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B0C4B4 (NU4C_ACAM1) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 44. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD(P)H-quinone oxidoreductase chain 4

EC=1.6.5.-
Alternative name(s):
NAD(P)H dehydrogenase I, chain 4
NDH-1, chain 4
Gene names
Name:ndhD
Ordered Locus Names:AM1_2497
OrganismAcaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]
Taxonomic identifier329726 [NCBI]
Taxonomic lineageBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesAcaryochloris

Protein attributes

Sequence length534 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient By similarity. HAMAP-Rule MF_00491

Catalytic activity

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol. HAMAP-Rule MF_00491

Subcellular location

Cellular thylakoid membrane; Multi-pass membrane protein By similarity HAMAP-Rule MF_00491.

Sequence similarities

Belongs to the complex I subunit 4 family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 534534NAD(P)H-quinone oxidoreductase chain 4 HAMAP-Rule MF_00491
PRO_0000343228

Regions

Transmembrane6 – 2621Helical; Potential
Transmembrane38 – 5821Helical; Potential
Transmembrane91 – 11121Helical; Potential
Transmembrane117 – 13721Helical; Potential
Transmembrane138 – 15821Helical; Potential
Transmembrane171 – 19121Helical; Potential
Transmembrane214 – 23421Helical; Potential
Transmembrane245 – 26521Helical; Potential
Transmembrane279 – 29921Helical; Potential
Transmembrane316 – 33621Helical; Potential
Transmembrane337 – 35721Helical; Potential
Transmembrane377 – 39923Helical; Potential
Transmembrane419 – 43921Helical; Potential
Transmembrane466 – 48621Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B0C4B4 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: EAA6AEA11E9F436F

FASTA53458,668
        10         20         30         40         50         60 
MNPDTFPWLS TLIFFPIMAT VALPFIPDPK GKGDPIRWYA LVIGLIDFVL LIYAFYTQYD 

        70         80         90        100        110        120 
FAESGLQMVE HYDWLPQLGV QWSVGADGLS MPLILLTGFI TSLAILASWP VTYKPRLFYF 

       130        140        150        160        170        180 
LILAMYGGQI AVFAVQDLLV FFLVWELELV PVYLLLSIWG GYKRLYAATK FILYTAISSL 

       190        200        210        220        230        240 
FILVAALAMA FFGPDLTFDL QSLAAKDYPL TFQLLCYTGF LVAFAVKLPI VPLHTWLPDA 

       250        260        270        280        290        300 
HGEATAPVHM LLAGILLKMG GYALIRMNVE LLPDAHAYFA PALIILGVVN IIYAALTSFA 

       310        320        330        340        350        360 
QRNLKRKIAY SSISHMGFVL IGIASFTDLG MSGAVLQMVS HGLIGASLFF LVGATYDRTH 

       370        380        390        400        410        420 
TLILEEMGGV AQNMPKIFAM FTTCSMASLA LPGMSGFVAE LMVFVGLATS DAYSLAFRVP 

       430        440        450        460        470        480 
VVILAGIGVI LTPIYLLSML REIFYGPENK ELTSHEKLVD AEPREIFVIA CLLVPIIGIG 

       490        500        510        520        530 
LYPKIITQIY DAKTTQLVAY IRPSVPSIAM REAATVASVS DIEMDSSYQA PAIK 

« Hide

References

[1]"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina."
Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. expand/collapse author list , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W.
Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: MBIC 11017.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000828 Genomic DNA. Translation: ABW27505.1.
RefSeqYP_001516819.1. NC_009925.1.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING329726.AM1_2497.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABW27505; ABW27505; AM1_2497.
GeneID5681309.
KEGGamr:AM1_2497.
PATRIC20619304. VBIAcaMar40141_2285.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1008.
HOGENOMHOG000100683.
KOK05575.
OMAFFMVGAT.
OrthoDBEOG647TZ6.

Enzyme and pathway databases

BioCycAMAR329726:GCZJ-2486-MONOMER.

Family and domain databases

HAMAPMF_00491. NDH1_NuoM.
InterProIPR022997. NADH_Q_OxRdtase_chain4.
IPR010227. NADH_Q_OxRdtase_chainM/4.
IPR001750. NADH_UbQ/plastoQ_OxRdtase.
IPR003918. NADH_UbQ_OxRdtase.
IPR000260. NADH_UbQ_OxRdtase_chain4_N.
[Graphical view]
PfamPF00361. Oxidored_q1. 1 hit.
PF01059. Oxidored_q5_N. 1 hit.
[Graphical view]
PRINTSPR01437. NUOXDRDTASE4.
TIGRFAMsTIGR01972. NDH_I_M. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNU4C_ACAM1
AccessionPrimary (citable) accession number: B0C4B4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 44 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families