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B0CIT1

- MDH_BRUSI

UniProt

B0CIT1 - MDH_BRUSI

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Protein

Malate dehydrogenase

Gene
mdh, BSUIS_A1767
Organism
Brucella suis (strain ATCC 23445 / NCTC 10510)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate By similarity.UniRule annotation

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei34 – 341NAD By similarity
Binding sitei83 – 831Substrate By similarity
Binding sitei89 – 891Substrate By similarity
Binding sitei96 – 961NAD By similarity
Binding sitei121 – 1211Substrate By similarity
Binding sitei152 – 1521Substrate By similarity
Active sitei176 – 1761Proton acceptor By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156NAD By similarity
Nucleotide bindingi119 – 1213NAD By similarity

GO - Molecular functioni

  1. L-malate dehydrogenase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. cellular carbohydrate metabolic process Source: InterPro
  2. malate metabolic process Source: InterPro
  3. tricarboxylic acid cycle Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Tricarboxylic acid cycle

Keywords - Ligandi

NAD

Enzyme and pathway databases

BioCyciBSUI470137:GJIC-1758-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenase (EC:1.1.1.37)
Gene namesi
Name:mdh
Ordered Locus Names:BSUIS_A1767
OrganismiBrucella suis (strain ATCC 23445 / NCTC 10510)
Taxonomic identifieri470137 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella
ProteomesiUP000008545: Chromosome I

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 320320Malate dehydrogenaseUniRule annotationPRO_1000081355Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi470137.BSUIS_A1767.

Structurei

3D structure databases

ProteinModelPortaliB0CIT1.
SMRiB0CIT1. Positions 3-311.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0039.
HOGENOMiHOG000213794.
KOiK00024.
OMAiYAPSAFV.
OrthoDBiEOG6091FG.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3.
InterProiIPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR11540. PTHR11540. 1 hit.
PfamiPF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

B0CIT1-1 [UniParc]FASTAAdd to Basket

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MARNKIALIG SGMIGGTLAH LAGLKELGDV VLFDIAEGTP QGKGLDIAES    50
SPVDGFDAKF TGANDYVAIE GADVVIVTAG VPRKPGMSRD DLLGINLKVM 100
EQVGAGIKKY APEAFVICIT NPLDAMVWAL QKFSGLPAHK VVGMAGVLDS 150
ARFRYFLSEE FNVSVEDVTA FVLGGHGDSM VPLARYSTVA GIPLPDLVKM 200
GWTSQDKLDK IIQRTRDGGA EIVGLLKTGS AFYAPAASAI QVAESYLKDK 250
KRVLPVAAQL SGQYGVKDMY VGVPTVIGAN GVERIIEIDL DKDEKAQFDK 300
SVASVAGLCE ACIGIAPSLK 320
Length:320
Mass (Da):33,672
Last modified:February 26, 2008 - v1
Checksum:i0C7F5699F650E91B
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000911 Genomic DNA. Translation: ABY38784.1.
RefSeqiYP_001628354.1. NC_010169.1.

Genome annotation databases

EnsemblBacteriaiABY38784; ABY38784; BSUIS_A1767.
GeneIDi5838246.
KEGGibmt:BSUIS_A1767.
PATRICi17871150. VBIBruSui83806_3355.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000911 Genomic DNA. Translation: ABY38784.1 .
RefSeqi YP_001628354.1. NC_010169.1.

3D structure databases

ProteinModelPortali B0CIT1.
SMRi B0CIT1. Positions 3-311.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 470137.BSUIS_A1767.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY38784 ; ABY38784 ; BSUIS_A1767 .
GeneIDi 5838246.
KEGGi bmt:BSUIS_A1767.
PATRICi 17871150. VBIBruSui83806_3355.

Phylogenomic databases

eggNOGi COG0039.
HOGENOMi HOG000213794.
KOi K00024.
OMAi YAPSAFV.
OrthoDBi EOG6091FG.

Enzyme and pathway databases

BioCyci BSUI470137:GJIC-1758-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
3.90.110.10. 1 hit.
HAMAPi MF_00487. Malate_dehydrog_3.
InterProi IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR11540. PTHR11540. 1 hit.
Pfami PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000102. Lac_mal_DH. 1 hit.
PRINTSi PR00086. LLDHDRGNASE.
SUPFAMi SSF56327. SSF56327. 1 hit.
TIGRFAMsi TIGR01763. MalateDH_bact. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC 23445 / NCTC 10510.

Entry informationi

Entry nameiMDH_BRUSI
AccessioniPrimary (citable) accession number: B0CIT1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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