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B0CRC2

- PMIP_LACBS

UniProt

B0CRC2 - PMIP_LACBS

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Protein
Mitochondrial intermediate peptidase
Gene
OCT1, alpha-fg, MIP, LACBIDRAFT_181082
Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Binds 1 zinc ion By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi556 – 5561Zinc; catalytic By similarity
Active sitei557 – 5571 By similarity
Metal bindingi560 – 5601Zinc; catalytic By similarity
Metal bindingi563 – 5631Zinc; catalytic By similarity

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Protein family/group databases

MEROPSiM03.006.

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:alpha-fg, MIP
ORF Names:LACBIDRAFT_181082
OrganismiLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Taxonomic identifieri486041 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesTricholomataceaeLaccaria
ProteomesiUP000001194: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrial matrix Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242Mitochondrion Reviewed prediction
Add
BLAST
Chaini43 – 772730Mitochondrial intermediate peptidase
PRO_0000338585Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi29883.JGI181082.

Structurei

3D structure databases

ProteinModelPortaliB0CRC2.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi485 – 4884Poly-Asp

Sequence similaritiesi

Belongs to the peptidase M3 family.

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0CRC2-1 [UniParc]FASTAAdd to Basket

« Hide

MFANSARNAL KKRPQNLQPF RFQGCLFSKR ANRPLTTKVQ HLIYASVDDK    50
ALVTLFDQPR STLRSPFATT GLFGHPSLTH PRALISLADA TVVRAQLLTD 100
RILRARESRT ELLRVVKNLD RLSDMLCGVI DLAELVRNAH PDRSWVDAAN 150
RAYETLCEFM NVLNTHVGLY EVLKAVLSDP SIVKTLGPEA HQTALIFWRD 200
FEKSAIDLPA EQRKKFVSLS SDILVLGRQF LEGANAPRPP ASIKPSQLSG 250
LKDKGMGVRL QLQAQFTQRD LQVYPGSLQA QMIMRSAPEE EPRRQVYLAA 300
NSSTPQQIEV LEKLLRTRAE LARLVGRDSF AHMTLDDKMA KTPDNVWNFL 350
DALMDHTKPF ARRALHTLSE RKQLHHGTSS LPIIQAWDRD FYCPPDPPAP 400
PIPLPPLTLG TVFMGLSRLF QHMYGISLRP ADSASGEVWH TDVQKLEVVD 450
QDQGIIGWIY ADLFARRGKA SGAAHYTVRC SRRTDDDDES SDGTVEGAEL 500
LIYESQEFEA VKRHRLPNQD GIYQLPLVVL LCEFARPTPS KGPTVLEWHE 550
VLTLFHEMGH AMHSMIGRTE YQNVAGTRCA TDFVEFPSIL MEHFLNSPTV 600
LSLFDVDGTS TVRHIGNHHN DPCHFIDTYS QILLAAVDQV YHSPAVLDPT 650
FDSTAELAKV HNTRGLIPYV PGTSFQTQFG HLYGYGATYY SYLLDRAIAS 700
RVWRNVFLDD PLDRETGEKF KCEVLRFGGG KDPWKMVSAL LDVPELSTGD 750
AEAMREIGRW KINSEIGVHG RH 772
Length:772
Mass (Da):86,856
Last modified:February 26, 2008 - v1
Checksum:i8E4B2FA8D81D1F7F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS547091 Genomic DNA. Translation: EDR15793.1.
RefSeqiXP_001874001.1. XM_001873966.1.

Genome annotation databases

GeneIDi6069018.
KEGGilbc:LACBIDRAFT_181082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
DS547091 Genomic DNA. Translation: EDR15793.1 .
RefSeqi XP_001874001.1. XM_001873966.1.

3D structure databases

ProteinModelPortali B0CRC2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 29883.JGI181082.

Protein family/group databases

MEROPSi M03.006.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6069018.
KEGGi lbc:LACBIDRAFT_181082.

Phylogenomic databases

eggNOGi COG0339.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis."
    Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F., Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J., Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.
    , Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A., DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P., Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P., Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R., Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H., Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M., Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U., Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J., Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A., Tuskan G., Grigoriev I.V.
    Nature 452:88-92(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S238N-H82 / ATCC MYA-4686.

Entry informationi

Entry nameiPMIP_LACBS
AccessioniPrimary (citable) accession number: B0CRC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 31 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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