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Protein

Leucine--tRNA ligase

Gene

leuS

Organism
Acaryochloris marina (strain MBIC 11017)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei617 – 6171ATPUniRule annotation

GO - Molecular functioni

  1. aminoacyl-tRNA editing activity Source: InterPro
  2. ATP binding Source: UniProtKB-HAMAP
  3. leucine-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. leucyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciAMAR329726:GCZJ-1027-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine--tRNA ligaseUniRule annotation (EC:6.1.1.4UniRule annotation)
Alternative name(s):
Leucyl-tRNA synthetaseUniRule annotation
Short name:
LeuRSUniRule annotation
Gene namesi
Name:leuSUniRule annotation
Ordered Locus Names:AM1_1037
OrganismiAcaryochloris marina (strain MBIC 11017)
Taxonomic identifieri329726 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaOscillatoriophycideaeChroococcalesAcaryochloris
ProteomesiUP000000268 Componenti: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 855855Leucine--tRNA ligasePRO_1000074823Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi329726.AM1_1037.

Structurei

3D structure databases

ProteinModelPortaliB0C1R1.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi42 – 5211"HIGH" regionAdd
BLAST
Motifi614 – 6185"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0C1R1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESRYNPTEI EPKWQASWAK QGLDATPEDT SKPKFYALSM FPYPSGSLHV
60 70 80 90 100
GHTRNYVITD VIARLKRMQG YRVLQPMGWD AFGLPAENAA IARGIHPAEW
110 120 130 140 150
TYANMAQMKK QLEPLGLSID WSREIATCSP DYYRWTQWIF LQFLDMGLAY
160 170 180 190 200
QKEAAVNWDP VDQTVLANEQ VDNEGRSWRS GAKVERKLLR QWFLKITDYA
210 220 230 240 250
EELLTDLDKL TGWPERVKTM QANWIGKSVG AYLEFPIVGM DEKVAVFTTR
260 270 280 290 300
PDTVYGVTYV VLAPEHPLTP QVTSKAQKKA VDKFIEAVGA ESEMDRTAED
310 320 330 340 350
KPKKGIPTGG KAINPFTGEE IPIWIADYVL YEYGTGAVMG VPAHDTRDFV
360 370 380 390 400
FAQQNKLPIQ TVIVPEGGDA ETPLEAAYTE PGLMVNSGEF DGKVSTEGKQ
410 420 430 440 450
AIIAKAETKG WGKARVQYRL RDWLISRQRY WGVPIPVIHC PNCGAVPVPE
460 470 480 490 500
ADLPVELPED VEFSAQGGSP LAKLESWVNV ACPNCGADAK RETDTMDTFI
510 520 530 540 550
DSSWYFLRYP DAKNDKAVFD SAKTNDWLPV DQYVGGIEHA ILHLLYSRFF
560 570 580 590 600
TKVMRDRKLL NFDEPFKKLL TQGMVQALTY KNPETGQYIA PINVDADDPK
610 620 630 640 650
DPETGAPLEA FYEKMSKSKY NGVPPEEVTN KYGADTARLF TLFKAPPEKD
660 670 680 690 700
LEWEGADVEG QFRFLNRVWR LVSEHAAQAK GKKAKVNKAK LSKTEKELRR
710 720 730 740 750
SIHIAIKETS EDLDGDYQFN TAVSELMKLS NALSDSKEKA SPVYAEGVET
760 770 780 790 800
LLLLLTPFAP HISEELWENL GHSESILGQT WPQVDEEALV ADEITLVIQI
810 820 830 840 850
MGKTRGTIQV PAGSSREDLE QLARESEVAQ RYIAGKEVKK VIVVPGKLVN

FVVPK
Length:855
Mass (Da):95,949
Last modified:February 26, 2008 - v1
Checksum:i6BEA950C874A35F9
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000828 Genomic DNA. Translation: ABW26077.1.
RefSeqiYP_001515391.1. NC_009925.1.

Genome annotation databases

EnsemblBacteriaiABW26077; ABW26077; AM1_1037.
KEGGiamr:AM1_1037.
PATRICi20616540. VBIAcaMar40141_0918.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000828 Genomic DNA. Translation: ABW26077.1.
RefSeqiYP_001515391.1. NC_009925.1.

3D structure databases

ProteinModelPortaliB0C1R1.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi329726.AM1_1037.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABW26077; ABW26077; AM1_1037.
KEGGiamr:AM1_1037.
PATRICi20616540. VBIAcaMar40141_0918.

Phylogenomic databases

eggNOGiCOG0495.
HOGENOMiHOG000200747.
KOiK01869.
OMAiQSSWYFL.
OrthoDBiEOG63Z74X.

Enzyme and pathway databases

BioCyciAMAR329726:GCZJ-1027-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.40.50.620. 3 hits.
3.90.740.10. 1 hit.
HAMAPiMF_00049_B. Leu_tRNA_synth_B.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR002300. aa-tRNA-synth_Ia.
IPR002302. Leu-tRNA-ligase.
IPR025709. Leu_tRNA-synth_edit.
IPR013155. M/V/L/I-tRNA-synth_anticd-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
IPR009008. Val/Leu/Ile-tRNA-synth_edit.
[Graphical view]
PANTHERiPTHR11946:SF7. PTHR11946:SF7. 1 hit.
PfamiPF08264. Anticodon_1. 1 hit.
PF00133. tRNA-synt_1. 3 hits.
PF13603. tRNA-synt_1_2. 1 hit.
[Graphical view]
PRINTSiPR00985. TRNASYNTHLEU.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF50677. SSF50677. 1 hit.
TIGRFAMsiTIGR00396. leuS_bact. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: MBIC 11017.

Entry informationi

Entry nameiSYL_ACAM1
AccessioniPrimary (citable) accession number: B0C1R1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: April 1, 2015
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.