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B0CJD0 (AROB_BRUSI) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 35. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
3-dehydroquinate synthase
EC=4.2.3.4
Gene names
Name:aroB
Ordered Locus Names:BSUIS_A1869
OrganismBrucella suis (strain ATCC 23445 / NCTC 10510) [Complete proteome] [HAMAP]
Taxonomic identifier470137 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Alphaproteobacteria › Rhizobiales › Brucellaceae › Brucella

Protein attributes

Sequence length378 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

3-deoxy-D-arabino-hept-2-ulosonate 7-phosphate = 3-dehydroquinate + phosphate. HAMAP MF_00110

Cofactor

Divalent metal cations By similarity. HAMAP MF_00110

NAD By similarity. HAMAP MF_00110

Pathway

Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 2/7. HAMAP MF_00110

Subunit structure

Monomer By similarity. HAMAP MF_00110

Subcellular location

Cytoplasm By similarity HAMAP MF_00110.

Sequence similarities

Belongs to the dehydroquinate synthase family.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   Cellular componentCytoplasm
   LigandNAD
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular function3-dehydroquinate synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 3783783-dehydroquinate synthase HAMAP MF_00110
PRO_1000094466

Sequences

Sequence LengthMass (Da)Tools
B0CJD0 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 9B04CA300E5BF408

FASTA37839,853
        10         20         30         40         50         60 
MNAPTTVADS VTVPVSLGDR SYDILIGKGL VERAGEEVAK RLKGVRVAIV TDENVAAVHL 

        70         80         90        100        110        120 
ERLQASFARA GIDSTPVIVA PGEKSKSFAT LETVTNAILA AKLERGDAVV ALGGGVVGDL 

       130        140        150        160        170        180 
SGFVAGIVRR GMNFVQMPTS LLAQVDSSVG GKTGINTAHG KNLVGVFNQP QLVLADTQVL 

       190        200        210        220        230        240 
DTLSPREFRA GYAEIAKYGL IDRPDFFAWL EANWQEVFSG GAARTKAIAE SCRSKAAVVA 

       250        260        270        280        290        300 
RDERETGDRA LLNLGHTFGH ALESATGYDS SRLVHGEGVA IGMALAYRFS ARMNLAGIEA 

       310        320        330        340        350        360 
AERVEAHLKA VGLPVSLAEV PGGLPPAEKL MDYIAQDKKV TRGTLTFILT HGIGQSFIAK 

       370 
DVPPAAVLEF LKERLAIA

« Hide

References

[1]"Brucella suis ATCC 23445 whole genome shotgun sequencing project."
Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. expand/collapse author list , Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C., Munk C., Brettin T.S.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23445 / NCTC 10510.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000911 Genomic DNA. Translation: ABY38882.1.
RefSeqYP_001628452.1. NC_010169.1.

3D structure databases

ProteinModelPortalB0CJD0.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0CJD0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5837479.
GenomeReviewsGene locus BSUIS_A1869 in contig CP000911_GR.
KEGGbmt:BSUIS_A1869.
PATRIC17871361. VBIBruSui83806_3459.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG632303.
OMAMADEHEQ.
ProtClustDBPRK00002.

Enzyme and pathway databases

BioCycBSUI470137:BSUIS_A1869-MONOMER.

Family and domain databases

HAMAPMF_00110. DHQ_synthase.
[Tree]
InterProIPR016037. DHQ_synth_AroB.
[Graphical view]
KOK01735.
PANTHERPTHR21090:SF1. DHQ_synth_AroB. 1 hit.
PIRSFPIRSF001455. DHQ_synth. 1 hit.
TIGRFAMsTIGR01357. AroB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameAROB_BRUSI
AccessionPrimary (citable) accession number: B0CJD0
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 26, 2008
Last modified: January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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