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B0CD73 (B0CD73_ACAM1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 32. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Coproporphyrinogen-III oxidase, aerobic HAMAP MF_00333
Short name=Coprogen oxidase HAMAP MF_00333
Short name=Coproporphyrinogenase HAMAP MF_00333
EC=1.3.3.3 HAMAP MF_00333
Gene names
Name:hemF HAMAP MF_00333 EMBL ABW25664.1
Ordered Locus Names:AM1_0615
OrganismAcaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]
Taxonomic identifier329726 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Acaryochloris

Protein attributes

Sequence length341 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Key enzyme in heme biosynthesis. Catalyzes the oxidative decarboxylation of propionic acid side chains of rings A and B of coproporphyrinogen III By similarity. HAMAP MF_00333 SAAS SAAS018375

Catalytic activity

Coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O. HAMAP MF_00333 SAAS SAAS018375

Pathway

Porphyrin metabolism; protoporphyrin-IX biosynthesis; protoporphyrinogen-IX from coproporphyrinogen-III (O2 route): step 1/1. HAMAP MF_00333 SAAS SAAS018375

Subunit structure

Homodimer By similarity. HAMAP MF_00333 SAAS SAAS018375

Subcellular location

Cytoplasm By similarity HAMAP MF_00333.

Sequence similarities

Belongs to the aerobic coproporphyrinogen-III oxidase family. HAMAP MF_00333

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region66 – 7510Important for dimerization By similarity HAMAP MF_00333
Region126 – 1283Substrate binding By similarity HAMAP MF_00333
Region279 – 31436Important for dimerization By similarity HAMAP MF_00333
Region297 – 3026Substrate binding By similarity HAMAP MF_00333

Sites

Active site1241Proton donor By similarity HAMAP MF_00333
Binding site1101Substrate By similarity HAMAP MF_00333
Site1881Important for dimerization By similarity HAMAP MF_00333

Sequences

Sequence LengthMass (Da)Tools
B0CD73 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: D807E508B1F4AAB9

FASTA34138,935
        10         20         30         40         50         60 
MTASPSTPAA VTNAPPPPSD SKEQVGKFLR GLQDSICDKL QTLDGKSTFQ EDSWDRPEGG 

        70         80         90        100        110        120 
GGRSRVLREG GLLEQGGVNY SEVWGDHLPP SILKQRPEAA GHRFYATGTS MVLHPRSPYV 

       130        140        150        160        170        180 
PTVHLNYRYF EAGPVWWFGG GIDLTPYYPF KEDVVHFHQT MKAACDRHHP EYYSTFKPWC 

       190        200        210        220        230        240 
DEYFYLKHRQ EMRGVGGIFF DYQDGIGALY RGPHAEGIAA HHSDQLGSLP QRSWDEIFAF 

       250        260        270        280        290        300 
AQDCGNAFLP AYVPIVERRR DTEYGDRERN FQLYRRGRYV EFNLVYDRGT IFGLQTNGRT 

       310        320        330        340 
ESILMSLPPL VRWEYAYSPE PDTPEAELYE TFLKPQDWAS A

« Hide

References

[1]"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina."
Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. expand/collapse author list , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W.
Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000828 Genomic DNA. Translation: ABW25664.1.
RefSeqYP_001514978.1. NC_009925.1.

3D structure databases

ProteinModelPortalB0CD73.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0CD73.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5679443.
GenomeReviewsGene locus AM1_0615 in contig CP000828_GR.
KEGGamr:AM1_0615.
PATRIC20615756. VBIAcaMar40141_0529.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG631180.
OMAVKAYLLD.
PhylomeDBB0CD73.
ProtClustDBPRK05330.

Family and domain databases

HAMAPMF_00333. Coprogen_oxidas.
[Tree]
InterProIPR001260. Coprogen_oxidase_aer.
IPR018375. Coprogen_oxidase_CS.
[Graphical view]
Gene3DG3DSA:3.40.1500.10. Coprogen_oxidas. 1 hit.
KOK00228.
PANTHERPTHR10755. Coprogen_oxidas. 1 hit.
PfamPF01218. Coprogen_oxidas. 2 hits.
[Graphical view]
PIRSFPIRSF000166. Coproporphyri_ox. 1 hit.
PRINTSPR00073. COPRGNOXDASE.
SUPFAMSSF102886. Coprogen_oxidas. 1 hit.
PROSITEPS01021. COPROGEN_OXIDASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0CD73_ACAM1
AccessionPrimary (citable) accession number: B0CD73
Entry history
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: December 14, 2011
This is version 32 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info