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Protein

Oxygen-dependent choline dehydrogenase

Gene

betA

Organism
Brucella suis (strain ATCC 23445 / NCTC 10510)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine at the same rate.UniRule annotation

Catalytic activityi

Choline + acceptor = betaine aldehyde + reduced acceptor.UniRule annotation
Betaine aldehyde + NAD+ + H2O = betaine + NADH.UniRule annotation

Cofactori

FADUniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei465 – 4651UniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi4 – 3330FADUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. betaine-aldehyde dehydrogenase activity Source: UniProtKB-EC
  2. choline dehydrogenase activity Source: UniProtKB-HAMAP
  3. flavin adenine dinucleotide binding Source: InterPro

GO - Biological processi

  1. glycine betaine biosynthetic process from choline Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

FAD, Flavoprotein, NAD

Enzyme and pathway databases

BioCyciBSUI470137:GJIC-576-MONOMER.
UniPathwayiUPA00529; UER00385.

Names & Taxonomyi

Protein namesi
Recommended name:
Oxygen-dependent choline dehydrogenaseUniRule annotation (EC:1.1.99.1UniRule annotation)
Short name:
CDHUniRule annotation
Short name:
CHDUniRule annotation
Alternative name(s):
Betaine aldehyde dehydrogenaseUniRule annotation (EC:1.2.1.8UniRule annotation)
Short name:
BADHUniRule annotation
Gene namesi
Name:betAUniRule annotation
Ordered Locus Names:BSUIS_A0581
OrganismiBrucella suis (strain ATCC 23445 / NCTC 10510)
Taxonomic identifieri470137 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000008545: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 549549Oxygen-dependent choline dehydrogenasePRO_1000083493Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi470137.BSUIS_A0581.

Structurei

3D structure databases

ProteinModelPortaliB0CKN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GMC oxidoreductase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiREMHCPR.
OrthoDBiEOG67HJQP.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0CKN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEADFVIIGS GSAGSAMAYR LSEDGRYSVI VIEYGVPDVG PLIQMPAALS
60 70 80 90 100
FPMNMETYDW GFSSEPEPHI GGRSLVTPRG KVLGGSSSIN GMVYVRGHAC
110 120 130 140 150
DFDHWSQSGA RGWAYADVLP YFKRMENSQG GQEGWRGTNG PLYVQRGKRD
160 170 180 190 200
NPLFHAFVEA GHQAGFEVTD DYNGEKQEGF GPMEQTIHNG RRWSAANAYL
210 220 230 240 250
KPALKRPNVK LVKGFARKIV LEGKRAVGVE IEAGRTFSTI RARREVIIAA
260 270 280 290 300
SSINSPKLLM LSGIGPAAHL KEHGIDLVAD RPGVGQNLQD HLEVYIQQEC
310 320 330 340 350
TQPITLYSKL NLFSKARIGV EWLLFKTGDG ATNHFESAAF VRSKAGVEYP
360 370 380 390 400
DIQYHFLPVA IRYDGKAAAQ SHGFQAHVGP MRSKSRGSVT LRSANPREKP
410 420 430 440 450
VIKFNYMSHE DDWADFRHCV RLTREIFGQA AFDPYRGAEI QPGAHVQTDD
460 470 480 490 500
EIDNFIREHV ESAFHPCGTC KMGAVDDPMA VVDPECRVIG VEGLRVADSS
510 520 530 540
IFPRITNGNL NGPSIMVGEK ASDHILGRTP LARSNQEPWI NPRWQVSDR
Length:549
Mass (Da):60,623
Last modified:February 26, 2008 - v1
Checksum:iBBAF18D5428B5372
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000911 Genomic DNA. Translation: ABY37664.1.
RefSeqiYP_001627234.1. NC_010169.1.

Genome annotation databases

EnsemblBacteriaiABY37664; ABY37664; BSUIS_A0581.
GeneIDi5839294.
KEGGibmt:BSUIS_A0581.
PATRICi17868683. VBIBruSui83806_2145.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000911 Genomic DNA. Translation: ABY37664.1.
RefSeqiYP_001627234.1. NC_010169.1.

3D structure databases

ProteinModelPortaliB0CKN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi470137.BSUIS_A0581.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY37664; ABY37664; BSUIS_A0581.
GeneIDi5839294.
KEGGibmt:BSUIS_A0581.
PATRICi17868683. VBIBruSui83806_2145.

Phylogenomic databases

eggNOGiCOG2303.
HOGENOMiHOG000139600.
KOiK00108.
OMAiREMHCPR.
OrthoDBiEOG67HJQP.

Enzyme and pathway databases

UniPathwayiUPA00529; UER00385.
BioCyciBSUI470137:GJIC-576-MONOMER.

Family and domain databases

HAMAPiMF_00750. Choline_dehydrogen.
InterProiIPR011533. BetA.
IPR012132. GMC_OxRdtase.
IPR000172. GMC_OxRdtase_N.
IPR007867. GMC_OxRtase_C.
[Graphical view]
PfamiPF05199. GMC_oxred_C. 1 hit.
PF00732. GMC_oxred_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMsiTIGR01810. betA. 1 hit.
PROSITEiPS00623. GMC_OXRED_1. 1 hit.
PS00624. GMC_OXRED_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23445 / NCTC 10510.

Entry informationi

Entry nameiBETA_BRUSI
AccessioniPrimary (citable) accession number: B0CKN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: January 7, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.