B0CJJ7 (SAHH_BRUSI) Reviewed, UniProtKB/Swiss-Prot
Last modified
January 25, 2012.
Version 33.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: Adenosylhomocysteinase EC=3.3.1.1 Alternative name(s): S-adenosyl-L-homocysteine hydrolase Short name=AdoHcyase | ||||
| Gene names |
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| Organism | Brucella suis (strain ATCC 23445 / NCTC 10510) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 470137 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella |
Protein attributes
| Sequence length | 466 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Function | May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine By similarity. HAMAP MF_00563 |
| Catalytic activity | S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine. HAMAP MF_00563 |
| Cofactor | Binds 1 NAD per subunit By similarity. HAMAP MF_00563 |
| Pathway | Amino-acid biosynthesis; L-homocysteine biosynthesis; L-homocysteine from S-adenosyl-L-homocysteine: step 1/1. HAMAP MF_00563 |
| Subcellular location | Cytoplasm By similarity HAMAP MF_00563. |
| Sequence similarities | Belongs to the adenosylhomocysteinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | One-carbon metabolism |
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Hydrolase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | one-carbon metabolic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | adenosylhomocysteinase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 466 | 466 | Adenosylhomocysteinase HAMAP MF_00563 | PRO_1000082277 | |||||
Regions | |||||||||
| Nucleotide binding | 193 – 195 | 3 | NAD By similarity | ||||||
| Nucleotide binding | 256 – 261 | 6 | NAD By similarity | ||||||
| Nucleotide binding | 335 – 337 | 3 | NAD By similarity | ||||||
Sites | |||||||||
| Binding site | 57 | 1 | Substrate By similarity | ||||||
| Binding site | 132 | 1 | Substrate By similarity | ||||||
| Binding site | 192 | 1 | Substrate By similarity | ||||||
| Binding site | 222 | 1 | Substrate By similarity | ||||||
| Binding site | 226 | 1 | Substrate By similarity | ||||||
| Binding site | 227 | 1 | NAD By similarity | ||||||
| Binding site | 279 | 1 | NAD By similarity | ||||||
| Binding site | 314 | 1 | NAD By similarity | ||||||
| Binding site | 380 | 1 | NAD By similarity | ||||||
Sequences
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References
| [1] | "Brucella suis ATCC 23445 whole genome shotgun sequencing project." Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. Brettin T.S.Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC 23445 / NCTC 10510. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | CP000911 Genomic DNA. Translation: ABY38949.1. |
| RefSeq | YP_001628519.1. NC_010169.1. |
3D structure databases | |
| ProteinModelPortal | B0CJJ7. |
| SMR | B0CJJ7. Positions 5-466. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | B0CJJ7. |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 5837794. |
| GenomeReviews | Gene locus BSUIS_A1939 in contig CP000911_GR. |
| KEGG | bmt:BSUIS_A1939. |
| PATRIC | 17871509. VBIBruSui83806_3532. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG352029. |
| OMA | SAQVWVT. |
| ProtClustDB | PRK05476. |
Enzyme and pathway databases | |
| BioCyc | BSUI470137:BSUIS_A1939-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00563. AdoHcyase. [Tree] |
| InterPro | IPR000043. Adenosylhomocysteinase. IPR015878. Ado_hCys_hydrolase_NAD-bd. IPR020082. S-Ado-L-homoCys_hydrolase_CS. [Graphical view] |
| KO | K01251. |
| PANTHER | PTHR23420. Ad_hcy_hydrolase. 1 hit. |
| Pfam | PF05221. AdoHcyase. 1 hit. PF00670. AdoHcyase_NAD. 1 hit. [Graphical view] |
| PIRSF | PIRSF001109. Ad_hcy_hydrolase. 1 hit. |
| SMART | SM00996. AdoHcyase. 1 hit. SM00997. AdoHcyase_NAD. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00936. AhcY. 1 hit. |
| PROSITE | PS00738. ADOHCYASE_1. 1 hit. PS00739. ADOHCYASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SAHH_BRUSI | ||||||||
| Accession | Primary (citable) accession number: B0CJJ7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with