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B0C4B4

- NU4C_ACAM1

UniProt

B0C4B4 - NU4C_ACAM1

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Protein

NAD(P)H-quinone oxidoreductase chain 4

Gene

ndhD

Organism
Acaryochloris marina (strain MBIC 11017)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.UniRule annotation

GO - Molecular functioni

  1. NADH dehydrogenase (ubiquinone) activity Source: InterPro
  2. quinone binding Source: UniProtKB-KW

GO - Biological processi

  1. mitochondrial electron transport, NADH to ubiquinone Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD, NADP, Plastoquinone

Enzyme and pathway databases

BioCyciAMAR329726:GCZJ-2486-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H-quinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.-UniRule annotation)
Alternative name(s):
NAD(P)H dehydrogenase I, chain 4UniRule annotation
NDH-1, chain 4UniRule annotation
Gene namesi
Name:ndhDUniRule annotation
Ordered Locus Names:AM1_2497
OrganismiAcaryochloris marina (strain MBIC 11017)
Taxonomic identifieri329726 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesAcaryochloris
ProteomesiUP000000268: Chromosome

Subcellular locationi

Cellular thylakoid membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. thylakoid Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 534534NAD(P)H-quinone oxidoreductase chain 4PRO_0000343228Add
BLAST

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi329726.AM1_2497.

Structurei

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei6 – 2621HelicalUniRule annotationAdd
BLAST
Transmembranei38 – 5821HelicalUniRule annotationAdd
BLAST
Transmembranei91 – 11121HelicalUniRule annotationAdd
BLAST
Transmembranei117 – 13721HelicalUniRule annotationAdd
BLAST
Transmembranei138 – 15821HelicalUniRule annotationAdd
BLAST
Transmembranei171 – 19121HelicalUniRule annotationAdd
BLAST
Transmembranei214 – 23421HelicalUniRule annotationAdd
BLAST
Transmembranei245 – 26521HelicalUniRule annotationAdd
BLAST
Transmembranei279 – 29921HelicalUniRule annotationAdd
BLAST
Transmembranei316 – 33621HelicalUniRule annotationAdd
BLAST
Transmembranei337 – 35721HelicalUniRule annotationAdd
BLAST
Transmembranei377 – 39923HelicalUniRule annotationAdd
BLAST
Transmembranei419 – 43921HelicalUniRule annotationAdd
BLAST
Transmembranei466 – 48621HelicalUniRule annotationAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1008.
HOGENOMiHOG000100683.
KOiK05575.
OMAiFFMVGAT.
OrthoDBiEOG647TZ6.

Family and domain databases

HAMAPiMF_00491. NDH1_NuoM.
InterProiIPR022997. NADH_Q_OxRdtase_chain4.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamiPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSiPR01437. NUOXDRDTASE4.
TIGRFAMsiTIGR01972. NDH_I_M. 1 hit.

Sequencei

Sequence statusi: Complete.

B0C4B4-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNPDTFPWLS TLIFFPIMAT VALPFIPDPK GKGDPIRWYA LVIGLIDFVL
60 70 80 90 100
LIYAFYTQYD FAESGLQMVE HYDWLPQLGV QWSVGADGLS MPLILLTGFI
110 120 130 140 150
TSLAILASWP VTYKPRLFYF LILAMYGGQI AVFAVQDLLV FFLVWELELV
160 170 180 190 200
PVYLLLSIWG GYKRLYAATK FILYTAISSL FILVAALAMA FFGPDLTFDL
210 220 230 240 250
QSLAAKDYPL TFQLLCYTGF LVAFAVKLPI VPLHTWLPDA HGEATAPVHM
260 270 280 290 300
LLAGILLKMG GYALIRMNVE LLPDAHAYFA PALIILGVVN IIYAALTSFA
310 320 330 340 350
QRNLKRKIAY SSISHMGFVL IGIASFTDLG MSGAVLQMVS HGLIGASLFF
360 370 380 390 400
LVGATYDRTH TLILEEMGGV AQNMPKIFAM FTTCSMASLA LPGMSGFVAE
410 420 430 440 450
LMVFVGLATS DAYSLAFRVP VVILAGIGVI LTPIYLLSML REIFYGPENK
460 470 480 490 500
ELTSHEKLVD AEPREIFVIA CLLVPIIGIG LYPKIITQIY DAKTTQLVAY
510 520 530
IRPSVPSIAM REAATVASVS DIEMDSSYQA PAIK
Length:534
Mass (Da):58,668
Last modified:February 26, 2008 - v1
Checksum:iEAA6AEA11E9F436F
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000828 Genomic DNA. Translation: ABW27505.1.
RefSeqiWP_012162965.1. NC_009925.1.
YP_001516819.1. NC_009925.1.

Genome annotation databases

EnsemblBacteriaiABW27505; ABW27505; AM1_2497.
GeneIDi5681309.
KEGGiamr:AM1_2497.
PATRICi20619304. VBIAcaMar40141_2285.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000828 Genomic DNA. Translation: ABW27505.1 .
RefSeqi WP_012162965.1. NC_009925.1.
YP_001516819.1. NC_009925.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 329726.AM1_2497.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW27505 ; ABW27505 ; AM1_2497 .
GeneIDi 5681309.
KEGGi amr:AM1_2497.
PATRICi 20619304. VBIAcaMar40141_2285.

Phylogenomic databases

eggNOGi COG1008.
HOGENOMi HOG000100683.
KOi K05575.
OMAi FFMVGAT.
OrthoDBi EOG647TZ6.

Enzyme and pathway databases

BioCyci AMAR329726:GCZJ-2486-MONOMER.

Family and domain databases

HAMAPi MF_00491. NDH1_NuoM.
InterProi IPR022997. NADH_Q_OxRdtase_chain4.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view ]
Pfami PF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view ]
PRINTSi PR01437. NUOXDRDTASE4.
TIGRFAMsi TIGR01972. NDH_I_M. 1 hit.
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBIC 11017.

Entry informationi

Entry nameiNU4C_ACAM1
AccessioniPrimary (citable) accession number: B0C4B4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3