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Protein

Histone deacetylase

Gene

EDI_183810

Organism
Entamoeba dispar (strain ATCC PRA-260 / SAW760)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei94SubstrateUniRule annotation1
Active sitei136Proton acceptorUniRule annotation1
Binding sitei144Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi171Divalent metal cationUniRule annotation1
Metal bindingi173Divalent metal cationUniRule annotation1
Metal bindingi260Divalent metal cationUniRule annotation1
Binding sitei299SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
ORF Names:EDI_183810Imported
OrganismiEntamoeba dispar (strain ATCC PRA-260 / SAW760)Imported
Taxonomic identifieri370354 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
Proteomesi
  • UP000008076 Componenti: Unassembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EDI_183810.

Subcellular locationi

  • Nucleus UniRule annotationSAAS annotation

GO - Cellular componenti

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Interactioni

Protein-protein interaction databases

STRINGi370354.XP_001734073.1.

Structurei

3D structure databases

ProteinModelPortaliB0E6R0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini21 – 313Hist_deacetylInterPro annotationAdd BLAST293

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342. Eukaryota.
COG0123. LUCA.
KOiK06067.
OMAiPRAWTHL.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiView protein in InterPro
IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiView protein in Pfam
PF00850. Hist_deacetyl. 1 hit.
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

B0E6R0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRVCYFYDQ NVGEFDYGFG HPMKPLRNKL VHHLIMEYGI YKRLNIYKPW
60 70 80 90 100
RATNEQMEMF HSKEYIDFLQ RVTPEMALQP HFKKSLEEFN FTDDCPVFEG
110 120 130 140 150
LYPFVQTVVG SSLGCAMKIN ERAADICVNW SGGLHHAKKS QASGFCYIND
160 170 180 190 200
IVCAILELLK VHSRVLYIDI DHHHGDGVEE AFKATNRVMT FSLHKYGDNY
210 220 230 240 250
FPGTGDVDEI GIDEGKNYSI NVPLKDGIND EGYHRLFYPI IDRIMEVFQP
260 270 280 290 300
SVVVMQCGAD SLNGDRLGFF NLSIQGHCDC MKYVKKFGLP MILVGGGGYT
310 320 330 340 350
VSNTARCWCY ETAAACDLNI PDQIPINDYL EYYVPDMKIT ISTNPQMKNC
360 370 380 390 400
NSRNYIEDIL NKVMIILEDV GNSNLPIVQF TNPPRIDEHT IEMQIDEDQQ
410 420 430 440
DFNDVSNGFI RDIPLNIDSD EVIKMYTEPL PIYPKSKLFC TQNLKEFE
Length:448
Mass (Da):51,446
Last modified:February 26, 2008 - v1
Checksum:iD27A53FED078C439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS547926 Genomic DNA. Translation: EDR29792.1.
RefSeqiXP_001734073.1. XM_001734021.1.

Genome annotation databases

EnsemblProtistsiEDR29792; EDR29792; EDI_183810.
GeneIDi5878967.
KEGGiedi:EDI_183810.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiB0E6R0_ENTDS
AccessioniPrimary (citable) accession number: B0E6R0
Entry historyiIntegrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: July 5, 2017
This is version 44 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported