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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Rickettsia rickettsii (strain Iowa)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRRIC452659:GHSN-117-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligaseUniRule annotation (EC:6.1.1.19UniRule annotation)
Alternative name(s):
Arginyl-tRNA synthetaseUniRule annotation
Short name:
ArgRSUniRule annotation
Gene namesi
Name:argSUniRule annotation
Ordered Locus Names:RrIowa_0123
OrganismiRickettsia rickettsii (strain Iowa)
Taxonomic identifieri452659 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000796 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 576576Arginine--tRNA ligasePRO_1000076226Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi452659.RrIowa_0123.

Structurei

3D structure databases

ProteinModelPortaliB0BW17.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi126 – 13611"HIGH" regionAdd
BLAST

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OMAiLDTHLEF.
OrthoDBiEOG6JB13C.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0BW17-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIFNQLKQD IIVASKQLYN NQAIANTATI DIPKDSFNGD LSSNVAMIIA
60 70 80 90 100
AKESIAPREV ALKFKEVLIT LPYIASIEIA GPGFINFTIK ADSWQASIKD
110 120 130 140 150
ILQHEEKFFE IDIDKSRNIN IEYVSANPTG PMHIGHARGA VYGDVLARIL
160 170 180 190 200
QKVSYSVTKE YYVNDAGSQI NDLVSTVLLR YKEALGEQIT IPAGLYPGEY
210 220 230 240 250
LIPLGQILAK EYGNKLLTMN YDERFKIIKS FAVEKMLDLN RKDLADLGIK
260 270 280 290 300
HDIFFSEQSL HDKGEIEETV KLLESMGLIY EGTLPAPKGK IHEEWDNRVQ
310 320 330 340 350
KLFKSTKYGD SQDRPIEKAD GSWSYFASDL AYAKDKIERG ANHLIYVLGA
360 370 380 390 400
DHSGYVKRIE AIVKALGKEQ VKVDVKICQL VNFVENGVPV KMSKRLGSFA
410 420 430 440 450
SVQDVNNEVG KDIIRFMMLT RQNDKPLDFD LVKVKEQSRE NPIFYVQYAH
460 470 480 490 500
VRTISILSKA RELMPESYNN FESGKYDLSL LSSEEEIEII KLLVSWTKTL
510 520 530 540 550
EASAKYFEPH RIAFYLINLA SKFHSMWNFG KENSEYRFVI ESNKELTLAR
560 570
LALASAIQKV IASGLEVIGV EPMNKM
Length:576
Mass (Da):65,142
Last modified:February 26, 2008 - v1
Checksum:iB4BD631836470C02
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000766 Genomic DNA. Translation: ABY72043.1.
RefSeqiWP_012150320.1. NC_010263.2.

Genome annotation databases

EnsemblBacteriaiABY72043; ABY72043; RrIowa_0123.
KEGGirrj:RrIowa_0123.
PATRICi17906138. VBIRicRic59104_0125.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000766 Genomic DNA. Translation: ABY72043.1.
RefSeqiWP_012150320.1. NC_010263.2.

3D structure databases

ProteinModelPortaliB0BW17.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi452659.RrIowa_0123.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY72043; ABY72043; RrIowa_0123.
KEGGirrj:RrIowa_0123.
PATRICi17906138. VBIRicRic59104_0125.

Phylogenomic databases

eggNOGiCOG0018.
HOGENOMiHOG000247214.
KOiK01887.
OMAiLDTHLEF.
OrthoDBiEOG6JB13C.

Enzyme and pathway databases

BioCyciRRIC452659:GHSN-117-MONOMER.

Family and domain databases

Gene3Di1.10.730.10. 1 hit.
3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth.
InterProiIPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_1a_anticodon-bd.
[Graphical view]
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiPF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
[Graphical view]
PRINTSiPR01038. TRNASYNTHARG.
SMARTiSM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
[Graphical view]
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa."
    Ellison D.W., Clark T.R., Sturdevant D.E., Virtaneva K., Porcella S.F., Hackstadt T.
    Infect. Immun. 76:542-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Iowa.

Entry informationi

Entry nameiSYR_RICRO
AccessioniPrimary (citable) accession number: B0BW17
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: May 27, 2015
This is version 47 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.