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B0CL13

- B0CL13_BRUSI

UniProt

B0CL13 - B0CL13_BRUSI

Protein

Probable cytosol aminopeptidase

Gene

pepA

Organism
Brucella suis (strain ATCC 23445 / NCTC 10510)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides.UniRule annotationSAAS annotation

    Catalytic activityi

    Release of an N-terminal amino acid, Xaa-|-Yaa-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Yaa may be Pro. Amino acid amides and methyl esters are also readily hydrolyzed, but rates on arylamides are exceedingly low.UniRule annotationSAAS annotation
    Release of an N-terminal amino acid, preferentially leucine, but not glutamic or aspartic acids.UniRule annotation

    Cofactori

    Binds 2 manganese ions per subunit.UniRule annotation

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi263 – 2631Manganese 2UniRule annotation
    Metal bindingi268 – 2681Manganese 1UniRule annotation
    Metal bindingi268 – 2681Manganese 2UniRule annotation
    Active sitei275 – 2751UniRule annotation
    Metal bindingi286 – 2861Manganese 2UniRule annotation
    Metal bindingi345 – 3451Manganese 1UniRule annotation
    Metal bindingi347 – 3471Manganese 1UniRule annotation
    Metal bindingi347 – 3471Manganese 2UniRule annotation
    Active sitei349 – 3491UniRule annotation

    GO - Molecular functioni

    1. aminopeptidase activity Source: UniProtKB-HAMAP
    2. manganese ion binding Source: UniProtKB-HAMAP
    3. metalloexopeptidase activity Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    AminopeptidaseUniRule annotationSAAS annotationImported, Hydrolase, Protease

    Keywords - Ligandi

    ManganeseUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciBSUI470137:GJIC-710-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable cytosol aminopeptidaseUniRule annotation
    Alternative name(s):
    Leucine aminopeptidaseUniRule annotation
    Leucyl aminopeptidaseUniRule annotation
    Gene namesi
    Name:pepAUniRule annotationImported
    Ordered Locus Names:BSUIS_A0717Imported
    OrganismiBrucella suis (strain ATCC 23445 / NCTC 10510)Imported
    Taxonomic identifieri470137 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
    ProteomesiUP000008545: Chromosome I

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Protein-protein interaction databases

    STRINGi470137.BSUIS_A0717.

    Structurei

    3D structure databases

    ProteinModelPortaliB0CL13.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the peptidase M17 family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0260.
    HOGENOMiHOG000243129.
    KOiK01255.
    OMAiDSQFADM.
    OrthoDBiEOG6FV8B3.

    Family and domain databases

    HAMAPiMF_00181. Cytosol_peptidase_M17.
    InterProiIPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view]
    PfamiPF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view]
    PRINTSiPR00481. LAMNOPPTDASE.
    PROSITEiPS00631. CYTOSOL_AP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0CL13-1 [UniParc]FASTAAdd to Basket

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    MSKRPSISFS EFEVPQKGVA VVLVAKGGGF ADEAAKAVGG AEKIARIADI    50
    SGFTGALGKT AEAIETTPAG VEKIVLVGVG EPGKLGNDDW LKIGGAAFSQ 100
    IGNAERVTLT LALPETTIAG DEAADVALGM VLRSYKFDRY KTRKSEENGE 150
    PKHAAKITIC VADTHSARKT FEVAEAVADG VIQARNLVNE PANILGPVEF 200
    AEEAEKLEKL GVKVEVLGEK ELKKLGMGAL LGVAQGSVRP PRLVVMEWHG 250
    AKGKEKPIAF VGKGVVFDTG GISIKPAANM EDMKGDMGGA AAVTGLMRAL 300
    AGRKAKVNAI GVIGLVENMP DGNAQRPGDI VTSMSGQTIE VINTDAEGRL 350
    VLADALHYTN DRFKPRFIIN LATLTGAVMV ALGQYHAGLF SNDDELADQL 400
    YDAGQSTGEK LWRLPLGTEY DKMIDSKFAD MKNSAGRYGG SITAAQFLKR 450
    FVGETPWAHL DVAGTAMGSP ANEYNQSWAS GFGVRLLDRL VRDQFES 497
    Length:497
    Mass (Da):52,576
    Last modified:February 26, 2008 - v1
    Checksum:i287DD9E0C90DC3AC
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000911 Genomic DNA. Translation: ABY37793.1.
    RefSeqiYP_001627363.1. NC_010169.1.

    Genome annotation databases

    EnsemblBacteriaiABY37793; ABY37793; BSUIS_A0717.
    GeneIDi5839178.
    KEGGibmt:BSUIS_A0717.
    PATRICi17868972. VBIBruSui83806_2289.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000911 Genomic DNA. Translation: ABY37793.1 .
    RefSeqi YP_001627363.1. NC_010169.1.

    3D structure databases

    ProteinModelPortali B0CL13.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 470137.BSUIS_A0717.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY37793 ; ABY37793 ; BSUIS_A0717 .
    GeneIDi 5839178.
    KEGGi bmt:BSUIS_A0717.
    PATRICi 17868972. VBIBruSui83806_2289.

    Phylogenomic databases

    eggNOGi COG0260.
    HOGENOMi HOG000243129.
    KOi K01255.
    OMAi DSQFADM.
    OrthoDBi EOG6FV8B3.

    Enzyme and pathway databases

    BioCyci BSUI470137:GJIC-710-MONOMER.

    Family and domain databases

    HAMAPi MF_00181. Cytosol_peptidase_M17.
    InterProi IPR011356. Leucine_aapep/pepB.
    IPR000819. Peptidase_M17_C.
    IPR023042. Peptidase_M17_leu_NH2_pept.
    IPR008283. Peptidase_M17_N.
    [Graphical view ]
    Pfami PF00883. Peptidase_M17. 1 hit.
    PF02789. Peptidase_M17_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00481. LAMNOPPTDASE.
    PROSITEi PS00631. CYTOSOL_AP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC 23445 / NCTC 10510Imported.

    Entry informationi

    Entry nameiB0CL13_BRUSI
    AccessioniPrimary (citable) accession number: B0CL13
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3