Reviewed, UniProtKB/Swiss-Prot B0CM52 (GMPPA_PAPAN)

Names and origin

Protein names

Recommended name:
    Mannose-1-phosphate guanyltransferase alpha
    EC=2.7.7.13
Alternative name(s):
    GTP-mannose-1-phosphate guanylyltransferase alpha
    GDP-mannose pyrophosphorylase A

Gene names

Name:

GMPPA

Organism

Papio anubis (Olive baboon)

Taxonomic identifier

9555 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Cercopithecidae › Cercopithecinae › Papio

Protein attributes

Sequence length	420 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose.
Pathway	Nucleotide-sugar biosynthesis; GDP-alpha-D-mannose biosynthesis; GDP-alpha-D-mannose from alpha-D-mannose 1-phosphate (GTP route): step 1/1.
Sequence similarities	Belongs to the transferase hexapeptide repeat family.

Ontologies

Keywords
Ligand	GTP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Gene Ontology (GO)
Biological process	biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW mannose-1-phosphate guanylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 420	420	Mannose-1-phosphate guanyltransferase alpha		PRO_0000327874

Sequences

	Sequence		Length	Mass (Da)
	B0CM52-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 72BC24BC15C9C9A1	FASTA	420	46,288
	10 20 30 40 50 60 MLKAVILIGG PQKGTRFRPL SFEVPKPLFP VAGVPMIQHH IEACAQVPGM QEILLIGFYQ 70 80 90 100 110 120 PDEPLTQFLE AAQQEFNLPV RYLQEFAPLG TGGGLYHFRD QILAGSPEAF FVLNADVCSD 130 140 150 160 170 180 FPLSAMLEAH RRQRHPFLLL GTTANRTQSL NYGCIVENPQ THEVLHYVEK PSTFISDIIN 190 200 210 220 230 240 CGIYLFSPEA LKPLRDVFQR NQQDGQLEDS PGLWPGAGTI RLEQDVFSAL AGQGQIYVHL 250 260 270 280 290 300 TDGIWSQIKS AGSALYASRL YLSRYQDTHP ERLAKHTPGG PRIRGNVYIH PTAKVAPSAV 310 320 330 340 350 360 LGPNVSIGKG VTVGEGVRLR ESIVLHGATL QEHTCVLHSI VGWGSTVGRW ARVEGTPNDP 370 380 390 400 410 420 NPNDPRARMD SESLFKDGKL LPAITILGCR VRIPAEVLIL NSIVLPHKEL SRSFTNQIIL

References

[1]

"NISC comparative sequencing initiative." Antonellis A., Benjamin B., Blakesley R.W., Bouffard G.G., Brinkley C., Brooks S., Chu G., Chub I., Coleman H., Fuksenko T., Gestole M., Gregory M., Guan X., Gupta J., Gurson N., Han E., Han J., Hansen N. , Hargrove A., Hines-Harris K., Ho S.-L., Hu P., Hunter G., Hurle B., Idol J.R., Johnson T., Knight E., Kwong P., Lee-Lin S.-Q., Legaspi R., Madden M., Maduro Q.L., Maduro V.B., Margulies E.H., Masiello C., Maskeri B., McDowell J., Merkulov G., Montemayor C., Mullikin J.C., Park M., Prasad A., Ramsahoye C., Reddix-Dugue N., Riebow N., Schandler K., Schueler M.G., Sison C., Smith L., Stantripop S., Thomas J.W., Thomas P.J., Tsipouri V., Young A., Green E.D. Submitted (JAN-2008) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	DP000550 Genomic DNA. Translation: ABY67209.1.
3D structure databases
ModBase	Search...
Enzyme and pathway databases
BRENDA	2.7.7.13. 67047.
Family and domain databases
InterPro	IPR001451. Hexapep_transf. IPR018357. Hexapep_transf_CS. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00132. Hexapep. 4 hits. PF00483. NTP_transferase. 1 hit. [Graphical view]
PROSITE	PS00101. HEXAPEP_TRANSFERASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GMPPA_PAPAN

Accession

Primary (citable) accession number: B0CM52

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 8, 2008
Last sequence update:	February 26, 2008
Last modified:	September 22, 2009
This is version 12 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)