B0C8J3 (DXS_ACAM1) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
1-deoxy-D-xylulose-5-phosphate synthase
EC=2.2.1.7

Alternative name(s):
1-deoxyxylulose-5-phosphate synthase
Short name=DXP synthase
Short name=DXPS

Gene names

Name:	dxs
Ordered Locus Names:	AM1_5186

Organism

Acaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]

Taxonomic identifier

329726 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Chroococcales › Acaryochloris

Protein attributes

Sequence length	635 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP) By similarity. HAMAP MF_00315
Catalytic activity	Pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2. HAMAP MF_00315
Cofactor	Binds 1 thiamine pyrophosphate per subunit By similarity.
Pathway	Metabolic intermediate biosynthesis; 1-deoxy-D-xylulose 5-phosphate biosynthesis; 1-deoxy-D-xylulose 5-phosphate from D-glyceraldehyde 3-phosphate and pyruvate: step 1/1. HAMAP MF_00315
Subunit structure	Homodimer By similarity. HAMAP MF_00315
Sequence similarities	Belongs to the transketolase family. DXPS subfamily.

Ontologies

Keywords
Biological process	Isoprene biosynthesis Thiamine biosynthesis
Ligand	Thiamine pyrophosphate
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	terpenoid biosynthetic process Inferred from electronic annotation. Source: InterPro thiamine biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	1-deoxy-D-xylulose-5-phosphate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 635	635	1-deoxy-D-xylulose-5-phosphate synthase HAMAP MF_00315		PRO_1000079080

Sequences

	Sequence		Length	Mass (Da)
	B0C8J3 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: A14C483BA5AAB48D	FASTA	635	68,790
	10 20 30 40 50 60 MHLSEIVHPN QLHGLSISEL KQIANQIREK HLDTVATSGG HLGPGLGVVE LTLALYQTLD 70 80 90 100 110 120 LDQDKVVWDV GHQAYPHKLI TGRYERFHTL RQKDGVAGYL NRRESKFDHF GAGHASTSIS 130 140 150 160 170 180 SVLGMALARD AKGENFKTVA VIGDGAMTGG MALEAINHAG HLPHTRMLVI LNDNDMSISP 190 200 210 220 230 240 NVGAMSRYLN KMRLSPPIQF LSDNFEEQLK QLPFGEQVAP DLKRLKGGMK RLAVSKVGAV 250 260 270 280 290 300 FEELGFTYIG PVDGHSLEEL LATFKEAHLH EGPVLVHVAT TKGKGYAIAE QDQVSYHAQS 310 320 330 340 350 360 PFNLETGKAK PSNKPKPPSY SKVFAETLIK MAENDIRVVG ITAAMATGTG LDKLQAKLPK 370 380 390 400 410 420 QYIDVGIAEQ HAVTLAAGMA CEGMRPVVAI YSTFLQRGYD QIIHDVCIQN LPVFFCLDRA 430 440 450 460 470 480 GIVGADGPTH QGMYDIAYLR CLPNMVMMAP KDEAELQQML VTGINYTDGP IAMRYPRGSG 490 500 510 520 530 540 LGVGLMEEGW EPLPIGKAET LRHGDDVLLL AYGTMVNLAS QVADMLTEHG VRATVVNARF 550 560 570 580 590 600 AKPLDTELII PLAQKIGQVV TLEEGCLPGG FGSAVLEALM DHQVMAPVTR IGVPDQLVEH 610 620 630 ATPDQSKAEL GLTPAQVAER VLGLLKQKPA PSYVS

References

[1]

"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina." Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W. Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: MBIC 11017.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000828 Genomic DNA. Translation: ABW30148.1.
RefSeq	YP_001519467.1. NC_009925.1.
3D structure databases
ProteinModelPortal	B0C8J3.
ModBase	Search...
Protein-protein interaction databases
STRING	B0C8J3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5683982.
GenomeReviews	Gene locus AM1_5186 in contig CP000828_GR.
KEGG	amr:AM1_5186.
PATRIC	20624400. VBIAcaMar40141_4813.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG571647.
OMA	QYDISYM.
PhylomeDB	B0C8J3.
ProtClustDB	PRK05444.
Enzyme and pathway databases
BioCyc	AMAR329726:AM1_5186-MONOMER.
Family and domain databases
HAMAP	MF_00315. DXP_synth. [Tree]
InterPro	IPR005477. Dxylulose-5-P_synthase. IPR009014. Transketo_C/Pyr-ferredox_oxred. IPR015941. Transketolase-like_C. IPR005475. Transketolase-like_Pyr-bd. IPR020826. Transketolase_BS. IPR005476. Transketolase_C. IPR005474. Transketolase_N. [Graphical view]
Gene3D	G3DSA:3.40.50.920. Transketo_C_like. 1 hit.
KO	K01662.
Pfam	PF02779. Transket_pyr. 1 hit. PF02780. Transketolase_C. 1 hit. PF00456. Transketolase_N. 1 hit. [Graphical view]
SMART	SM00861. Transket_pyr. 1 hit. [Graphical view]
SUPFAM	SSF52922. Transketo_C_like. 1 hit.
TIGRFAMs	TIGR00204. Dxs. 1 hit.
PROSITE	PS00801. TRANSKETOLASE_1. 1 hit. PS00802. TRANSKETOLASE_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DXS_ACAM1

Accession

Primary (citable) accession number: B0C8J3

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 29 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program