Skip Header

Contribute Send feedback
Read comments (?) or add your own

B0CBB6 (B0CBB6_ACAM1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Histidinol dehydrogenase PIRNR PIRNR000099
Short name=HDH PIRNR PIRNR000099
EC=1.1.1.23 PIRNR PIRNR000099
Gene names
Name:hisD EMBL ABW27901.1
Ordered Locus Names:AM1_2902
OrganismAcaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]
Taxonomic identifier329726 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Acaryochloris

Protein attributes

Sequence length435 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity. PIRNR PIRNR000099 SAAS SAAS001692

Catalytic activity

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH. PIRNR PIRNR000099 SAAS SAAS001692

Cofactor

Binds 1 zinc ion per subunit By similarity. SAAS SAAS001692

Pathway

Amino-acid biosynthesis; L-histidine biosynthesis; L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate: step 9/9. PIRNR PIRNR000099 SAAS SAAS001692

Sequence similarities

Belongs to the histidinol dehydrogenase family. PIRNR PIRNR000099 RuleBase RU004175

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site3301Proton acceptor By similarity PIRSR PIRSR000099-1
Active site3311Proton acceptor By similarity PIRSR PIRSR000099-1
Binding site1301NAD By similarity PIRSR PIRSR000099-2
Binding site1921NAD By similarity PIRSR PIRSR000099-2
Binding site2151NAD By similarity PIRSR PIRSR000099-2

Sequences

Sequence LengthMass (Da)Tools
B0CBB6 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 4A81FFA2B5AB910B

FASTA43546,726
        10         20         30         40         50         60 
MVRILRLSEM TSEELASIKR RAELDIEQAL AVAKEVIDEI RADGDQGVIK YVRKFDFPGA 

        70         80         90        100        110        120 
TAENLKVTEA EFAAAREQVE PEIKAAIEQA YRNIKEVHER QMPEEVQLAE IDGGVFAGEK 

       130        140        150        160        170        180 
VTPIASAGLY VPRGKGSFPS VMLMLSVPAV VAGVEKVVVC TPPDKNGTVE PASLVAAELA 

       190        200        210        220        230        240 
GVKDIYKLGG IQAIAGMAIG TETVPKVDKI TGPCNVYGSA AKRLLYGTVD VGLPAGPSES 

       250        260        270        280        290        300 
IILTDETTDP RIAALDLLVE AEHGPDSAGL LVTHSEDLAK AASKHADDYM EKLPDWRKNF 

       310        320        330        340        350        360 
CQTGLSSYGG IILTSSLEES IDFLNEYAPE HLEVLVQDPL SVLGKIKNAG EILLGPYTPI 

       370        380        390        400        410        420 
PTANYCIGVN AILPTGGFAR SYSAVSVYDF LKRTGIGYLT QEGFARLGHT AQTLAEHEDF 

       430 
PAHAMAIRER KNLLP

« Hide

References

[1]"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina."
Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. expand/collapse author list , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W.
Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000828 Genomic DNA. Translation: ABW27901.1.
RefSeqYP_001517217.1. NC_009925.1.

3D structure databases

ProteinModelPortalB0CBB6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0CBB6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5681710.
GenomeReviewsGene locus AM1_2902 in contig CP000828_GR.
KEGGamr:AM1_2902.
PATRIC20620084. VBIAcaMar40141_2672.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG329596.
OMAKIVGPGS.
PhylomeDBB0CBB6.
ProtClustDBPRK00877.

Family and domain databases

HAMAPMF_01024. HisD.
[Tree]
InterProIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
KOK00013.
PANTHERPTHR21256:SF2. Hstdl_DH_prok. 1 hit.
PfamPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFPIRSF000099. Histidinol_dh. 1 hit.
PRINTSPR00083. HOLDHDRGNASE.
SUPFAMSSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMsTIGR00069. HisD. 1 hit.
PROSITEPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameB0CBB6_ACAM1
AccessionPrimary (citable) accession number: B0CBB6
Entry history
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: December 14, 2011
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info