ftsZ

Functionⁱ

Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.UniRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	142	GTPUniRule annotation	1
Binding siteⁱ	146	GTPUniRule annotation	1
Binding siteⁱ	190	GTPUniRule annotation	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	24 – 28	GTPUniRule annotation		5
Nucleotide bindingⁱ	111 – 113	GTPUniRule annotation		3

GO - Molecular functionⁱ

GTPase activity Source: UniProtKB-HAMAP
GTP binding Source: UniProtKB-HAMAP

Complete GO annotation...

GO - Biological processⁱ

cell septum assembly Source: UniProtKB-HAMAP
FtsZ-dependent cytokinesis Source: UniProtKB-HAMAP
protein polymerization Source: UniProtKB-HAMAP

Complete GO annotation...

Keywordsⁱ

Biological process	Cell cycle, Cell division, SeptationUniRule annotation
Ligand	GTP-bindingUniRule annotation, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cell division protein FtsZUniRule annotation
Gene namesⁱ	Name:ftsZUniRule annotationImported Ordered Locus Names:RrIowa_1207Imported
Organismⁱ	Rickettsia rickettsii (strain Iowa)Imported
Taxonomic identifierⁱ	452659 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Bacteria › Proteobacteria › Alphaproteobacteria › Rickettsiales › Rickettsiaceae › Rickettsieae › Rickettsia › spotted fever group › Rickettsia rickettsii
Proteomesⁱ	UP000000796 Componentⁱ: Chromosome

Subcellular locationⁱ

GO - Cellular componentⁱ

cell division site Source: UniProtKB-HAMAP
cytoplasm Source: UniProtKB-HAMAP

Complete GO annotation...

Keywords - Cellular componentⁱ

CytoplasmUniRule annotation

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	B0BUR8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	16 – 208	TubulinInterPro annotationAdd BLAST		193
Domainⁱ	210 – 329	Tubulin_CInterPro annotationAdd BLAST		120

Sequence similaritiesⁱ

Belongs to the FtsZ family.UniRule annotation

Phylogenomic databases

HOGENOMⁱ	HOG000049094.
KEGG Orthology (KO) More...KOⁱ	K03531.
OMAⁱ	MRAVKGI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02KK.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02201. FtsZ_type1. 1 hit.
Gene3Dⁱ	3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit.
HAMAPⁱ	MF_00909. FtsZ. 1 hit.
InterProⁱ	View protein in InterPro IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR003008. Tubulin_FtsZ_GTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit.
PRINTSⁱ	PR00423. CELLDVISFTSZ.
SMARTⁱ	View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit.
SUPFAMⁱ	SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit.
TIGRFAMsⁱ	TIGR00065. ftsZ. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit.

Sequenceⁱ

Sequence statusⁱ: Complete.

B0BUR8-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MVLNIKAPEN IVLKPTITVF GVGGAGSNAV NNMISANLQG ANFVVANTDA 
        60         70         80         90        100
QSLEHSLCTN KIQLGVSTTR GLGAGASPEV GALAAQESES EIRNYLENSN 
       110        120        130        140        150
MVFITAGMGG GTGTGSAPVI ARIAKELGIL TVGVATKPFH FEGGHRMKTA 
       160        170        180        190        200
DKGLIELQQF VDTLIVIPNQ NLFRIANEQT TFADAFKMAD DVLHAGVRGV 
       210        220        230        240        250
TDLMIMPGLI NLDFADIKAV MSEMGKAMMG TGEASGEDRA IKAAESAISN 
       260        270        280        290        300
PLLDHSSMCG ARGVLINITG GSDMTLFEVD NAANRIREEV DNLDANIIFG 
       310        320        330        340        350
STFNPELKGM IRVSVVATGI DADKVPTYKP AIAETTNIVP EETYNKAIAQ 
       360        370        380        390        400
PTQIEEMPDF NSYSTKNIEI TDSPINQNLI GNEKELGLHA NTFNKSEDDS 
       410        420        430        440        450
PKPSFLGKIW GSLRASNNQT LERKNVVVST LDQDNKESDI HDIPAFLRKQ 

RD

Length:452

Mass (Da):48,338

Last modified:February 26, 2008 - v1

Checksum:ⁱ5A63209D8BA3FE6B

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000766 Genomic DNA. Translation: ABY72978.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012262534.1. NC_010263.3.

Genome annotation databases

EnsemblBacteriaⁱ	ABY72978; ABY72978; RrIowa_1207.
KEGGⁱ	rrj:RrIowa_1207.

Similar proteinsⁱ

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:

100%	UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%	UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%	UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	CP000766 Genomic DNA. Translation: ABY72978.1.
NCBI Reference Sequences More...RefSeqⁱ	WP_012262534.1. NC_010263.3.

3D structure databases

ProteinModelPortalⁱ	B0BUR8.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

EnsemblBacteriaⁱ	ABY72978; ABY72978; RrIowa_1207.
KEGGⁱ	rrj:RrIowa_1207.

Phylogenomic databases

HOGENOMⁱ	HOG000049094.
KEGG Orthology (KO) More...KOⁱ	K03531.
OMAⁱ	MRAVKGI.
Database of Orthologous Groups More...OrthoDBⁱ	POG091H02KK.

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd02201. FtsZ_type1. 1 hit.
Gene3Dⁱ	3.30.1330.20. 1 hit. 3.40.50.1440. 1 hit.
HAMAPⁱ	MF_00909. FtsZ. 1 hit.
InterProⁱ	View protein in InterPro IPR000158. Cell_div_FtsZ. IPR020805. Cell_div_FtsZ_CS. IPR024757. FtsZ_C. IPR008280. Tub_FtsZ_C. IPR018316. Tubulin/FtsZ_2-layer-sand-dom. IPR003008. Tubulin_FtsZ_GTPase.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF12327. FtsZ_C. 1 hit. PF00091. Tubulin. 1 hit.
PRINTSⁱ	PR00423. CELLDVISFTSZ.
SMARTⁱ	View protein in SMART SM00864. Tubulin. 1 hit. SM00865. Tubulin_C. 1 hit.
SUPFAMⁱ	SSF52490. SSF52490. 1 hit. SSF55307. SSF55307. 1 hit.
TIGRFAMsⁱ	TIGR00065. ftsZ. 1 hit.
PROSITEⁱ	View protein in PROSITE PS01134. FTSZ_1. 1 hit. PS01135. FTSZ_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	B0BUR8_RICRO
Accessionⁱ	B0BUR8Primary (citable) accession number: B0BUR8
Entry historyⁱ	Integrated into UniProtKB/TrEMBL:	February 26, 2008
	Last sequence update:	February 26, 2008
	Last modified:	June 7, 2017
	This is version 72 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Unreviewed (UniProtKB/TrEMBL)

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteomeImported

UniProtKB - B0BUR8 (B0BUR8_RICRO)

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Cell division protein FtsZ

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Functionⁱ

Sites

Regions

GO - Molecular functionⁱ

GO - Biological processⁱ

Keywordsⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Keywords - Cellular componentⁱ

Structureⁱ

3D structure databases

Family & Domainsⁱ

Domains and Repeats

Sequence similaritiesⁱ

Phylogenomic databases

Family and domain databases

Sequenceⁱ

Sequence databases

Genome annotation databases

Similar proteinsⁱ

Cross-referencesⁱ

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - B0BUR8 (B0BUR8_RICRO)

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Cell division protein FtsZ

ftsZ

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componenti

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protocols and materials databases

Genome annotation databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

GO - Cellular componentⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequenceⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ