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B0CRC2

- PMIP_LACBS

UniProt

B0CRC2 - PMIP_LACBS

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 32 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane By similarity.By similarity

    Catalytic activityi

    Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

    Cofactori

    Binds 1 zinc ion.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi556 – 5561Zinc; catalyticPROSITE-ProRule annotation
    Active sitei557 – 5571PROSITE-ProRule annotation
    Metal bindingi560 – 5601Zinc; catalyticPROSITE-ProRule annotation
    Metal bindingi563 – 5631Zinc; catalyticPROSITE-ProRule annotation

    GO - Molecular functioni

    1. metal ion binding Source: UniProtKB-KW
    2. metalloendopeptidase activity Source: InterPro

    Keywords - Molecular functioni

    Hydrolase, Metalloprotease, Protease

    Keywords - Ligandi

    Metal-binding, Zinc

    Protein family/group databases

    MEROPSiM03.006.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mitochondrial intermediate peptidase (EC:3.4.24.59)
    Short name:
    MIP
    Alternative name(s):
    Octapeptidyl aminopeptidase
    Gene namesi
    Name:OCT1
    Synonyms:alpha-fg, MIP
    ORF Names:LACBIDRAFT_181082
    OrganismiLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
    Taxonomic identifieri486041 [NCBI]
    Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesTricholomataceaeLaccaria
    ProteomesiUP000001194: Unassembled WGS sequence

    Subcellular locationi

    Mitochondrion matrix By similarity

    GO - Cellular componenti

    1. mitochondrial matrix Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Mitochondrion

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transit peptidei1 – 4242MitochondrionSequence AnalysisAdd
    BLAST
    Chaini43 – 772730Mitochondrial intermediate peptidasePRO_0000338585Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi29883.JGI181082.

    Structurei

    3D structure databases

    ProteinModelPortaliB0CRC2.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi485 – 4884Poly-Asp

    Sequence similaritiesi

    Belongs to the peptidase M3 family.Curated

    Keywords - Domaini

    Transit peptide

    Phylogenomic databases

    eggNOGiCOG0339.
    KOiK01410.
    OrthoDBiEOG71GB4R.

    Family and domain databases

    Gene3Di1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProiIPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view]
    PfamiPF01432. Peptidase_M3. 1 hit.
    [Graphical view]
    PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B0CRC2-1 [UniParc]FASTAAdd to Basket

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    MFANSARNAL KKRPQNLQPF RFQGCLFSKR ANRPLTTKVQ HLIYASVDDK    50
    ALVTLFDQPR STLRSPFATT GLFGHPSLTH PRALISLADA TVVRAQLLTD 100
    RILRARESRT ELLRVVKNLD RLSDMLCGVI DLAELVRNAH PDRSWVDAAN 150
    RAYETLCEFM NVLNTHVGLY EVLKAVLSDP SIVKTLGPEA HQTALIFWRD 200
    FEKSAIDLPA EQRKKFVSLS SDILVLGRQF LEGANAPRPP ASIKPSQLSG 250
    LKDKGMGVRL QLQAQFTQRD LQVYPGSLQA QMIMRSAPEE EPRRQVYLAA 300
    NSSTPQQIEV LEKLLRTRAE LARLVGRDSF AHMTLDDKMA KTPDNVWNFL 350
    DALMDHTKPF ARRALHTLSE RKQLHHGTSS LPIIQAWDRD FYCPPDPPAP 400
    PIPLPPLTLG TVFMGLSRLF QHMYGISLRP ADSASGEVWH TDVQKLEVVD 450
    QDQGIIGWIY ADLFARRGKA SGAAHYTVRC SRRTDDDDES SDGTVEGAEL 500
    LIYESQEFEA VKRHRLPNQD GIYQLPLVVL LCEFARPTPS KGPTVLEWHE 550
    VLTLFHEMGH AMHSMIGRTE YQNVAGTRCA TDFVEFPSIL MEHFLNSPTV 600
    LSLFDVDGTS TVRHIGNHHN DPCHFIDTYS QILLAAVDQV YHSPAVLDPT 650
    FDSTAELAKV HNTRGLIPYV PGTSFQTQFG HLYGYGATYY SYLLDRAIAS 700
    RVWRNVFLDD PLDRETGEKF KCEVLRFGGG KDPWKMVSAL LDVPELSTGD 750
    AEAMREIGRW KINSEIGVHG RH 772
    Length:772
    Mass (Da):86,856
    Last modified:February 26, 2008 - v1
    Checksum:i8E4B2FA8D81D1F7F
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS547091 Genomic DNA. Translation: EDR15793.1.
    RefSeqiXP_001874001.1. XM_001873966.1.

    Genome annotation databases

    GeneIDi6069018.
    KEGGilbc:LACBIDRAFT_181082.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    DS547091 Genomic DNA. Translation: EDR15793.1 .
    RefSeqi XP_001874001.1. XM_001873966.1.

    3D structure databases

    ProteinModelPortali B0CRC2.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 29883.JGI181082.

    Protein family/group databases

    MEROPSi M03.006.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6069018.
    KEGGi lbc:LACBIDRAFT_181082.

    Phylogenomic databases

    eggNOGi COG0339.
    KOi K01410.
    OrthoDBi EOG71GB4R.

    Family and domain databases

    Gene3Di 1.10.1370.10. 2 hits.
    1.20.1050.40. 1 hit.
    3.40.390.10. 2 hits.
    InterProi IPR024079. MetalloPept_cat_dom.
    IPR024077. Neurolysin/TOP_dom2.
    IPR024080. Neurolysin/TOP_N.
    IPR001567. Pept_M3A_M3B.
    [Graphical view ]
    Pfami PF01432. Peptidase_M3. 1 hit.
    [Graphical view ]
    PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis."
      Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F., Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J., Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.
      , Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A., DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P., Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P., Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R., Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H., Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M., Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U., Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J., Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A., Tuskan G., Grigoriev I.V.
      Nature 452:88-92(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: S238N-H82 / ATCC MYA-4686.

    Entry informationi

    Entry nameiPMIP_LACBS
    AccessioniPrimary (citable) accession number: B0CRC2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 10, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 32 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programFungal Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Peptidase families
      Classification of peptidase families and list of entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3