Reviewed, UniProtKB/Swiss-Prot B0CEJ4 (AROQ_ACAM1)

Names and origin

Protein names

Recommended name:
3-dehydroquinate dehydratase
Short name=3-dehydroquinase
EC=4.2.1.10

Alternative name(s):
Type II DHQase

Gene names

Name:	aroQ
Ordered Locus Names:	AM1_1943

Organism

Acaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]

Taxonomic identifier

329726 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Acaryochloris

Protein attributes

Sequence length	149 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes a trans-dehydration via an enolate intermediate By similarity. HAMAP MF_00169
Catalytic activity	3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00169
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00169
Subunit structure	Homododecamer By similarity. HAMAP MF_00169
Sequence similarities	Belongs to the type-II 3-dehydroquinase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: HAMAP
Molecular function	3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 149	149	3-dehydroquinate dehydratase HAMAP MF_00169		PRO_1000097584
Regions
	Region	103 – 104	2	Substrate binding By similarity
Sites
	Active site	25	1	Proton acceptor By similarity
	Active site	102	1	Proton donor By similarity
	Binding site	76	1	Substrate By similarity
	Binding site	82	1	Substrate By similarity
	Binding site	89	1	Substrate By similarity
	Binding site	113	1	Substrate By similarity
	Site	20	1	Transition state stabilizer HAMAP MF_00169

Sequences

	Sequence		Length	Mass (Da)
	B0CEJ4-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: B207C1327A92D44B	FASTA	149	16,261
	10 20 30 40 50 60 MSRPSILVLH GPNLNLLGQR EPGIYGSVTL EKINQQLLSL AESLKCNIEF YQSNHEGNLV 70 80 90 100 110 120 DSIQEALGCH NGILINAAAY THTSVAIRDA LAAVAIPAVE VHLSNIYRRE DFRHHSFIAP 130 140 IVIGQISGFG AQSYSLGLQA LIHHLQTQT

References

[1]

"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina." Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W. Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000828 Genomic DNA. Translation: ABW26960.1.
RefSeq	YP_001516274.1.
3D structure databases
SMR	B0CEJ4. Positions 4-143.
ModBase	Search...
Genome annotation databases
GeneID	5680758.
GenomeReviews	Gene locus AM1_1943 in contig CP000828_GR.
KEGG	amr:AM1_1943.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG284657.
OMA	EPFRHRS.
ProtClustDB	PRK05395.
Family and domain databases
HAMAP	MF_00169. AroQ. [Tree]
InterPro	IPR001874. DHquinase_II. IPR018509. DHquinase_II_CS. [Graphical view]
Gene3D	G3DSA:3.40.50.9100. DHquinase_II. 1 hit.
PANTHER	PTHR21272. DHquinase_II. 1 hit.
Pfam	PF01220. DHquinase_II. 1 hit. [Graphical view]
PIRSF	PIRSF001399. DHquinase_II. 1 hit.
ProDom	PD004527. DHquinase_II. 1 hit. [Graphical view] [Entries sharing at least one domain]
SUPFAM	SSF52304. DHquinase_II. 1 hit.
TIGRFAMs	TIGR01088. aroQ. 1 hit.
PROSITE	PS01029. DEHYDROQUINASE_II. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROQ_ACAM1

Accession

Primary (citable) accession number: B0CEJ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	March 2, 2010
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)