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B0CGZ7 (B0CGZ7_BRUSI) Unreviewed, UniProtKB/TrEMBL

Last modified November 13, 2013. Version 42. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Isocitrate dehydrogenase [NADP] PIRNR PIRNR000108

EC=1.1.1.42 PIRNR PIRNR000108
Gene names
Ordered Locus Names:BSUIS_A1247 EMBL ABY38298.1
OrganismBrucella suis (strain ATCC 23445 / NCTC 10510) [Complete proteome] [HAMAP] EMBL ABY38298.1
Taxonomic identifier470137 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRhizobialesBrucellaceaeBrucella

Protein attributes

Sequence length404 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. PIRNR PIRNR000108

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity. PIRNR PIRNR000108 PIRSR PIRSR000108-3

Sequence similarities

Belongs to the isocitrate and isopropylmalate dehydrogenases family. PIRNR PIRNR000108 RuleBase RU004443

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding75 – 773NADP By similarity PIRSR PIRSR000108-4
Nucleotide binding308 – 3136NADP By similarity PIRSR PIRSR000108-4
Region94 – 1007Substrate binding By similarity PIRSR PIRSR000108-2

Sites

Metal binding2501Magnesium or manganese By similarity
Metal binding2731Magnesium or manganese By similarity
Binding site771Substrate By similarity PIRSR PIRSR000108-2
Binding site821NADP By similarity PIRSR PIRSR000108-4
Binding site1091Substrate By similarity PIRSR PIRSR000108-2
Binding site1321Substrate By similarity PIRSR PIRSR000108-2
Binding site2581NADP By similarity PIRSR PIRSR000108-4
Binding site3261NADP; via amide nitrogen and carbonyl oxygen By similarity PIRSR PIRSR000108-4
Site1391Critical for catalysis By similarity PIRSR PIRSR000108-1
Site2101Critical for catalysis By similarity PIRSR PIRSR000108-1

Sequences

Sequence LengthMass (Da)Tools
B0CGZ7 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 042250CD0A58DC54

FASTA40445,481
        10         20         30         40         50         60 
MAKIKVANPV VELDGDEMTR IIWQFIKDKL IHPYLDIDLK YYDLSVENRD ATNDQVTIDA 

        70         80         90        100        110        120 
ANAIKEYGVG VKCATITPDE ARVEEFKLKK MWKSPNGTIR NILGGVIFRE PIICKNVPRL 

       130        140        150        160        170        180 
VPGWTQPIIV GRHAFGDQYR ATDFKFPGKG TLTIKFVGED GQTIEHEVYQ APSAGVAMAM 

       190        200        210        220        230        240 
YNLDESIREF ARASFNYGLQ RGYPVYLSTK NTILKAYDGR FKDIFQEVFD AEFKSKFEEK 

       250        260        270        280        290        300 
KIWYEHRLID DMVASALKWS GGYVWACKNY DGDVQSDIVA QGFGSLGLMT SVLMTPDGKT 

       310        320        330        340        350        360 
VEAEAAHGTV TRHYRQYQKG EETSTNSIAS IFAWTRGLAH RAKLDNNADL KKFAETLEKV 

       370        380        390        400 
CVDTVESGFM TKDLALLIGP DQPWLSTTGF LDKIDENLQK AMAA 

« Hide

References

[1]"Brucella suis ATCC 23445 whole genome shotgun sequencing project."
Setubal J.C., Bowns C., Boyle S., Crasta O.R., Czar M.J., Dharmanolla C., Gillespie J.J., Kenyon R.W., Lu J., Mane S., Mohapatra S., Nagrani S., Purkayastha A., Rajasimha H.K., Shallom J.M., Shallom S., Shukla M., Snyder E.E. expand/collapse author list , Sobral B.W., Wattam A.R., Will R., Williams K., Yoo H., Bruce D., Detter C., Munk C., Brettin T.S.
Submitted (DEC-2007) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC 23445 / NCTC 10510.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000911 Genomic DNA. Translation: ABY38298.1.
RefSeqYP_001627868.1. NC_010169.1.

3D structure databases

ProteinModelPortalB0CGZ7.
SMRB0CGZ7. Positions 3-403.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING470137.BSUIS_A1247.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY38298; ABY38298; BSUIS_A1247.
GeneID5838496.
KEGGbmt:BSUIS_A1247.
PATRIC17870071. VBIBruSui83806_2831.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0538.
HOGENOMHOG000019858.
KOK00031.
OMAQHQQGKP.
OrthoDBEOG628F3X.
ProtClustDBPRK08299.

Enzyme and pathway databases

BioCycBSUI470137:GJIC-1238-MONOMER.

Family and domain databases

Gene3D3.40.718.10. 1 hit.
InterProIPR019818. IsoCit/isopropylmalate_DH_CS.
IPR004790. Isocitrate_DH_NADP.
IPR024084. IsoPropMal-DH-like_dom.
[Graphical view]
PANTHERPTHR11822. PTHR11822. 1 hit.
PfamPF00180. Iso_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000108. IDH_NADP. 1 hit.
TIGRFAMsTIGR00127. nadp_idh_euk. 1 hit.
PROSITEPS00470. IDH_IMDH. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0CGZ7_BRUSI
AccessionPrimary (citable) accession number: B0CGZ7
Entry history
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 13, 2013
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)