Reviewed, UniProtKB/Swiss-Prot B0CD68 (ARGC_ACAM1)

Names and origin

Protein names

Recommended name:
    N-acetyl-gamma-glutamyl-phosphate reductase
      Short name=AGPR
    EC=1.2.1.38
Alternative name(s):
    N-acetyl-glutamate semialdehyde dehydrogenase
      Short name=NAGSA dehydrogenase

Gene names

Name:	argC
Ordered Locus Names:	AM1_0609

Organism

Acaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]

Taxonomic identifier

329726 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Acaryochloris

Protein attributes

Sequence length	352 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH. HAMAP MF_00150
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; N(2)-acetyl-L-ornithine from L-glutamate: step 3/4. HAMAP MF_00150
Subcellular location	Cytoplasm By similarity HAMAP MF_00150.
Sequence similarities	Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Ligand	NADP
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	N-acetyl-gamma-glutamyl-phosphate reductase activity Inferred from electronic annotation. Source: HAMAP NAD or NADH binding Inferred from electronic annotation. Source: InterPro protein dimerization activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 352	352	N-acetyl-gamma-glutamyl-phosphate reductase HAMAP MF_00150		PRO_1000076725
Sites
	Active site	155	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0CD68-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 179DFEF39CA1DE3E	FASTA	352	38,109
	10 20 30 40 50 60 MGSQEDIPVG IIGASGYGGV QLTRLLLEHP HVHLAYLGGD SSAGRPFADL YPHLGFKQDL 70 80 90 100 110 120 KVEAIDLDKV VERTQVVFLA LPNGLAAEMA PTLVECGCKV LDLSADYRFT NLDTYEDWYG 130 140 150 160 170 180 TKRQDRDLAS TAVYGLPELY RQGISTASLV GCPGCFPTAS LLALAPLLKQ GLIDPNSAII 190 200 210 220 230 240 DAKTGTSGGG RQAKTHLLLA EANGSIGPYG VAHHRHTPEI EQVSSDLAGR EVVVQFTPHL 250 260 270 280 290 300 APMTRGILAT VYATMRDPGL VREDLITIFS AFYRNSPWVK VLPGSTYPFT KWAYGTNLCY 310 320 330 340 350 LGIEVDQRTG RVIVISAIDN LMKGQAGQAV QCLNLMMGWP ETMGLPELTF YP

References

[1]

"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina." Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W. Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000828 Genomic DNA. Translation: ABW25659.1.
RefSeq	YP_001514973.1.
3D structure databases
SMR	B0CD68. Positions 7-352.
ModBase	Search...
Genome annotation databases
GeneID	5679437.
GenomeReviews	Gene locus AM1_0609 in contig CP000828_GR.
KEGG	amr:AM1_0609.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG294213.
OMA	TAEDCTT.
Family and domain databases
HAMAP	MF_00150. ArgC_type1. [Tree]
InterPro	IPR000706. AGPR_act_site. IPR016040. NAD(P)-bd_dom. IPR000534. Semialdehyde_DH_NAD-bd. IPR012280. Semialdhyde_DH_dimer_dom. [Graphical view]
Pfam	PF01118. Semialdhyde_dh. 1 hit. PF02774. Semialdhyde_dhC. 1 hit. [Graphical view]
SMART	SM00859. Semialdhyde_dh. 1 hit. [Graphical view]
TIGRFAMs	TIGR01850. argC. 1 hit.
PROSITE	PS01224. ARGC. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARGC_ACAM1

Accession

Primary (citable) accession number: B0CD68

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 26, 2008
Last modified:	February 9, 2010
This is version 19 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)