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B0BWB9

- B0BWB9_RICRO

UniProt

B0BWB9 - B0BWB9_RICRO

Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Rickettsia rickettsii (strain Iowa)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi
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    • History
      Entry version 57 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
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    • Comment

    Functioni

    Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotationSAAS annotation

    Catalytic activityi

    (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotationSAAS annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei180 – 1801Proton donor/acceptorUniRule annotation
    Binding sitei181 – 1811SubstrateUniRule annotation
    Active sitei184 – 1841Proton donorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi54 – 596NAD(P)UniRule annotation
    Nucleotide bindingi124 – 1263NAD(P)UniRule annotation
    Nucleotide bindingi148 – 1514NAD(P)UniRule annotation

    GO - Molecular functioni

    1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
    2. NAD binding Source: UniProtKB-HAMAP
    3. NADPH binding Source: InterPro
    4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

    GO - Biological processi

    1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
    2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    OxidoreductaseUniRule annotationSAAS annotationImported

    Keywords - Biological processi

    Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

    Keywords - Ligandi

    NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

    Enzyme and pathway databases

    BioCyciRRIC452659:GHSN-224-MONOMER.
    UniPathwayiUPA00034; UER00018.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
    Short name:
    HTPA reductaseUniRule annotation
    Gene namesi
    Name:dapBUniRule annotation
    Ordered Locus Names:RrIowa_0233Imported
    OrganismiRickettsia rickettsii (strain Iowa)Imported
    Taxonomic identifieri452659 [NCBI]
    Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
    ProteomesiUP000000796: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotationSAAS annotation

    Interactioni

    Subunit structurei

    Homotetramer.UniRule annotation

    Protein-protein interaction databases

    STRINGi452659.RrIowa_0233.

    Structurei

    3D structure databases

    ProteinModelPortaliB0BWB9.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni190 – 1912Substrate bindingUniRule annotation

    Sequence similaritiesi

    Belongs to the DapB family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG0289.
    HOGENOMiHOG000227155.
    KOiK00215.
    OMAiAHHRFKV.
    OrthoDBiEOG6SV5DS.

    Family and domain databases

    Gene3Di3.40.50.720. 1 hit.
    HAMAPiMF_00102. DapB.
    InterProiIPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view]
    PANTHERiPTHR20836. PTHR20836. 1 hit.
    PfamiPF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view]
    PIRSFiPIRSF000161. DHPR. 1 hit.
    TIGRFAMsiTIGR00036. dapB. 1 hit.
    PROSITEiPS01298. DAPB. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    B0BWB9-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASYNKICGS NYIKYTLRSK DFRRLALVQI KLRLLTVHLL GVYIANMLNI    50
    GLSGSTGKMG ETILERIDKF KDCKIAAKFN STNNLDDLDN FCKNSDVIID 100
    FSTPEILEKL INYALKHNTK LVIGTTGLQP QHFKLLEKAA QTLPVLYSAN 150
    MSIGANLLSY LAKEVTKILD DYDVEILETH HRNKKDSPSG TAVMLAETIA 200
    SKKGLNITFN RGNRLRSEKE IGISSLRGGN VHGIHEISFL GDDEIITLKH 250
    EALNKNSFSI GAIKAAIWLQ DKPSALYSMQ DIYKI 285
    Length:285
    Mass (Da):31,820
    Last modified:February 26, 2008 - v1
    Checksum:i549827E6CE4F0EA0
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000766 Genomic DNA. Translation: ABY72145.1.
    RefSeqiYP_001649551.1. NC_010263.2.

    Genome annotation databases

    EnsemblBacteriaiABY72145; ABY72145; RrIowa_0233.
    GeneIDi5849763.
    KEGGirrj:RrIowa_0233.
    PATRICi17906348. VBIRicRic59104_0227.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    CP000766 Genomic DNA. Translation: ABY72145.1 .
    RefSeqi YP_001649551.1. NC_010263.2.

    3D structure databases

    ProteinModelPortali B0BWB9.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 452659.RrIowa_0233.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai ABY72145 ; ABY72145 ; RrIowa_0233 .
    GeneIDi 5849763.
    KEGGi rrj:RrIowa_0233.
    PATRICi 17906348. VBIRicRic59104_0227.

    Phylogenomic databases

    eggNOGi COG0289.
    HOGENOMi HOG000227155.
    KOi K00215.
    OMAi AHHRFKV.
    OrthoDBi EOG6SV5DS.

    Enzyme and pathway databases

    UniPathwayi UPA00034 ; UER00018 .
    BioCyci RRIC452659:GHSN-224-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.720. 1 hit.
    HAMAPi MF_00102. DapB.
    InterProi IPR022663. DapB_C.
    IPR000846. DapB_N.
    IPR022664. DapB_N_CS.
    IPR011770. Dihydrodipicolinate_Rdtase.
    IPR023940. Dihydrodipicolinate_Rdtase_bac.
    IPR016040. NAD(P)-bd_dom.
    [Graphical view ]
    PANTHERi PTHR20836. PTHR20836. 1 hit.
    Pfami PF05173. DapB_C. 1 hit.
    PF01113. DapB_N. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF000161. DHPR. 1 hit.
    TIGRFAMsi TIGR00036. dapB. 1 hit.
    PROSITEi PS01298. DAPB. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa."
      Ellison D.W., Clark T.R., Sturdevant D.E., Virtaneva K., Porcella S.F., Hackstadt T.
      Infect. Immun. 76:542-550(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: IowaImported.

    Entry informationi

    Entry nameiB0BWB9_RICRO
    AccessioniPrimary (citable) accession number: B0BWB9
    Entry historyi
    Integrated into UniProtKB/TrEMBL: February 26, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 57 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Caution

    Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.UniRule annotation

    Keywords - Technical termi

    Complete proteomeImported

    External Data

    Dasty 3