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B0CAX6 (B0CAX6_ACAM1) Unreviewed, UniProtKB/TrEMBL

Last modified December 14, 2011. Version 24. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Orotate phosphoribosyltransferase HAMAP MF_01208
Short name=OPRT HAMAP MF_01208
Short name=OPRTase HAMAP MF_01208
EC=2.4.2.10 HAMAP MF_01208
Gene names
Name:pyrE HAMAP MF_01208 EMBL ABW25466.1
Ordered Locus Names:AM1_0409
OrganismAcaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]
Taxonomic identifier329726 [NCBI]
Taxonomic lineageBacteria › Cyanobacteria › Chroococcales › Acaryochloris

Protein attributes

Sequence length173 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP) By similarity. HAMAP MF_01208 SAAS SAAS004467

Catalytic activity

Orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_01208 SAAS SAAS023031

Cofactor

Magnesium By similarity. HAMAP MF_01208

Pathway

Pyrimidine metabolism; UMP biosynthesis via de novo pathway; UMP from orotate: step 1/2. HAMAP MF_01208 SAAS SAAS023031

Subunit structure

Homodimer By similarity. HAMAP MF_01208 SAAS SAAS004467

Sequence similarities

Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily. HAMAP MF_01208

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Region115 – 12395-phosphoribose 1-diphosphate binding By similarity HAMAP MF_01208

Sites

Binding site2415-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site8915-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site9015-phosphoribose 1-diphosphate By similarity HAMAP MF_01208
Binding site9315-phosphoribose 1-diphosphate; shared with dimeric partner By similarity HAMAP MF_01208
Binding site1191Orotate By similarity HAMAP MF_01208

Sequences

Sequence LengthMass (Da)Tools
B0CAX6 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 9E0FBE8511EDE12B

FASTA17318,669
        10         20         30         40         50         60 
MMNKADLAKA IYETSHITGE FLLRSGQMSH EYFDKYLFEA NPTLLKAIAE HLAAMIPTPV 

        70         80         90        100        110        120 
DALAGLEMGG IPIVAMLSQI SGYPSLFVRK KAKPYGTCKL AEGGEIEGKR LVIIEDVVTS 

       130        140        150        160        170 
GGQIKLSAQD LRSLGATVTD VMCVIDREAG GQANLNAEGL TLHPLFTMTE LKQ

« Hide

References

[1]"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina."
Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. expand/collapse author list , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W.
Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000828 Genomic DNA. Translation: ABW25466.1.
RefSeqYP_001514780.1. NC_009925.1.

3D structure databases

ProteinModelPortalB0CAX6.
ModBaseSearch...

Protein-protein interaction databases

STRINGB0CAX6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5679240.
GenomeReviewsGene locus AM1_0409 in contig CP000828_GR.
KEGGamr:AM1_0409.
PATRIC20615366. VBIAcaMar40141_0336.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG404341.
OMAEMGGIPI.
PhylomeDBB0CAX6.

Family and domain databases

HAMAPMF_01208. PyrE.
[Tree]
InterProIPR004467. Or_phspho_trans_clade-1.
IPR023031. Orotate_PribosylTferase.
IPR000836. PRibTrfase.
[Graphical view]
KOK00762.
PfamPF00156. Pribosyltran. 1 hit.
[Graphical view]
TIGRFAMsTIGR00336. PyrE. 1 hit.
ProtoNetSearch...

Entry information

Entry nameB0CAX6_ACAM1
AccessionPrimary (citable) accession number: B0CAX6
Entry history
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: December 14, 2011
This is version 24 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info