Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

B0BYA6 (UVRC_RICRO) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
UvrABC system protein C

Short name=Protein UvrC
Alternative name(s):
Excinuclease ABC subunit C
Gene names
Name:uvrC
Ordered Locus Names:RrIowa_1026
OrganismRickettsia rickettsii (strain Iowa) [Complete proteome] [HAMAP]
Taxonomic identifier452659 [NCBI]
Taxonomic lineageBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group

Protein attributes

Sequence length639 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision By similarity. HAMAP-Rule MF_00203

Subunit structure

Interacts with UvrB in an incision complex By similarity.

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00203.

Sequence similarities

Belongs to the UvrC family.

Contains 1 GIY-YIG domain.

Contains 1 UVR domain.

Ontologies

Keywords
   Biological processDNA damage
DNA excision
DNA repair
SOS response
   Cellular componentCytoplasm
   Molecular functionExcision nuclease
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processSOS response

Inferred from electronic annotation. Source: UniProtKB-HAMAP

nucleotide-excision repair

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

excinuclease repair complex

Inferred from electronic annotation. Source: InterPro

   Molecular_functionDNA binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

excinuclease ABC activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 639639UvrABC system protein C HAMAP-Rule MF_00203
PRO_1000077827

Regions

Domain20 – 9778GIY-YIG
Domain207 – 24236UVR

Sequences

Sequence LengthMass (Da)Tools
B0BYA6 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 711C4E8B237ECE2C

FASTA63973,408
        10         20         30         40         50         60 
MTLEITGSEL IKSKLIDAPE RSGVYRMFDV NKQVLYVGKA KNLKKRLTNY IKSNLDNKTL 

        70         80         90        100        110        120 
RMIANTCFLE YSITNSEVEA LLLEAQLIKK FQPKFNILLK DCKSFPFIKL RLEHDFPQLL 

       130        140        150        160        170        180 
KYRGKTLSDG KFFGPFASSV DVNTTLTELQ KIFKLRSCTD NYFNSRTRPC LQYEIKRCYA 

       190        200        210        220        230        240 
PCVGKINKED YRDLVTQVKD FLQGRTKELQ ENLSRKMEEL SSQMRFEEAA EIRDRIKALS 

       250        260        270        280        290        300 
YVQLKAGVSD VVKDADIIAI VEKNGHYCVE VFLYRAGQAC GNIPYFPTST ENSTKEEVLE 

       310        320        330        340        350        360 
YFLLQFYQKQ HVPAAIIINH EINDKENVIE AIKKINNILQ LNITVPNKGG KAKLVQNAEI 

       370        380        390        400        410        420 
NALFSLEQYL KKFAKNQEII FEIKELFGLS AIPERIEIYD NSHIQGKFAV GVMVVAGKVG 

       430        440        450        460        470        480 
FDKKEYRVFN VYAPSLVCHS RESGDPKRLM DSCFRGNGIK NCWGDIKGDD YEMLRQVLTR 

       490        500        510        520        530        540 
RLTRLRQEPH KLPSLMIIDG GKGHLGVVKE VMDKFEMNIP FVCMSKGVDR NAGFEQFHVI 

       550        560        570        580        590        600 
GKEVFTLDKN LPVMKYLQIL RDEAHNFAIK NHRLGRSRAI KISRLDDIEG VGETRKKALL 

       610        620        630 
HYFGSYKAVC DATIYELAKV NGINKLLAEM IFNVLHRKN 

« Hide

References

[1]"Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa."
Ellison D.W., Clark T.R., Sturdevant D.E., Virtaneva K., Porcella S.F., Hackstadt T.
Infect. Immun. 76:542-550(2008) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: Iowa.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
CP000766 Genomic DNA. Translation: ABY72832.1.
RefSeqYP_001650238.1. NC_010263.2.

3D structure databases

ProteinModelPortalB0BYA6.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING452659.RrIowa_1026.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaABY72832; ABY72832; RrIowa_1026.
GeneID5850246.
KEGGrrj:RrIowa_1026.
PATRIC17907947. VBIRicRic59104_1010.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0322.
HOGENOMHOG000279961.
KOK03703.
OMAQKLFPIR.
OrthoDBEOG6K13R9.
ProtClustDBPRK00558.

Enzyme and pathway databases

BioCycRRIC452659:GHSN-963-MONOMER.

Family and domain databases

Gene3D3.40.1440.10. 1 hit.
4.10.860.10. 1 hit.
HAMAPMF_00203. UvrC.
InterProIPR027299. GIY-YIG_dom.
IPR000305. GIY-YIG_SF.
IPR003583. Hlx-hairpin-Hlx_DNA-bd_motif.
IPR010994. RuvA_2-like.
IPR001943. UVR_dom.
IPR004791. UvrC.
IPR001162. UvrC_homol_region.
[Graphical view]
PfamPF01541. GIY-YIG. 1 hit.
PF02151. UVR. 1 hit.
PF08459. UvrC_HhH_N. 1 hit.
[Graphical view]
SMARTSM00465. GIYc. 1 hit.
SM00278. HhH1. 2 hits.
[Graphical view]
SUPFAMSSF46600. SSF46600. 1 hit.
SSF47781. SSF47781. 1 hit.
SSF82771. SSF82771. 1 hit.
TIGRFAMsTIGR00194. uvrC. 1 hit.
PROSITEPS50164. GIY_YIG. 1 hit.
PS50151. UVR. 1 hit.
PS50165. UVRC. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameUVRC_RICRO
AccessionPrimary (citable) accession number: B0BYA6
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families