ID   BETA_BRUSI              Reviewed;         549 AA.
AC   B0CKN4;
DT   20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT   26-FEB-2008, sequence version 1.
DT   16-JUN-2009, entry version 12.
DE   RecName: Full=Choline dehydrogenase;
DE            Short=CHD;
DE            Short=CDH;
DE            EC=1.1.99.1;
GN   Name=betA; OrderedLocusNames=BSUIS_A0581;
OS   Brucella suis (strain ATCC 23445 / NCTC 10510).
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Brucellaceae; Brucella.
OX   NCBI_TaxID=470137;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J.,
RA   Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S.,
RA   Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K.,
RA   Shallom J.M., Shallom S., Shukla M., Snyder E.E., Sobral B.W.,
RA   Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C.,
RA   Munk C., Brettin T.S.;
RT   "Brucella suis ATCC 23445 whole genome shotgun sequencing project.";
RL   Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Can catalyze the oxidation of choline to betaine
CC       aldehyde and betaine aldehyde to glycine betaine (By similarity).
CC   -!- CATALYTIC ACTIVITY: Choline + acceptor = betaine aldehyde +
CC       reduced acceptor.
CC   -!- COFACTOR: FAD (By similarity).
CC   -!- PATHWAY: Amine and polyamine biosynthesis; betaine biosynthesis
CC       via choline pathway; betaine aldehyde from choline (cytochrome c
CC       reductase route): step 1/1.
CC   -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
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DR   EMBL; CP000911; ABY37664.1; -; Genomic_DNA.
DR   RefSeq; YP_001627234.1; -.
DR   GeneID; 5839294; -.
DR   GenomeReviews; CP000911_GR; BSUIS_A0581.
DR   KEGG; bmt:BSUIS_A0581; -.
DR   OMA; B0CKN4; PNLQYHF.
DR   GO; GO:0008812; F:choline dehydrogenase activity; IEA:HAMAP.
DR   GO; GO:0050660; F:FAD binding; IEA:InterPro.
DR   GO; GO:0006066; P:cellular alcohol metabolic process; IEA:InterPro.
DR   GO; GO:0019285; P:glycine betaine biosynthetic process from c...; IEA:HAMAP.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   HAMAP; MF_00750; -; 1.
DR   InterPro; IPR011533; Choline_dehydrogenase.
DR   InterPro; IPR012132; GMC_OxRdtase.
DR   InterPro; IPR000172; GMC_OxRdtase_N.
DR   InterPro; IPR007867; GMC_OxRtase_C.
DR   Pfam; PF05199; GMC_oxred_C; 1.
DR   Pfam; PF00732; GMC_oxred_N; 1.
DR   PIRSF; PIRSF000137; Alcohol_oxidase; 1.
DR   TIGRFAMs; TIGR01810; betA; 1.
DR   PROSITE; PS00623; GMC_OXRED_1; 1.
DR   PROSITE; PS00624; GMC_OXRED_2; 1.
PE   3: Inferred from homology;
KW   Complete proteome; FAD; Flavoprotein; Oxidoreductase.
FT   CHAIN         1    549       Choline dehydrogenase.
FT                                /FTId=PRO_1000083493.
FT   NP_BIND       4     33       FAD (Probable).
FT   ACT_SITE    465    465       By similarity.
SQ   SEQUENCE   549 AA;  60623 MW;  BBAF18D5428B5372 CRC64;
     MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS FPMNMETYDW
     GFSSEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAC DFDHWSQSGA RGWAYADVLP
     YFKRMENSQG GQEGWRGTNG PLYVQRGKRD NPLFHAFVEA GHQAGFEVTD DYNGEKQEGF
     GPMEQTIHNG RRWSAANAYL KPALKRPNVK LVKGFARKIV LEGKRAVGVE IEAGRTFSTI
     RARREVIIAA SSINSPKLLM LSGIGPAAHL KEHGIDLVAD RPGVGQNLQD HLEVYIQQEC
     TQPITLYSKL NLFSKARIGV EWLLFKTGDG ATNHFESAAF VRSKAGVEYP DIQYHFLPVA
     IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP VIKFNYMSHE DDWADFRHCV
     RLTREIFGQA AFDPYRGAEI QPGAHVQTDD EIDNFIREHV ESAFHPCGTC KMGAVDDPMA
     VVDPECRVIG VEGLRVADSS IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSNQEPWI
     NPRWQVSDR
//