Reviewed, UniProtKB/Swiss-Prot B0BZI7 (MRAY_ACAM1)

Names and origin

Protein names

Recommended name:
    Phospho-N-acetylmuramoyl-pentapeptide-transferase
    EC=2.7.8.13
Alternative name(s):
    UDP-MurNAc-pentapeptide phosphotransferase

Gene names

Name:	mraY
Ordered Locus Names:	AM1_5787

Organism

Acaryochloris marina (strain MBIC 11017) [Complete proteome] [HAMAP]

Taxonomic identifier

329726 [NCBI]

Taxonomic lineage

Bacteria › Cyanobacteria › Acaryochloris

Protein attributes

Sequence length	371 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity.
Catalytic activity	UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038
Subcellular location	Cell inner membrane; Multi-pass membrane protein By similarity.
Sequence similarities	Belongs to the glycosyltransferase 4 family. MraY subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cell inner membrane Cell membrane Membrane
Domain	Transmembrane
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell plasma membrane Inferred from electronic annotation. Source: HAMAP
Molecular function	phospho-N-acetylmuramoyl-pentapeptide-transferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 371	371	Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038		PRO_0000332522
Regions
	Transmembrane	19 – 39	21	Potential
	Transmembrane	48 – 68	21	Potential
	Transmembrane	95 – 115	21	Potential
	Transmembrane	119 – 139	21	Potential
	Transmembrane	155 – 175	21	Potential
	Transmembrane	180 – 200	21	Potential
	Transmembrane	227 – 247	21	Potential
	Transmembrane	284 – 304	21	Potential
	Transmembrane	349 – 369	21	Potential

Sequences

	Sequence		Length	Mass (Da)
	B0BZI7-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 7FED6C399413FABE	FASTA	371	38,993
	10 20 30 40 50 60 MVLANKTTAS TRSGAGRNLY WLLLLCLSGV ALATDIYSGR IDTPALTIVA PLWTSTLVVT 70 80 90 100 110 120 LLGFWAVPML RSLKASQVIQ EDGPQSHLKK AGTPTMGGIF FMPVALVLGW AWVAANSVNL 130 140 150 160 170 180 LEVSAAVLLT LCLGLVGWFD DWQILRKKSN KGISAKLRLG IELGSGLIFG LWLFLTRSDI 190 200 210 220 230 240 SGLALPFGLS LPIGVLFLAI STFVVAAESN AVNLTDGMDG LAAGTSAIAF LGLALVVAPS 250 260 270 280 290 300 WPGLMIFCAC FSGSCLGFLA HNHNPAQVFM GDTGSLALGG ALAAVGLITN TLWALLILSG 310 320 330 340 350 360 LFLVESLSVI AQVTYYKATK GPDGVGKRLF KMSPIHHHFE QSGWPEVRVV STFYACVAVL 370 AVAACGLNAL S

References

[1]

"Niche adaptation and genome expansion in the chlorophyll d-producing cyanobacterium Acaryochloris marina." Swingley W.D., Chen M., Cheung P.C., Conrad A.L., Dejesa L.C., Hao J., Honchak B.M., Karbach L.E., Kurdoglu A., Lahiri S., Mastrian S.D., Miyashita H., Page L., Ramakrishna P., Satoh S., Sattley W.M., Shimada Y., Taylor H.L. , Tomo T., Tsuchiya T., Wang Z.T., Raymond J., Mimuro M., Blankenship R.E., Touchman J.W. Proc. Natl. Acad. Sci. U.S.A. 105:2005-2010(2008) [PubMed: 18252824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000828 Genomic DNA. Translation: ABW30732.1.
RefSeq	YP_001520051.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5684574.
GenomeReviews	Gene locus AM1_5787 in contig CP000828_GR.
KEGG	amr:AM1_5787.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	AGGLMFY.
Family and domain databases
HAMAP	MF_00038. [Tree]
InterPro	IPR000715. Glycosyl_transferase_4. IPR018481. Glycosyl_Trfase_4_cons-reg. IPR003524. PNAcMuramoyl-5peptid_Trfase. IPR018480. PNAcMuramoyl-5peptid_Trfase_CS. [Graphical view]
PANTHER	PTHR22926. Glyco_trans_4. 1 hit. PTHR22926:SF3. PNAcPpept_trans. 1 hit.
Pfam	PF00953. Glycos_transf_4. 1 hit. PF10555. MraY_sig1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00445. mraY. 1 hit.
PROSITE	PS01347. MRAY_1. 1 hit. PS01348. MRAY_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MRAY_ACAM1

Accession

Primary (citable) accession number: B0BZI7

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 29, 2008
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)