B0CB70 (GLPK_ACAM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glycerol kinase
EC=2.7.1.30

Alternative name(s):
ATP:glycerol 3-phosphotransferase
Glycerokinase
Short name=GK

Gene names

Name:	glpK
Ordered Locus Names:	AM1_1688

Organism

Acaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]

Taxonomic identifier

329726 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Acaryochloris

Protein attributes

Sequence length	502 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Key enzyme in the regulation of glycerol uptake and metabolism By similarity. HAMAP MF_00186
Catalytic activity	ATP + glycerol = ADP + sn-glycerol 3-phosphate. HAMAP MF_00186
Pathway	Polyol metabolism; glycerol degradation via glycerol kinase pathway; sn-glycerol 3-phosphate from glycerol: step 1/1. HAMAP MF_00186
Sequence similarities	Belongs to the FGGY kinase family.

Ontologies

Keywords
Biological process	Glycerol metabolism
Ligand	ATP-binding Nucleotide-binding
Molecular function	Kinase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycerol-3-phosphate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW glycerol kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 502	502	Glycerol kinase HAMAP MF_00186		PRO_1000124175
Regions
	Nucleotide binding	415 – 419	5	ATP By similarity
Sites
	Binding site	14	1	Substrate By similarity
	Binding site	18	1	ATP By similarity
	Binding site	84	1	Substrate By similarity
	Binding site	136	1	Substrate By similarity
	Binding site	245	1	Substrate By similarity
	Binding site	267	1	ATP By similarity
	Binding site	314	1	ATP; via carbonyl oxygen By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0CB70 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: B0E9C08737409E1D	FASTA	502	54,636
	10 20 30 40 50 60 MTSATYIMAL DLGTTGNRAI LFDQDGQIVD QAYKELPQYY PQPGWVEHDA LEIWRDTRWA 70 80 90 100 110 120 METVVTQAHI DPAQIAAIGL TVQRETCLLW DKTTGQPLHK AIVWQDRRTA AYCNQLAEQG 130 140 150 160 170 180 HTQDIYDRTG LVLDAYFSGS KLAWLLTEVK RQNPNLNLDN VIAGTIDTWA LWNLTGGKVH 190 200 210 220 230 240 ATDHSNASRT LLLNLSQGTW DDHLLDLFGI PKSFMPAIQP SLGIFGKTDT KFLGQEIPIA 250 260 270 280 290 300 AIFGDQQAAL FAHGCDRPGA LKCTYGTGSF LVAHTGSNIA RSKNRLLSTV AWTQTDKGQT 310 320 330 340 350 360 QTGYAIEGSM FTSGACIQWL RDGLKLIANA AETEGLAQAV EDNGGVYFVP ALSGLGAPHW 370 380 390 400 410 420 DMSARGAFLG ITRGAQREHM VRAVLEAIAF QTKEVVDAVN QDCGSPIQQL KVDGGACQNN 430 440 450 460 470 480 FLMQYQADVL GIPVERPAVL DATAQGAAFG AGLAIGVWKD YAGLVAARKI DQVFKPGANA 490 500 QTAQANFKTW QKAVERAKNW AD

References

[1]

"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina." Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W. Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MBIC 11017.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000828 Genomic DNA. Translation: ABW26709.1.
RefSeq	YP_001516023.1. NC_009925.1.
3D structure databases
ProteinModelPortal	B0CB70.
ModBase	Search...
Protein-protein interaction databases
STRING	B0CB70.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5680504.
GenomeReviews	Gene locus AM1_1688 in contig CP000828_GR.
KEGG	amr:AM1_1688.
PATRIC	20617756. VBIAcaMar40141_1516.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG511469.
OMA	ATYFSGT.
PhylomeDB	B0CB70.
ProtClustDB	CLSK893231.
Enzyme and pathway databases
BioCyc	AMAR329726:AM1_1688-MONOMER.
Family and domain databases
HAMAP	MF_00186. Glycerol_kin. [Tree]
InterPro	IPR000577. Carb_kinase_FGGY. IPR018485. Carb_kinase_FGGY_C. IPR018483. Carb_kinase_FGGY_CS. IPR018484. Carb_kinase_FGGY_N. IPR005999. Glycerol_kin. [Graphical view]
KO	K00864.
PANTHER	PTHR10196. FGGY_kin. 1 hit. PTHR10196:SF9. Glycerol_kin. 1 hit.
Pfam	PF02782. FGGY_C. 1 hit. PF00370. FGGY_N. 1 hit. [Graphical view]
TIGRFAMs	TIGR01311. Glycerol_kin. 1 hit.
PROSITE	PS00933. FGGY_KINASES_1. 1 hit. PS00445. FGGY_KINASES_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLPK_ACAM1

Accession

Primary (citable) accession number: B0CB70

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 28, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program