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B0E6R0

- B0E6R0_ENTDS

UniProt

B0E6R0 - B0E6R0_ENTDS

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Protein

Histone deacetylase

Gene

EDI_183810

Organism
Entamoeba dispar (strain ATCC PRA-260 / SAW760)
Status
Unreviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

Hydrolysis of an N(6)-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotation

GO - Molecular functioni

  1. NAD-dependent histone deacetylase activity (H3-K14 specific) Source: UniProtKB-EC
  2. NAD-dependent histone deacetylase activity (H3-K18 specific) Source: UniProtKB-EC
  3. NAD-dependent histone deacetylase activity (H3-K9 specific) Source: UniProtKB-EC
  4. NAD-dependent histone deacetylase activity (H4-K16 specific) Source: UniProtKB-EC

GO - Biological processi

  1. regulation of transcription, DNA-templated Source: UniProtKB-KW
  2. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Chromatin regulatorUniRule annotation, HydrolaseUniRule annotationSAAS annotation

Keywords - Biological processi

Transcription, Transcription regulationUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotation (EC:3.5.1.98UniRule annotation)
Gene namesi
ORF Names:EDI_183810Imported
OrganismiEntamoeba dispar (strain ATCC PRA-260 / SAW760)Imported
Taxonomic identifieri370354 [NCBI]
Taxonomic lineageiEukaryotaAmoebozoaArchamoebaeEntamoebidaeEntamoeba
ProteomesiUP000008076: Unassembled WGS sequence

Organism-specific databases

EuPathDBiAmoebaDB:EDI_183810.

Subcellular locationi

Nucleus UniRule annotation

GO - Cellular componenti

  1. nucleus Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

NucleusUniRule annotation

Structurei

3D structure databases

ProteinModelPortaliB0E6R0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

KOiK06067.

Family and domain databases

Gene3Di3.40.800.20. 1 hit.
InterProiIPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view]
PANTHERiPTHR10625. PTHR10625. 1 hit.
PfamiPF00850. Hist_deacetyl. 1 hit.
[Graphical view]
PIRSFiPIRSF037913. His_deacetylse_1. 1 hit.
PRINTSiPR01270. HDASUPER.
PR01271. HISDACETLASE.

Sequencei

Sequence statusi: Complete.

B0E6R0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRVCYFYDQ NVGEFDYGFG HPMKPLRNKL VHHLIMEYGI YKRLNIYKPW
60 70 80 90 100
RATNEQMEMF HSKEYIDFLQ RVTPEMALQP HFKKSLEEFN FTDDCPVFEG
110 120 130 140 150
LYPFVQTVVG SSLGCAMKIN ERAADICVNW SGGLHHAKKS QASGFCYIND
160 170 180 190 200
IVCAILELLK VHSRVLYIDI DHHHGDGVEE AFKATNRVMT FSLHKYGDNY
210 220 230 240 250
FPGTGDVDEI GIDEGKNYSI NVPLKDGIND EGYHRLFYPI IDRIMEVFQP
260 270 280 290 300
SVVVMQCGAD SLNGDRLGFF NLSIQGHCDC MKYVKKFGLP MILVGGGGYT
310 320 330 340 350
VSNTARCWCY ETAAACDLNI PDQIPINDYL EYYVPDMKIT ISTNPQMKNC
360 370 380 390 400
NSRNYIEDIL NKVMIILEDV GNSNLPIVQF TNPPRIDEHT IEMQIDEDQQ
410 420 430 440
DFNDVSNGFI RDIPLNIDSD EVIKMYTEPL PIYPKSKLFC TQNLKEFE
Length:448
Mass (Da):51,446
Last modified:February 26, 2008 - v1
Checksum:iD27A53FED078C439
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS547926 Genomic DNA. Translation: EDR29792.1.
RefSeqiXP_001734073.1. XM_001734021.1.

Genome annotation databases

GeneIDi5878967.
KEGGiedi:EDI_183810.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS547926 Genomic DNA. Translation: EDR29792.1 .
RefSeqi XP_001734073.1. XM_001734021.1.

3D structure databases

ProteinModelPortali B0E6R0.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 5878967.
KEGGi edi:EDI_183810.

Organism-specific databases

EuPathDBi AmoebaDB:EDI_183810.

Phylogenomic databases

KOi K06067.

Family and domain databases

Gene3Di 3.40.800.20. 1 hit.
InterProi IPR000286. His_deacetylse.
IPR003084. His_deacetylse_1.
IPR023801. His_deacetylse_dom.
[Graphical view ]
PANTHERi PTHR10625. PTHR10625. 1 hit.
Pfami PF00850. Hist_deacetyl. 1 hit.
[Graphical view ]
PIRSFi PIRSF037913. His_deacetylse_1. 1 hit.
PRINTSi PR01270. HDASUPER.
PR01271. HISDACETLASE.
ProtoNeti Search...

Publicationsi

  1. "Annotation of Entamoeba dispar SAW760."
    Lorenzi H., Inman J., Schobel S., Amedeo P., Caler E.
    Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC PRA-260 / SAW760Imported.

Entry informationi

Entry nameiB0E6R0_ENTDS
AccessioniPrimary (citable) accession number: B0E6R0
Entry historyi
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: January 7, 2015
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.