B0BXB8 (GCH1_RICRO) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase 1
EC=3.5.4.16

Alternative name(s):
GTP cyclohydrolase I
Short name=GTP-CH-I

Gene names

Name:	folE
Ordered Locus Names:	RrIowa_0630

Organism

Rickettsia rickettsii (strain Iowa) [Complete proteome] [HAMAP]

Taxonomic identifier

452659 [NCBI]

Taxonomic lineage

cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia rickettsii

Protein attributes

Sequence length	189 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	GTP + H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate. HAMAP-Rule MF_00223
Pathway	Cofactor biosynthesis; 7,8-dihydroneopterin triphosphate biosynthesis; 7,8-dihydroneopterin triphosphate from GTP: step 1/1. HAMAP-Rule MF_00223
Subunit structure	Homopolymer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase I family.

Ontologies

Keywords
Biological process	One-carbon metabolism
Ligand	GTP-binding Metal-binding Nucleotide-binding Zinc
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	7,8-dihydroneopterin 3'-triphosphate biosynthetic process Inferred from electronic annotation. Source: UniProtKB-UniPathway one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP tetrahydrofolate biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	GTP binding Inferred from electronic annotation. Source: UniProtKB-KW GTP cyclohydrolase I activity Inferred from electronic annotation. Source: HAMAP zinc ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 189	189	GTP cyclohydrolase 1 HAMAP-Rule MF_00223		PRO_1000078147
Sites
	Metal binding	79	1	Zinc By similarity
	Metal binding	82	1	Zinc By similarity
	Metal binding	150	1	Zinc By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0BXB8 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 217A5C090D4F02F3	FASTA	189	21,584
	10 20 30 40 50 60 MSKPTREEAK EAVRTLLKFI GEDPSREGLL KTPDRVINSY AEIFSGYGKD VAEILNTKFY 70 80 90 100 110 120 ETCNFRDFIL LNIKFTSFCE HHILPFNGTV DIAYVPDNCI VGISKLARIV NIFARRLQIQ 130 140 150 160 170 180 EKMTVQIAES VQENLKPLGV AVKISAVHSC MSMRGVMQDN SVMNTMHYTG IFAEQQKYRH EFLNLTAKR

References

[1]

"Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa." Ellison D.W., Clark T.R., Sturdevant D.E., Virtaneva K., Porcella S.F., Hackstadt T. Infect. Immun. 76:542-550(2008) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Iowa.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000766 Genomic DNA. Translation: ABY72494.1.
RefSeq	YP_001649900.1. NC_010263.2.
3D structure databases
ProteinModelPortal	B0BXB8.
ModBase	Search...
Protein-protein interaction databases
STRING	452659.RrIowa_0630.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	ABY72494; ABY72494; RrIowa_0630.
GeneID	5850010.
KEGG	rrj:RrIowa_0630.
PATRIC	17907150. VBIRicRic59104_0621.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG0302.
HOGENOM	HOG000221222.
KO	K01495.
OMA	VEIYGRR.
ProtClustDB	PRK09347.
Enzyme and pathway databases
BioCyc	RRIC452659:GHSN-599-MONOMER.
UniPathway	UPA00848; UER00151.
Family and domain databases
HAMAP	MF_00223. FolE.
InterPro	IPR001474. GTP_CycHdrlase_I. IPR020602. GTP_CycHdrlase_I/CN_OxRdtase. IPR018234. GTP_CycHdrlase_I_CS. [Graphical view]
PANTHER	PTHR11109. PTHR11109. 1 hit.
Pfam	PF01227. GTP_cyclohydroI. 1 hit. [Graphical view]
TIGRFAMs	TIGR00063. folE. 1 hit.
PROSITE	PS00859. GTP_CYCLOHYDROL_1_1. 1 hit. PS00860. GTP_CYCLOHYDROL_1_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GCH1_RICRO

Accession

Primary (citable) accession number: B0BXB8

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 41 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program