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Protein

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Gene

mraY

Organism
Acaryochloris marina (strain MBIC 11017)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan.UniRule annotation

Catalytic activityi

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol.UniRule annotation

Pathwayi: peptidoglycan biosynthesis

This protein is involved in the pathway peptidoglycan biosynthesis, which is part of Cell wall biogenesis.UniRule annotation
View all proteins of this organism that are known to be involved in the pathway peptidoglycan biosynthesis and in Cell wall biogenesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionTransferase
Biological processCell cycle, Cell division, Cell shape, Cell wall biogenesis/degradation, Peptidoglycan synthesis

Enzyme and pathway databases

UniPathwayiUPA00219.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferaseUniRule annotation (EC:2.7.8.13UniRule annotation)
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferaseUniRule annotation
Gene namesi
Name:mraYUniRule annotation
Ordered Locus Names:AM1_5787
OrganismiAcaryochloris marina (strain MBIC 11017)
Taxonomic identifieri329726 [NCBI]
Taxonomic lineageiBacteriaCyanobacteriaSynechococcalesAcaryochloridaceaeAcaryochloris
Proteomesi
  • UP000000268 Componenti: Chromosome

Subcellular locationi

  • Cell inner membrane UniRule annotation; Multi-pass membrane protein UniRule annotation

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei19 – 39HelicalUniRule annotationAdd BLAST21
Transmembranei48 – 68HelicalUniRule annotationAdd BLAST21
Transmembranei95 – 115HelicalUniRule annotationAdd BLAST21
Transmembranei119 – 139HelicalUniRule annotationAdd BLAST21
Transmembranei155 – 175HelicalUniRule annotationAdd BLAST21
Transmembranei180 – 200HelicalUniRule annotationAdd BLAST21
Transmembranei227 – 247HelicalUniRule annotationAdd BLAST21
Transmembranei284 – 304HelicalUniRule annotationAdd BLAST21
Transmembranei349 – 369HelicalUniRule annotationAdd BLAST21

GO - Cellular componenti

Keywords - Cellular componenti

Cell inner membrane, Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003325221 – 371Phospho-N-acetylmuramoyl-pentapeptide-transferaseAdd BLAST371

Interactioni

Protein-protein interaction databases

STRINGi329726.AM1_5787.

Family & Domainsi

Sequence similaritiesi

Belongs to the glycosyltransferase 4 family. MraY subfamily.UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG4105CPY. Bacteria.
COG0472. LUCA.
HOGENOMiHOG000275124.
KOiK01000.
OMAiLMSPLHH.
OrthoDBiPOG091H00VH.

Family and domain databases

CDDicd06852. GT_MraY. 1 hit.
HAMAPiMF_00038. MraY. 1 hit.
InterProiView protein in InterPro
IPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
PANTHERiPTHR22926. PTHR22926. 1 hit.
PfamiView protein in Pfam
PF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
TIGRFAMsiTIGR00445. mraY. 1 hit.
PROSITEiView protein in PROSITE
PS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.

Sequencei

Sequence statusi: Complete.

B0BZI7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLANKTTAS TRSGAGRNLY WLLLLCLSGV ALATDIYSGR IDTPALTIVA
60 70 80 90 100
PLWTSTLVVT LLGFWAVPML RSLKASQVIQ EDGPQSHLKK AGTPTMGGIF
110 120 130 140 150
FMPVALVLGW AWVAANSVNL LEVSAAVLLT LCLGLVGWFD DWQILRKKSN
160 170 180 190 200
KGISAKLRLG IELGSGLIFG LWLFLTRSDI SGLALPFGLS LPIGVLFLAI
210 220 230 240 250
STFVVAAESN AVNLTDGMDG LAAGTSAIAF LGLALVVAPS WPGLMIFCAC
260 270 280 290 300
FSGSCLGFLA HNHNPAQVFM GDTGSLALGG ALAAVGLITN TLWALLILSG
310 320 330 340 350
LFLVESLSVI AQVTYYKATK GPDGVGKRLF KMSPIHHHFE QSGWPEVRVV
360 370
STFYACVAVL AVAACGLNAL S
Length:371
Mass (Da):38,993
Last modified:February 26, 2008 - v1
Checksum:i7FED6C399413FABE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000828 Genomic DNA. Translation: ABW30732.1.
RefSeqiWP_012165946.1. NC_009925.1.

Genome annotation databases

EnsemblBacteriaiABW30732; ABW30732; AM1_5787.
KEGGiamr:AM1_5787.

Similar proteinsi

Entry informationi

Entry nameiMRAY_ACAM1
AccessioniPrimary (citable) accession number: B0BZI7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: February 26, 2008
Last modified: June 7, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families