetyl. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSiPR01270. HDASUPER.
    PR01271. HISDACETLASE.

    Sequencei

    Sequence statusi: Complete.

    B0E6R0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRVCYFYDQ NVGEFDYGFG HPMKPLRNKL VHHLIMEYGI YKRLNIYKPW    50
    RATNEQMEMF HSKEYIDFLQ RVTPEMALQP HFKKSLEEFN FTDDCPVFEG 100
    LYPFVQTVVG SSLGCAMKIN ERAADICVNW SGGLHHAKKS QASGFCYIND 150
    IVCAILELLK VHSRVLYIDI DHHHGDGVEE AFKATNRVMT FSLHKYGDNY 200
    FPGTGDVDEI GIDEGKNYSI NVPLKDGIND EGYHRLFYPI IDRIMEVFQP 250
    SVVVMQCGAD SLNGDRLGFF NLSIQGHCDC MKYVKKFGLP MILVGGGGYT 300
    VSNTARCWCY ETAAACDLNI PDQIPINDYL EYYVPDMKIT ISTNPQMKNC 350
    NSRNYIEDIL NKVMIILEDV GNSNLPIVQF TNPPRIDEHT IEMQIDEDQQ 400
    DFNDVSNGFI RDIPLNIDSD EVIKMYTEPL PIYPKSKLFC TQNLKEFE 448
    Length:448
    Mass (Da):51,446
    Last modified:February 26, 2008 - v1
    Checksum:iD27A53FED078C439
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS547926 Genomic DNA. Translation: EDR29792.1.
    RefSeqiXP_001734073.1. XM_001734021.1.

    Genome annotation databases

    GeneIDi5878967.
    KEGGiedi:EDI_183810.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS547926 Genomic DNA. Translation: EDR29792.1 .
    RefSeqi XP_001734073.1. XM_001734021.1.

    3D structure databases

    ProteinModelPortali B0E6R0.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 5878967.
    KEGGi edi:EDI_183810.

    Organism-specific databases

    EuPathDBi AmoebaDB:EDI_183810.

    Phylogenomic databases

    KOi K06067.

    Family and domain databases

    Gene3Di 3.40.800.20. 1 hit.
    InterProi IPR000286. His_deacetylse.
    IPR003084. His_deacetylse_1.
    IPR023801. His_deacetylse_dom.
    [Graphical view ]
    PANTHERi PTHR10625. PTHR10625. 1 hit.
    Pfami PF00850. Hist_deacetyl. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
    PRINTSi PR01270. HDASUPER.
    PR01271. HISDACETLASE.
    ProtoNeti Search...

    Publicationsi

    1. "Annotation of Entamoeba dispar SAW760."
      Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.
      Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC PRA-260 / SAW760Imported.

    Entry informationi

    Entry nameiB0E6R0_ENTDS
    AccessioniPrimary (citable) accession number: B0E6R0
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 31 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3