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B0C6S1

- PANCY_ACAM1

UniProt

B0C6S1 - PANCY_ACAM1

Protein

Bifunctional pantoate ligase/cytidylate kinase

Gene

panC/cmk

Organism
Acaryochloris marina (strain MBIC 11017)
Status
Reviewed - Annotation score: 4 out of 5- Protein inferred from homologyi
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    • History
      Entry version 45 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.UniRule annotation
    Displays a CMP kinase activity.UniRule annotation

    Catalytic activityi

    ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate.UniRule annotation
    ATP + (d)CMP = ADP + (d)CDP.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei51 – 511Proton donorUniRule annotation
    Binding sitei75 – 751Beta-alanineUniRule annotation
    Binding sitei75 – 751PantoateUniRule annotation
    Binding sitei168 – 1681PantoateUniRule annotation
    Binding sitei191 – 1911ATP; via amide nitrogen and carbonyl oxygenUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi44 – 518ATPUniRule annotation
    Nucleotide bindingi162 – 1654ATPUniRule annotation
    Nucleotide bindingi199 – 2024ATPUniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. cytidylate kinase activity Source: UniProtKB-HAMAP
    3. pantoate-beta-alanine ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. pantothenate biosynthetic process Source: UniProtKB-HAMAP
    2. pyrimidine nucleotide metabolic process Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Kinase, Ligase, Transferase

    Keywords - Biological processi

    Pantothenate biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciAMAR329726:GCZJ-2609-MONOMER.
    UniPathwayiUPA00028; UER00005.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bifunctional pantoate ligase/cytidylate kinaseUniRule annotation
    Including the following 2 domains:
    Pantothenate synthetaseUniRule annotation (EC:6.3.2.1UniRule annotation)
    Short name:
    PSUniRule annotation
    Alternative name(s):
    Pantoate--beta-alanine ligaseUniRule annotation
    Pantoate-activating enzymeUniRule annotation
    Cytidylate kinaseUniRule annotation (EC:2.7.4.14UniRule annotation)
    Short name:
    CKUniRule annotation
    Alternative name(s):
    Cytidine monophosphate kinaseUniRule annotation
    Short name:
    CMP kinaseUniRule annotation
    Gene namesi
    Name:panC/cmkUniRule annotation
    Ordered Locus Names:AM1_2620
    OrganismiAcaryochloris marina (strain MBIC 11017)
    Taxonomic identifieri329726 [NCBI]
    Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesAcaryochloris
    ProteomesiUP000000268: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 525525Bifunctional pantoate ligase/cytidylate kinasePRO_0000333294Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi329726.AM1_2620.

    Structurei

    3D structure databases

    ProteinModelPortaliB0C6S1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 292292Pantoate--beta-alanine ligaseAdd
    BLAST
    Regioni293 – 525233Cytidylate kinaseAdd
    BLAST

    Sequence similaritiesi

    In the N-terminal section; belongs to the pantothenate synthetase family.UniRule annotation
    In the C-terminal section; belongs to the cytidylate kinase family. Type 1 subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0283.
    HOGENOMiHOG000233355.
    KOiK13799.
    OMAiLGEKDWQ.
    OrthoDBiEOG6Z6FZ4.

    Family and domain databases

    Gene3Di3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPiMF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProiIPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PANTHERiPTHR21299:SF2. PTHR21299:SF2. 1 hit.
    PfamiPF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view]
    SUPFAMiSSF52540. SSF52540. 1 hit.
    TIGRFAMsiTIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    B0C6S1-1 [UniParc]FASTAAdd to Basket

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    MDNVPIIRTV SGLRHFLRCF PGNLNTGASP SSTVIGQIGL VPTMGALHAG    50
    HLSLIQRARQ ENQCVIVSIF VNPLQFAAHE DLTEYPQTLN QDQALCQEQG 100
    VNTIFAPSTD TLLADAPLTQ VIPPASLTEY LCGPHRPDHF TGVATIVLKL 150
    LNIVQPTRAY FGQKDAQQLA IIQRLVQDFN LDVTIVPCKL IRDATGLALS 200
    SRNQYLNAQE AQQATILHHS LQAARHTFQG GSCDRNSVLA TVAQTLAKGP 250
    QVEVEYIDLV DPVTLQPLEQ ITTQGLVAIA ARVGSARLID NMLLDARLPI 300
    LAIDGPAGAG KSTVTRRCAQ AIGLQYLDTG AMYRAVAWLA LDQQVEVSDP 350
    FAIADLVEDC QIELKPHADP QQQPQVWVNH QEVTQAIRTP DVTALVSAVA 400
    AQPPVREALV KQQQRLGRQG GLIAEGRDIG TNVFPDAGLK IFLTASIEER 450
    ARRRQQDLKN QNLPPQTQSE LEDLIASRDQ QDSQREFAPL RKAYDAVEIN 500
    TDGMTIEQVI TRITTLYQER FPDRA 525
    Length:525
    Mass (Da):57,533
    Last modified:February 26, 2008 - v1
    Checksum:iEE2A7EA486E0C84A
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000828 Genomic DNA. Translation: ABW27627.1.
    RefSeqiYP_001516941.1. NC_009925.1.

    Genome annotation databases

    EnsemblBacteriaiABW27627; ABW27627; AM1_2620.
    GeneIDi5681432.
    KEGGiamr:AM1_2620.
    PATRICi20619536. VBIAcaMar40141_2401.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000828 Genomic DNA. Translation: ABW27627.1 .
    RefSeqi YP_001516941.1. NC_009925.1.

    3D structure databases

    ProteinModelPortali B0C6S1.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 329726.AM1_2620.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABW27627 ; ABW27627 ; AM1_2620 .
    GeneIDi 5681432.
    KEGGi amr:AM1_2620.
    PATRICi 20619536. VBIAcaMar40141_2401.

    Phylogenomic databases

    eggNOGi COG0283.
    HOGENOMi HOG000233355.
    KOi K13799.
    OMAi LGEKDWQ.
    OrthoDBi EOG6Z6FZ4.

    Enzyme and pathway databases

    UniPathwayi UPA00028 ; UER00005 .
    BioCyci AMAR329726:GCZJ-2609-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.300. 1 hit.
    3.40.50.620. 1 hit.
    HAMAPi MF_00158. PanC.
    MF_00238. Cytidyl_kinase_type1.
    MF_01349. PanCY.
    InterProi IPR004821. Cyt_trans-like.
    IPR003136. Cytidylate_kin.
    IPR011994. Cytidylate_kinase_dom.
    IPR027417. P-loop_NTPase.
    IPR003721. Pantoate_ligase.
    IPR024894. Pantoate_ligase/cytidylate_kin.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    PANTHERi PTHR21299:SF2. PTHR21299:SF2. 1 hit.
    Pfami PF02224. Cytidylate_kin. 1 hit.
    PF02569. Pantoate_ligase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52540. SSF52540. 1 hit.
    TIGRFAMsi TIGR00017. cmk. 1 hit.
    TIGR00125. cyt_tran_rel. 1 hit.
    TIGR00018. panC. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: MBIC 11017.

    Entry informationi

    Entry nameiPANCY_ACAM1
    AccessioniPrimary (citable) accession number: B0C6S1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 45 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Multifunctional enzyme, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3