B0CEU2 (TRPC_ACAM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Indole-3-glycerol phosphate synthase
Short name=IGPS
EC=4.1.1.48

Gene names

Name:	trpC
Ordered Locus Names:	AM1_4360

Organism

Acaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]

Taxonomic identifier

329726 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Acaryochloris

Protein attributes

Sequence length	303 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-C-(3-indolyl)-glycerol 3-phosphate + CO2 + H2O. HAMAP MF_00134_B
Pathway	Amino-acid biosynthesis; L-tryptophan biosynthesis; L-tryptophan from chorismate: step 4/5. HAMAP MF_00134_B
Sequence similarities	Belongs to the TrpC family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis Tryptophan biosynthesis
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	tryptophan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	indole-3-glycerol-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 303	303	Indole-3-glycerol phosphate synthase HAMAP MF_00134_B		PRO_1000076413

Sequences

	Sequence		Length	Mass (Da)
	B0CEU2 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 01CCD68D2915729E	FASTA	303	33,343
	10 20 30 40 50 60 MQIRRRPPSV AVNVQELQYQ VKTPENEPRN ILEKIVWFKE TEVEQMRDSV SLLDLRKQVA 70 80 90 100 110 120 NCEPPLSFLD ALKHGKTQPA LIAEVKKASP SKGVLRENFD PVAIAQAYEA AGASCLSVLT 130 140 150 160 170 180 DAEFFQGSFD YLQQIRAAVS LPLLCKEFVI YPYQIYLARS RGADAVLLIA AILSDQDLTY 190 200 210 220 230 240 FLKIIKSLGM TALVEVHTLP ELERVMDIPG IELIGINNRD LETFTVDLEV TCQLLAQQGT 250 260 270 280 290 300 SLQDQDILVV SESGLHTSAD LAQVKQAGAG AVLIGESLVK ETGNASTHSE TEQMQAKISA LFS

References

[1]

"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina." Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W. Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MBIC 11017.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000828 Genomic DNA. Translation: ABW29339.1.
RefSeq	YP_001518656.1. NC_009925.1.
3D structure databases
ProteinModelPortal	B0CEU2.
ModBase	Search...
Protein-protein interaction databases
STRING	B0CEU2.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5683163.
GenomeReviews	Gene locus AM1_4360 in contig CP000828_GR.
KEGG	amr:AM1_4360.
PATRIC	20622810. VBIAcaMar40141_4026.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG540956.
OMA	LEYAVPH.
PhylomeDB	B0CEU2.
ProtClustDB	CLSK2475852.
Enzyme and pathway databases
BioCyc	AMAR329726:AM1_4360-MONOMER.
Family and domain databases
HAMAP	MF_00134_B. IGPS_B. [Tree]
InterPro	IPR013785. Aldolase_TIM. IPR013798. Indole-3-glycerol_P_synth. IPR001468. Indole-3-GlycerolPSynthase_CS. IPR011060. RibuloseP-bd_barrel. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01609.
Pfam	PF00218. IGPS. 1 hit. [Graphical view]
SUPFAM	SSF51366. RibP_bind_barrel. 1 hit.
PROSITE	PS00614. IGPS. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

TRPC_ACAM1

Accession

Primary (citable) accession number: B0CEU2

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 25 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program