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Protein

Peptide deformylase

Gene

def

Organism
Rickettsia rickettsii (strain Iowa)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.UniRule annotation

Catalytic activityi

Formyl-L-methionyl peptide + H2O = formate + methionyl peptide.UniRule annotationSAAS annotation

Cofactori

Fe2+UniRule annotationNote: Binds 1 Fe2+ ion.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi142IronUniRule annotation1
Metal bindingi184IronUniRule annotation1
Active sitei185UniRule annotation1
Metal bindingi188IronUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolaseUniRule annotationSAAS annotationImported
Biological processProtein biosynthesisUniRule annotationSAAS annotation
LigandIronUniRule annotation, Metal-bindingUniRule annotationSAAS annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Peptide deformylaseUniRule annotationSAAS annotation (EC:3.5.1.88UniRule annotationSAAS annotation)
Short name:
PDFUniRule annotation
Alternative name(s):
Polypeptide deformylaseUniRule annotation
Gene namesi
Name:defUniRule annotation
Ordered Locus Names:RrIowa_0105Imported
OrganismiRickettsia rickettsii (strain Iowa)Imported
Taxonomic identifieri452659 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
Proteomesi
  • UP000000796 Componenti: Chromosome

Structurei

3D structure databases

ProteinModelPortaliB0BVZ9.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the polypeptide deformylase family.UniRule annotationSAAS annotation

Phylogenomic databases

HOGENOMiHOG000010827.
KOiK01462.
OMAiHREYSSV.
OrthoDBiPOG091H02B0.

Family and domain databases

CDDicd00487. Pep_deformylase. 1 hit.
Gene3Di3.90.45.10. 1 hit.
HAMAPiMF_00163. Pep_deformylase. 1 hit.
InterProiView protein in InterPro
IPR023635. Peptide_deformylase.
IPR036821. Peptide_deformylase_sf.
PANTHERiPTHR10458. PTHR10458. 1 hit.
PfamiView protein in Pfam
PF01327. Pep_deformylase. 1 hit.
PIRSFiPIRSF004749. Pep_def. 1 hit.
PRINTSiPR01576. PDEFORMYLASE.
SUPFAMiSSF56420. SSF56420. 1 hit.

Sequencei

Sequence statusi: Complete.

B0BVZ9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSKLKTALLL TAIIFITGCK SNMKNENNIS LPQYVTLNIQ TLNSSEDKTI
60 70 80 90 100
RIKAKTLNFP LSSEDLRDIS ILEKKYDQEE NCAGLAAPQI GISKCIIIFA
110 120 130 140 150
VHEDAELKKW HPDLKDTMPK TIWINPSYKP IGIDKHEDYE GCFSVENATG
160 170 180 190 200
PVARFKKIHY HAYDINGNQI QGIAEGFLAR VIQHEIDHLN GKVFLDYVAP
210 220
KKIMTKEEYL EMRKKAMEQE NIKS
Length:224
Mass (Da):25,540
Last modified:February 26, 2008 - v1
Checksum:i74ED5CB61C16237F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000766 Genomic DNA. Translation: ABY72025.1.
RefSeqiWP_010976764.1. NC_010263.3.

Genome annotation databases

EnsemblBacteriaiABY72025; ABY72025; RrIowa_0105.
GeneIDi928534.
KEGGirrj:RrIowa_0105.

Similar proteinsi

Entry informationi

Entry nameiB0BVZ9_RICRO
AccessioniPrimary (citable) accession number: B0BVZ9
Entry historyiIntegrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 25, 2017
This is version 68 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported