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Protein

NAD(P)H-quinone oxidoreductase chain 4

Gene

ndhD

Organism
Acaryochloris marina (strain MBIC 11017)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

NDH-1 shuttles electrons from NAD(P)H, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be plastoquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient.UniRule annotation

Catalytic activityi

NAD(P)H + plastoquinone = NAD(P)+ + plastoquinol.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD, NADP, Plastoquinone

Names & Taxonomyi

Protein namesi
Recommended name:
NAD(P)H-quinone oxidoreductase chain 4UniRule annotation (EC:1.6.5.-UniRule annotation)
Alternative name(s):
NAD(P)H dehydrogenase I, chain 4UniRule annotation
NDH-1, chain 4UniRule annotation
Gene namesi
Name:ndhDUniRule annotation
Ordered Locus Names:AM1_2497
OrganismiAcaryochloris marina (strain MBIC 11017)
Taxonomic identifieri329726 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesAcaryochloridaceaeAcaryochloris
Proteomesi
  • UP000000268 Componenti: Chromosome

Subcellular locationi

  • Cellular thylakoid membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei6 – 26HelicalUniRule annotationAdd BLAST21
Transmembranei38 – 58HelicalUniRule annotationAdd BLAST21
Transmembranei91 – 111HelicalUniRule annotationAdd BLAST21
Transmembranei117 – 137HelicalUniRule annotationAdd BLAST21
Transmembranei138 – 158HelicalUniRule annotationAdd BLAST21
Transmembranei171 – 191HelicalUniRule annotationAdd BLAST21
Transmembranei214 – 234HelicalUniRule annotationAdd BLAST21
Transmembranei245 – 265HelicalUniRule annotationAdd BLAST21
Transmembranei279 – 299HelicalUniRule annotationAdd BLAST21
Transmembranei316 – 336HelicalUniRule annotationAdd BLAST21
Transmembranei337 – 357HelicalUniRule annotationAdd BLAST21
Transmembranei377 – 399HelicalUniRule annotationAdd BLAST23
Transmembranei419 – 439HelicalUniRule annotationAdd BLAST21
Transmembranei466 – 486HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Membrane, Thylakoid

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003432281 – 534NAD(P)H-quinone oxidoreductase chain 4Add BLAST534

Keywords - PTMi

Quinone

Interactioni

Protein-protein interaction databases

STRINGi329726.AM1_2497

Family & Domainsi

Sequence similaritiesi

Belongs to the complex I subunit 4 family.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105C8S Bacteria
COG1008 LUCA
HOGENOMiHOG000100683
KOiK05575
OMAiTAPVHML
OrthoDBiPOG091H09WR

Family and domain databases

HAMAPiMF_00491 NDH1_NuoM, 1 hit
InterProiView protein in InterPro
IPR000260 NADH4_N
IPR022997 NADH_Q_OxRdtase_chain4
IPR010227 NADH_Q_OxRdtase_chainM/4
IPR003918 NADH_UbQ_OxRdtase
IPR001750 ND/Mrp_mem
PANTHERiPTHR43507 PTHR43507, 1 hit
PTHR43507:SF3 PTHR43507:SF3, 1 hit
PfamiView protein in Pfam
PF01059 Oxidored_q5_N, 1 hit
PF00361 Proton_antipo_M, 1 hit
PRINTSiPR01437 NUOXDRDTASE4
TIGRFAMsiTIGR01972 NDH_I_M, 1 hit

Sequencei

Sequence statusi: Complete.

B0C4B4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPDTFPWLS TLIFFPIMAT VALPFIPDPK GKGDPIRWYA LVIGLIDFVL
60 70 80 90 100
LIYAFYTQYD FAESGLQMVE HYDWLPQLGV QWSVGADGLS MPLILLTGFI
110 120 130 140 150
TSLAILASWP VTYKPRLFYF LILAMYGGQI AVFAVQDLLV FFLVWELELV
160 170 180 190 200
PVYLLLSIWG GYKRLYAATK FILYTAISSL FILVAALAMA FFGPDLTFDL
210 220 230 240 250
QSLAAKDYPL TFQLLCYTGF LVAFAVKLPI VPLHTWLPDA HGEATAPVHM
260 270 280 290 300
LLAGILLKMG GYALIRMNVE LLPDAHAYFA PALIILGVVN IIYAALTSFA
310 320 330 340 350
QRNLKRKIAY SSISHMGFVL IGIASFTDLG MSGAVLQMVS HGLIGASLFF
360 370 380 390 400
LVGATYDRTH TLILEEMGGV AQNMPKIFAM FTTCSMASLA LPGMSGFVAE
410 420 430 440 450
LMVFVGLATS DAYSLAFRVP VVILAGIGVI LTPIYLLSML REIFYGPENK
460 470 480 490 500
ELTSHEKLVD AEPREIFVIA CLLVPIIGIG LYPKIITQIY DAKTTQLVAY
510 520 530
IRPSVPSIAM REAATVASVS DIEMDSSYQA PAIK
Length:534
Mass (Da):58,668
Last modified:February 26, 2008 - v1
Checksum:iEAA6AEA11E9F436F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000828 Genomic DNA Translation: ABW27505.1
RefSeqiWP_012162965.1, NC_009925.1

Genome annotation databases

EnsemblBacteriaiABW27505; ABW27505; AM1_2497
KEGGiamr:AM1_2497

Similar proteinsi

Entry informationi

Entry nameiNU4C_ACAM1
AccessioniPrimary (citable) accession number: B0C4B4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 1, 2008
Last sequence update: February 26, 2008
Last modified: April 25, 2018
This is version 65 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health