Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

B0CRC2

- PMIP_LACBS

UniProt

B0CRC2 - PMIP_LACBS

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Mitochondrial intermediate peptidase

Gene

OCT1

Organism
Laccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).By similarity

Catalytic activityi

Release of an N-terminal octapeptide as second stage of processing of some proteins imported into the mitochondrion.

Cofactori

Zn2+By similarityNote: Binds 1 zinc ion.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi556 – 5561Zinc; catalyticPROSITE-ProRule annotation
Active sitei557 – 5571PROSITE-ProRule annotation
Metal bindingi560 – 5601Zinc; catalyticPROSITE-ProRule annotation
Metal bindingi563 – 5631Zinc; catalyticPROSITE-ProRule annotation

GO - Molecular functioni

  1. metal ion binding Source: UniProtKB-KW
  2. metalloendopeptidase activity Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Metalloprotease, Protease

Keywords - Ligandi

Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial intermediate peptidase (EC:3.4.24.59)
Short name:
MIP
Alternative name(s):
Octapeptidyl aminopeptidase
Gene namesi
Name:OCT1
Synonyms:alpha-fg, MIP
ORF Names:LACBIDRAFT_181082
OrganismiLaccaria bicolor (strain S238N-H82 / ATCC MYA-4686) (Bicoloured deceiver) (Laccaria laccata var. bicolor)
Taxonomic identifieri486041 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaBasidiomycotaAgaricomycotinaAgaricomycetesAgaricomycetidaeAgaricalesTricholomataceaeLaccaria
ProteomesiUP000001194: Unassembled WGS sequence

Subcellular locationi

Mitochondrion matrix By similarity

GO - Cellular componenti

  1. mitochondrion Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Mitochondrion

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transit peptidei1 – 4242MitochondrionSequence AnalysisAdd
BLAST
Chaini43 – 772730Mitochondrial intermediate peptidasePRO_0000338585Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi29883.JGI181082.

Structurei

3D structure databases

ProteinModelPortaliB0CRC2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi485 – 4884Poly-Asp

Sequence similaritiesi

Belongs to the peptidase M3 family.Curated

Keywords - Domaini

Transit peptide

Phylogenomic databases

eggNOGiCOG0339.
InParanoidiB0CRC2.
KOiK01410.
OrthoDBiEOG71GB4R.

Family and domain databases

Gene3Di1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProiIPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view]
PfamiPF01432. Peptidase_M3. 1 hit.
[Graphical view]
PROSITEiPS00142. ZINC_PROTEASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0CRC2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MFANSARNAL KKRPQNLQPF RFQGCLFSKR ANRPLTTKVQ HLIYASVDDK
60 70 80 90 100
ALVTLFDQPR STLRSPFATT GLFGHPSLTH PRALISLADA TVVRAQLLTD
110 120 130 140 150
RILRARESRT ELLRVVKNLD RLSDMLCGVI DLAELVRNAH PDRSWVDAAN
160 170 180 190 200
RAYETLCEFM NVLNTHVGLY EVLKAVLSDP SIVKTLGPEA HQTALIFWRD
210 220 230 240 250
FEKSAIDLPA EQRKKFVSLS SDILVLGRQF LEGANAPRPP ASIKPSQLSG
260 270 280 290 300
LKDKGMGVRL QLQAQFTQRD LQVYPGSLQA QMIMRSAPEE EPRRQVYLAA
310 320 330 340 350
NSSTPQQIEV LEKLLRTRAE LARLVGRDSF AHMTLDDKMA KTPDNVWNFL
360 370 380 390 400
DALMDHTKPF ARRALHTLSE RKQLHHGTSS LPIIQAWDRD FYCPPDPPAP
410 420 430 440 450
PIPLPPLTLG TVFMGLSRLF QHMYGISLRP ADSASGEVWH TDVQKLEVVD
460 470 480 490 500
QDQGIIGWIY ADLFARRGKA SGAAHYTVRC SRRTDDDDES SDGTVEGAEL
510 520 530 540 550
LIYESQEFEA VKRHRLPNQD GIYQLPLVVL LCEFARPTPS KGPTVLEWHE
560 570 580 590 600
VLTLFHEMGH AMHSMIGRTE YQNVAGTRCA TDFVEFPSIL MEHFLNSPTV
610 620 630 640 650
LSLFDVDGTS TVRHIGNHHN DPCHFIDTYS QILLAAVDQV YHSPAVLDPT
660 670 680 690 700
FDSTAELAKV HNTRGLIPYV PGTSFQTQFG HLYGYGATYY SYLLDRAIAS
710 720 730 740 750
RVWRNVFLDD PLDRETGEKF KCEVLRFGGG KDPWKMVSAL LDVPELSTGD
760 770
AEAMREIGRW KINSEIGVHG RH
Length:772
Mass (Da):86,856
Last modified:February 26, 2008 - v1
Checksum:i8E4B2FA8D81D1F7F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS547091 Genomic DNA. Translation: EDR15793.1.
RefSeqiXP_001874001.1. XM_001873966.1.

Genome annotation databases

GeneIDi6069018.
KEGGilbc:LACBIDRAFT_181082.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DS547091 Genomic DNA. Translation: EDR15793.1 .
RefSeqi XP_001874001.1. XM_001873966.1.

3D structure databases

ProteinModelPortali B0CRC2.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 29883.JGI181082.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6069018.
KEGGi lbc:LACBIDRAFT_181082.

Phylogenomic databases

eggNOGi COG0339.
InParanoidi B0CRC2.
KOi K01410.
OrthoDBi EOG71GB4R.

Family and domain databases

Gene3Di 1.10.1370.10. 2 hits.
1.20.1050.40. 1 hit.
3.40.390.10. 2 hits.
InterProi IPR024079. MetalloPept_cat_dom.
IPR024077. Neurolysin/TOP_dom2.
IPR024080. Neurolysin/TOP_N.
IPR001567. Pept_M3A_M3B.
[Graphical view ]
Pfami PF01432. Peptidase_M3. 1 hit.
[Graphical view ]
PROSITEi PS00142. ZINC_PROTEASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Laccaria bicolor provides insights into mycorrhizal symbiosis."
    Martin F., Aerts A., Ahren D., Brun A., Danchin E.G.J., Duchaussoy F., Gibon J., Kohler A., Lindquist E., Pereda V., Salamov A., Shapiro H.J., Wuyts J., Blaudez D., Buee M., Brokstein P., Canbaeck B., Cohen D.
    , Courty P.E., Coutinho P.M., Delaruelle C., Detter J.C., Deveau A., DiFazio S., Duplessis S., Fraissinet-Tachet L., Lucic E., Frey-Klett P., Fourrey C., Feussner I., Gay G., Grimwood J., Hoegger P.J., Jain P., Kilaru S., Labbe J., Lin Y.C., Legue V., Le Tacon F., Marmeisse R., Melayah D., Montanini B., Muratet M., Nehls U., Niculita-Hirzel H., Oudot-Le Secq M.P., Peter M., Quesneville H., Rajashekar B., Reich M., Rouhier N., Schmutz J., Yin T., Chalot M., Henrissat B., Kuees U., Lucas S., Van de Peer Y., Podila G.K., Polle A., Pukkila P.J., Richardson P.M., Rouze P., Sanders I.R., Stajich J.E., Tunlid A., Tuskan G., Grigoriev I.V.
    Nature 452:88-92(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: S238N-H82 / ATCC MYA-4686.

Entry informationi

Entry nameiPMIP_LACBS
AccessioniPrimary (citable) accession number: B0CRC2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: February 26, 2008
Last modified: November 26, 2014
This is version 34 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Peptidase families
    Classification of peptidase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3