Reviewed, UniProtKB/Swiss-Prot B0CCD6 (MURC_ACAM1)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylmuramate--L-alanine ligase
    EC=6.3.2.8
Alternative name(s):
    UDP-N-acetylmuramoyl-L-alanine synthetase

Gene names

Name:	murC
Ordered Locus Names:	AM1_1800

Organism

Acaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]

Taxonomic identifier

329726 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Acaryochloris

Protein attributes

Sequence length	487 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation By similarity.
Catalytic activity	ATP + UDP-N-acetylmuramate + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine. HAMAP MF_00046
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00046
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the murCDEF family.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP UDP-N-acetylmuramate-L-alanine ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 487	487	UDP-N-acetylmuramate--L-alanine ligase HAMAP MF_00046		PRO_1000074727
Regions
	Nucleotide binding	124 – 130	7	ATP Potential

Sequences

	Sequence		Length	Mass (Da)
	B0CCD6-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 2DE4A732E4EE909A	FASTA	487	52,176
	10 20 30 40 50 60 MQSAVDLGGR PIHFIGVGGI GMSALAHILL KRQLPISGSD ARANHITQKL ESQGAQIFSR 70 80 90 100 110 120 QEATNIKQLC QGSSAPPQVI CSTAIHEDNP EYQAAVQAGC PIFHRSDVLA ALMQEFPQSI 130 140 150 160 170 180 AIAGTHGKTT TSSLVGYLLL QASLDPTIIV GGEVAAWGGN ARTGESPYLV AEADESDGSL 190 200 210 220 230 240 VKFFPHIGVI TNIELDHPDH YTSLDQVVSI FQEFVDHCHT LIVSVDCPTI ADRFLALATD 250 260 270 280 290 300 QSMITYSLSS KVSADYTVQN IDYSGQGTIV EVLERGESLG QLELPLLGEH NLSNALAAVA 310 320 330 340 350 360 VGRYVGLEFP AIAKALRTFS GAKRRFEIYG EAQGICLIDD YAHHPSEIQV TLASAKLQAQ 370 380 390 400 410 420 AAAATYSQSR VVAVFQPHRY SRAATFFQEF SQSFQDADLV VVTDIYSAGE ANPGTINGKK 430 440 450 460 470 480 LADAIAANHS VVTFQPTLTN VIDFLQGHLQ SGDVVLFLGA GDLNRIIPDL LTHFQVSSKP SPEVVLK

References

[1]

"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina." Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W. Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000828 Genomic DNA. Translation: ABW26821.1.
RefSeq	YP_001516135.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5680616.
GenomeReviews	Gene locus AM1_1800 in contig CP000828_GR.
KEGG	amr:AM1_1800.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	EWMVVEA.
Family and domain databases
HAMAP	MF_00046. [Tree]
InterPro	IPR004101. Mur_ligase_C. IPR013221. Mur_ligase_cen. IPR000713. Mur_ligase_N. IPR016040. NAD(P)-bd_dom. IPR005758. UDP-N-AcMur_Ala_ligase. [Graphical view]
Gene3D	G3DSA:3.90.190.20. Mur_ligase_C. 1 hit. G3DSA:3.40.1190.10. Mur_ligase_cen. 1 hit. G3DSA:3.40.50.720. NAD(P)-bd. 1 hit.
Pfam	PF01225. Mur_ligase. 1 hit. PF02875. Mur_ligase_C. 1 hit. PF08245. Mur_ligase_M. 1 hit. [Graphical view]
TIGRFAMs	TIGR01082. murC. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURC_ACAM1

Accession

Primary (citable) accession number: B0CCD6

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)