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Protein

UDP-N-acetylmuramoylalanine--D-glutamate ligase

Gene

murD

Organism
Acaryochloris marina (strain MBIC 11017)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).UniRule annotation

Catalytic activityi

ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-D-glutamate.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi118 – 1247ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMAR329726:GCZJ-1515-MONOMER.
UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
UDP-N-acetylmuramoylalanine--D-glutamate ligaseUniRule annotation (EC:6.3.2.9UniRule annotation)
Alternative name(s):
D-glutamic acid-adding enzymeUniRule annotation
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetaseUniRule annotation
Gene namesi
Name:murDUniRule annotation
Ordered Locus Names:AM1_1525
OrganismiAcaryochloris marina (strain MBIC 11017)
Taxonomic identifieri329726 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesAcaryochloris
Proteomesi
  • UP000000268 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 461461UDP-N-acetylmuramoylalanine--D-glutamate ligasePRO_1000082675Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi329726.AM1_1525.

Structurei

3D structure databases

ProteinModelPortaliB0C915.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the MurCDEF family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DMZ. Bacteria.
COG0771. LUCA.
HOGENOMiHOG000049428.
KOiK01925.
OMAiPGIPYTN.
OrthoDBiPOG091H002Z.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00639. MurD. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PfamiPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01087. murD. 1 hit.

Sequencei

Sequence statusi: Complete.

B0C915-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPAVHIIGLG RSGIAAARLL RREGWQVSVG DAGHSEGLVA TQKTLAAEGI
60 70 80 90 100
PVHLNLKFSL SALAELSLDR PDRIVVSPGV PWQLPALEEA RSQGIETFGE
110 120 130 140 150
LELAWRSLKQ YPWVGITGTN GKTTTTAIVE AIFKAAGLRA PACGNIGYSA
160 170 180 190 200
CELALAGDPL DWVIAEVSSY QIESSPTLAP TIGVWTTFSP DHLERHGTVE
210 220 230 240 250
CYREIKALLL NQSKQKILNG DDQGLIKGLP WRWADAYWTS SHGPSLPDAC
260 270 280 290 300
NGQRCPVPNI FIEEGWVKVE GEPIVQVSSM RMLGVHNQQN LLLAVAVAHL
310 320 330 340 350
AGIGKDAIAT AVSTFPGVAH RLEHICTWQG VDFINDSKAT NYEAAQTGLA
360 370 380 390 400
AVNSPAILIA GGEAKVGDDQ AWLQTIQAQA AKVLLIGSAA GAFSQRLKAI
410 420 430 440 450
GYDDYEIVDT MNKAVTRAAE LAPSLQAKSV LLSPACASFD QYQNFERRGD
460
HFRQLCQDLS Q
Length:461
Mass (Da):49,514
Last modified:February 26, 2008 - v1
Checksum:iA7F9BD8FA96EBF8E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000828 Genomic DNA. Translation: ABW26550.1.
RefSeqiWP_012162075.1. NC_009925.1.

Genome annotation databases

EnsemblBacteriaiABW26550; ABW26550; AM1_1525.
KEGGiamr:AM1_1525.
PATRICi20617448. VBIAcaMar40141_1362.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000828 Genomic DNA. Translation: ABW26550.1.
RefSeqiWP_012162075.1. NC_009925.1.

3D structure databases

ProteinModelPortaliB0C915.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi329726.AM1_1525.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW26550; ABW26550; AM1_1525.
KEGGiamr:AM1_1525.
PATRICi20617448. VBIAcaMar40141_1362.

Phylogenomic databases

eggNOGiENOG4105DMZ. Bacteria.
COG0771. LUCA.
HOGENOMiHOG000049428.
KOiK01925.
OMAiPGIPYTN.
OrthoDBiPOG091H002Z.

Enzyme and pathway databases

UniPathwayiUPA00219.
BioCyciAMAR329726:GCZJ-1515-MONOMER.

Family and domain databases

Gene3Di3.40.1190.10. 1 hit.
3.40.50.720. 1 hit.
3.90.190.20. 1 hit.
HAMAPiMF_00639. MurD. 1 hit.
InterProiIPR004101. Mur_ligase_C.
IPR013221. Mur_ligase_cen.
IPR016040. NAD(P)-bd_dom.
IPR005762. UDP-N-AcMur-Glu_ligase.
[Graphical view]
PfamiPF02875. Mur_ligase_C. 1 hit.
PF08245. Mur_ligase_M. 1 hit.
[Graphical view]
SUPFAMiSSF53244. SSF53244. 1 hit.
SSF53623. SSF53623. 1 hit.
TIGRFAMsiTIGR01087. murD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiMURD_ACAM1
AccessioniPrimary (citable) accession number: B0C915
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: September 7, 2016
This is version 61 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.