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Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi556Zinc; catalyticPROSITE-ProRule annotation1
Active sitei557PROSITE-ProRule annotation1
Metal bindingi560Zinc; catalyticPROSITE-ProRule annotation1
Metal bindingi563Zinc; catalyticPROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase, Metalloprotease, Protease
LigandMetal-binding, Zinc

Protein family/group databases

MEROPSiM03.006

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:alpha-fg, MIP
ORF Names:LACBIDRAFT_181082
OrganismiLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Taxonomic identifieri486041 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesTricholomataceaeLaccaria
Proteomesi
  • UP000001194 Componenti: Unassembled WGS sequence

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transit peptidei1 – 42MitochondrionSequence analysisAdd BLAST42
ChainiPRO_000033858543 – 772Mitochondrial intermediate peptidaseAdd BLAST730

Interactioni

Protein-protein interaction databases

STRINGi486041.XP_001874001.1

Structurei

3D structure databases

ProteinModelPortaliB0CRC2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi485 – 488Poly-Asp4

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiKOG2090 Eukaryota
COG0339 LUCA
InParanoidiB0CRC2
KOiK01410
OrthoDBiEOG092C0JU2

Family and domain databases

CDDicd06457 M3A_MIP, 1 hit
Gene3Di1.10.1370.10, 2 hits
3.40.390.10, 2 hits
InterProiView protein in InterPro
IPR033851 M3A_MIP
IPR024079 MetalloPept_cat_dom_sf
IPR024077 Neurolysin/TOP_dom2
IPR001567 Pept_M3A_M3B
PANTHERiPTHR11804:SF5 PTHR11804:SF5, 1 hit
PfamiView protein in Pfam
PF01432 Peptidase_M3, 1 hit
PROSITEiView protein in PROSITE
PS00142 ZINC_PROTEASE, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0CRC2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFANSARNAL KKRPQNLQPF RFQGCLFSKR ANRPLTTKVQ HLIYASVDDK
60 70 80 90 100
ALVTLFDQPR STLRSPFATT GLFGHPSLTH PRALISLADA TVVRAQLLTD
110 120 130 140 150
RILRARESRT ELLRVVKNLD RLSDMLCGVI DLAELVRNAH PDRSWVDAAN
160 170 180 190 200
RAYETLCEFM NVLNTHVGLY EVLKAVLSDP SIVKTLGPEA HQTALIFWRD
210 220 230 240 250
FEKSAIDLPA EQRKKFVSLS SDILVLGRQF LEGANAPRPP ASIKPSQLSG
260 270 280 290 300
LKDKGMGVRL QLQAQFTQRD LQVYPGSLQA QMIMRSAPEE EPRRQVYLAA
310 320 330 340 350
NSSTPQQIEV LEKLLRTRAE LARLVGRDSF AHMTLDDKMA KTPDNVWNFL
360 370 380 390 400
DALMDHTKPF ARRALHTLSE RKQLHHGTSS LPIIQAWDRD FYCPPDPPAP
410 420 430 440 450
PIPLPPLTLG TVFMGLSRLF QHMYGISLRP ADSASGEVWH TDVQKLEVVD
460 470 480 490 500
QDQGIIGWIY ADLFARRGKA SGAAHYTVRC SRRTDDDDES SDGTVEGAEL
510 520 530 540 550
LIYESQEFEA VKRHRLPNQD GIYQLPLVVL LCEFARPTPS KGPTVLEWHE
560 570 580 590 600
VLTLFHEMGH AMHSMIGRTE YQNVAGTRCA TDFVEFPSIL MEHFLNSPTV
610 620 630 640 650
LSLFDVDGTS TVRHIGNHHN DPCHFIDTYS QILLAAVDQV YHSPAVLDPT
660 670 680 690 700
FDSTAELAKV HNTRGLIPYV PGTSFQTQFG HLYGYGATYY SYLLDRAIAS
710 720 730 740 750
RVWRNVFLDD PLDRETGEKF KCEVLRFGGG KDPWKMVSAL LDVPELSTGD
760 770
AEAMREIGRW KINSEIGVHG RH
Length:772
Mass (Da):86,856
Last modified:February 26, 2008 - v1
Checksum:i8E4B2FA8D81D1F7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS547091 Genomic DNA Translation: EDR15793.1
RefSeqiXP_001874001.1, XM_001873966.1

Genome annotation databases

EnsemblFungiiEDR15793; EDR15793; LACBIDRAFT_181082
GeneIDi6069018
KEGGilbc:LACBIDRAFT_181082

Similar proteinsi

Entry informationi

Entry nameiPMIP_LACBS
AccessioniPrimary (citable) accession number: B0CRC2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 26, 2008
Last modified: March 28, 2018
This is version 50 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health