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B0BWB9

- B0BWB9_RICRO

UniProt

B0BWB9 - B0BWB9_RICRO

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Protein

4-hydroxy-tetrahydrodipicolinate reductase

Gene

dapB

Organism
Rickettsia rickettsii (strain Iowa)
Status
Unreviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.UniRule annotationSAAS annotation

Catalytic activityi

(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + NAD(P)+ + H2O = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + NAD(P)H.UniRule annotationSAAS annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei180 – 1801Proton donor/acceptorUniRule annotation
Binding sitei181 – 1811SubstrateUniRule annotation
Active sitei184 – 1841Proton donorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi54 – 596NAD(P)UniRule annotation
Nucleotide bindingi124 – 1263NAD(P)UniRule annotation
Nucleotide bindingi148 – 1514NAD(P)UniRule annotation

GO - Molecular functioni

  1. 4-hydroxy-tetrahydrodipicolinate reductase Source: UniProtKB-EC
  2. NAD binding Source: UniProtKB-HAMAP
  3. NADPH binding Source: InterPro
  4. oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor Source: UniProtKB-HAMAP

GO - Biological processi

  1. diaminopimelate biosynthetic process Source: UniProtKB-HAMAP
  2. lysine biosynthetic process via diaminopimelate Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

OxidoreductaseUniRule annotationSAAS annotation

Keywords - Biological processi

Amino-acid biosynthesis, Diaminopimelate biosynthesisUniRule annotationSAAS annotation, Lysine biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

NADUniRule annotationSAAS annotation, NADPUniRule annotationSAAS annotation

Enzyme and pathway databases

BioCyciRRIC452659:GHSN-224-MONOMER.
UniPathwayiUPA00034; UER00018.

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxy-tetrahydrodipicolinate reductaseUniRule annotation (EC:1.17.1.8UniRule annotation)
Short name:
HTPA reductaseUniRule annotation
Gene namesi
Name:dapBUniRule annotation
Ordered Locus Names:RrIowa_0233Imported
OrganismiRickettsia rickettsii (strain Iowa)Imported
Taxonomic identifieri452659 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000796: Chromosome

Subcellular locationi

Cytoplasm UniRule annotationSAAS annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotationSAAS annotation

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi452659.RrIowa_0233.

Structurei

3D structure databases

ProteinModelPortaliB0BWB9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni190 – 1912Substrate bindingUniRule annotation

Sequence similaritiesi

Belongs to the DapB family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0289.
HOGENOMiHOG000227155.
KOiK00215.
OMAiAHHRFKV.
OrthoDBiEOG6SV5DS.

Family and domain databases

Gene3Di3.40.50.720. 1 hit.
HAMAPiMF_00102. DapB.
InterProiIPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view]
PANTHERiPTHR20836. PTHR20836. 1 hit.
PfamiPF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view]
PIRSFiPIRSF000161. DHPR. 1 hit.
TIGRFAMsiTIGR00036. dapB. 1 hit.
PROSITEiPS01298. DAPB. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0BWB9 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASYNKICGS NYIKYTLRSK DFRRLALVQI KLRLLTVHLL GVYIANMLNI
60 70 80 90 100
GLSGSTGKMG ETILERIDKF KDCKIAAKFN STNNLDDLDN FCKNSDVIID
110 120 130 140 150
FSTPEILEKL INYALKHNTK LVIGTTGLQP QHFKLLEKAA QTLPVLYSAN
160 170 180 190 200
MSIGANLLSY LAKEVTKILD DYDVEILETH HRNKKDSPSG TAVMLAETIA
210 220 230 240 250
SKKGLNITFN RGNRLRSEKE IGISSLRGGN VHGIHEISFL GDDEIITLKH
260 270 280
EALNKNSFSI GAIKAAIWLQ DKPSALYSMQ DIYKI
Length:285
Mass (Da):31,820
Last modified:February 26, 2008 - v1
Checksum:i549827E6CE4F0EA0
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000766 Genomic DNA. Translation: ABY72145.1.
RefSeqiYP_001649551.1. NC_010263.2.

Genome annotation databases

EnsemblBacteriaiABY72145; ABY72145; RrIowa_0233.
GeneIDi5849763.
KEGGirrj:RrIowa_0233.
PATRICi17906348. VBIRicRic59104_0227.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000766 Genomic DNA. Translation: ABY72145.1 .
RefSeqi YP_001649551.1. NC_010263.2.

3D structure databases

ProteinModelPortali B0BWB9.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452659.RrIowa_0233.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY72145 ; ABY72145 ; RrIowa_0233 .
GeneIDi 5849763.
KEGGi rrj:RrIowa_0233.
PATRICi 17906348. VBIRicRic59104_0227.

Phylogenomic databases

eggNOGi COG0289.
HOGENOMi HOG000227155.
KOi K00215.
OMAi AHHRFKV.
OrthoDBi EOG6SV5DS.

Enzyme and pathway databases

UniPathwayi UPA00034 ; UER00018 .
BioCyci RRIC452659:GHSN-224-MONOMER.

Family and domain databases

Gene3Di 3.40.50.720. 1 hit.
HAMAPi MF_00102. DapB.
InterProi IPR022663. DapB_C.
IPR000846. DapB_N.
IPR022664. DapB_N_CS.
IPR011770. Dihydrodipicolinate_Rdtase.
IPR023940. Dihydrodipicolinate_Rdtase_bac.
IPR016040. NAD(P)-bd_dom.
[Graphical view ]
PANTHERi PTHR20836. PTHR20836. 1 hit.
Pfami PF05173. DapB_C. 1 hit.
PF01113. DapB_N. 1 hit.
[Graphical view ]
PIRSFi PIRSF000161. DHPR. 1 hit.
TIGRFAMsi TIGR00036. dapB. 1 hit.
PROSITEi PS01298. DAPB. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa."
    Ellison D.W., Clark T.R., Sturdevant D.E., Virtaneva K., Porcella S.F., Hackstadt T.
    Infect. Immun. 76:542-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: IowaImported.

Entry informationi

Entry nameiB0BWB9_RICRO
AccessioniPrimary (citable) accession number: B0BWB9
Entry historyi
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Caution

Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction.UniRule annotation

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3