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B0C1T8

- UPPP_ACAM1

UniProt

B0C1T8 - UPPP_ACAM1

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Protein

Undecaprenyl-diphosphatase

Gene
uppP, AM1_1064
Organism
Acaryochloris marina (strain MBIC 11017)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin By similarity.UniRule annotation

Catalytic activityi

Ditrans,octacis-undecaprenyl diphosphate + H2O = ditrans,octacis-undecaprenyl phosphate + phosphate.UniRule annotation

GO - Molecular functioni

  1. undecaprenyl-diphosphatase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. dephosphorylation Source: InterPro
  2. peptidoglycan biosynthetic process Source: UniProtKB-KW
  3. regulation of cell shape Source: UniProtKB-KW
  4. response to antibiotic Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Keywords - Biological processi

Antibiotic resistance, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

BioCyciAMAR329726:GCZJ-1054-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Undecaprenyl-diphosphatase (EC:3.6.1.27)
Alternative name(s):
Bacitracin resistance protein
Undecaprenyl pyrophosphate phosphatase
Gene namesi
Name:uppP
Ordered Locus Names:AM1_1064
OrganismiAcaryochloris marina (strain MBIC 11017)
Taxonomic identifieri329726 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesAcaryochloris
ProteomesiUP000000268: Chromosome

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1 – 2121Helical; Reviewed predictionAdd
BLAST
Transmembranei40 – 6021Helical; Reviewed predictionAdd
BLAST
Transmembranei90 – 11021Helical; Reviewed predictionAdd
BLAST
Transmembranei113 – 13321Helical; Reviewed predictionAdd
BLAST
Transmembranei145 – 16521Helical; Reviewed predictionAdd
BLAST
Transmembranei188 – 20821Helical; Reviewed predictionAdd
BLAST
Transmembranei217 – 23721Helical; Reviewed predictionAdd
BLAST
Transmembranei245 – 26521Helical; Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 266266Undecaprenyl-diphosphataseUniRule annotationPRO_1000083972Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi329726.AM1_1064.

Family & Domainsi

Sequence similaritiesi

Belongs to the UppP family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1968.
HOGENOMiHOG000218357.
KOiK06153.
OMAiFNDAHAK.
OrthoDBiEOG6QP13M.

Family and domain databases

HAMAPiMF_01006. Undec_diphosphatase.
InterProiIPR003824. UppP.
[Graphical view]
PfamiPF02673. BacA. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0C1T8-1 [UniParc]FASTAAdd to Basket

« Hide

MTLLQAIILG IVQGLTEFLP VSSSGHLVLA SYYLGWWEKL PLYVDIATNT    50
GTFFAVLVVL RKDVWQALSG FFAGLTSSTA RQQEGWRMAL LVVLGSIPTA 100
MIGLGLKPIF EELNQPLYVS FALIVTGLVL WFTPKSGLKR NAMSLSWLDA 150
TIGGIAQGCA VIPGISRSGS TISTMLWRGA TSDLAPRFSF LMYLVVSFGV 200
AILGIDEVRE EGLQLAPLLG MIIASFVTGY IALLWLFSVL KKGQFKWFAP 250
YLWVVAAITL IKVAMG 266
Length:266
Mass (Da):28,929
Last modified:February 26, 2008 - v1
Checksum:i5A487CB07B7F9F79
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000828 Genomic DNA. Translation: ABW26104.1.
RefSeqiYP_001515418.1. NC_009925.1.

Genome annotation databases

EnsemblBacteriaiABW26104; ABW26104; AM1_1064.
GeneIDi5679889.
KEGGiamr:AM1_1064.
PATRICi20616584. VBIAcaMar40141_0940.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000828 Genomic DNA. Translation: ABW26104.1 .
RefSeqi YP_001515418.1. NC_009925.1.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 329726.AM1_1064.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABW26104 ; ABW26104 ; AM1_1064 .
GeneIDi 5679889.
KEGGi amr:AM1_1064.
PATRICi 20616584. VBIAcaMar40141_0940.

Phylogenomic databases

eggNOGi COG1968.
HOGENOMi HOG000218357.
KOi K06153.
OMAi FNDAHAK.
OrthoDBi EOG6QP13M.

Enzyme and pathway databases

BioCyci AMAR329726:GCZJ-1054-MONOMER.

Family and domain databases

HAMAPi MF_01006. Undec_diphosphatase.
InterProi IPR003824. UppP.
[Graphical view ]
Pfami PF02673. BacA. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBIC 11017.

Entry informationi

Entry nameiUPPP_ACAM1
AccessioniPrimary (citable) accession number: B0C1T8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: May 14, 2014
This is version 42 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Miscellaneous

Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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