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B0BUL7

- SYE2_RICRO

UniProt

B0BUL7 - SYE2_RICRO

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Protein

Glutamate--tRNA ligase 2

Gene

gltX2

Organism
Rickettsia rickettsii (strain Iowa)
Status
Reviewed - Annotation score: 3 out of 5- Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei243 – 2431ATPUniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. glutamate-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. glutamyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciRRIC452659:GHSN-1068-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligase 2UniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetase 2UniRule annotation
Short name:
GluRS 2UniRule annotation
Gene namesi
Name:gltX2UniRule annotation
Ordered Locus Names:RrIowa_1141
OrganismiRickettsia rickettsii (strain Iowa)
Taxonomic identifieri452659 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaAlphaproteobacteriaRickettsialesRickettsiaceaeRickettsieaeRickettsiaspotted fever group
ProteomesiUP000000796: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 513513Glutamate--tRNA ligase 2PRO_0000367761Add
BLAST

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi452659.RrIowa_1141.

Structurei

3D structure databases

ProteinModelPortaliB0BUL7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi11 – 2111"HIGH" regionAdd
BLAST
Motifi240 – 2445"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG0008.
HOGENOMiHOG000252722.
KOiK01885.
OMAiHCLRASI.
OrthoDBiEOG6DRPF7.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00022_B. Glu_tRNA_synth_B.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR005728. Rickett_RPE.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PANTHERiPTHR10119. PTHR10119. 1 hit.
PfamiPF00749. tRNA-synt_1c. 1 hit.
[Graphical view]
PRINTSiPR00987. TRNASYNTHGLU.
SUPFAMiSSF48163. SSF48163. 2 hits.
TIGRFAMsiTIGR00464. gltX_bact. 1 hit.
TIGR01045. RPE1. 1 hit.

Sequencei

Sequence statusi: Complete.

B0BUL7 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNNNVITRFA PSPTGFLHIG SARTALFNYL FARHHNGKFL LRIEDTDKER
60 70 80 90 100
STKEAVEAIF SGLKWLGLDW NGEVIFQSKR NNLYKEAALK LLQNGKAYYC
110 120 130 140 150
FTRQEEIERQ RQQALENKQH FIFNSEWRDK DPSIYPTDIK PVIRLKTPRE
160 170 180 190 200
GSITIHDTLQ GEVVIENSHI DDMVLLRADG TATYMLAVVV DDHDMGITHI
210 220 230 240 250
IRGNDHLTNA ARQLAIYQAF GYAVPSMTHI PLIHGADGAK LSKRHGALGI
260 270 280 290 300
EAYKDMGYLP ESLCNYLLRL GWSHGDDEII SMTQAIDWFN LDSLGKSPAK
310 320 330 340 350
LDFAKMNSLN SHYLRMLDND SLTSKIVEIL EQNYNKLLQK LAYREEFGGN
360 370 380 390 400
TERSTAAYID IREDASTGLT YKLPLAVELP KKFKVSEQEI GYIKQAMPSL
410 420 430 440 450
LVRSETLLEL TRLAQIYLVD SPIIYSQDSK EIIENCDKNL IKQIIENLSE
460 470 480 490 500
LEQFDKESVQ NKFKEIAAAN DLKLNDIMKP VRALITGMTA SPSVFEIAEI
510
LGKENILKRL KII
Length:513
Mass (Da):58,370
Last modified:February 26, 2008 - v1
Checksum:iB866244FE176235E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000766 Genomic DNA. Translation: ABY72927.1.
RefSeqiYP_001650333.1. NC_010263.2.

Genome annotation databases

EnsemblBacteriaiABY72927; ABY72927; RrIowa_1141.
GeneIDi5849154.
KEGGirrj:RrIowa_1141.
PATRICi17908189. VBIRicRic59104_1127.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
CP000766 Genomic DNA. Translation: ABY72927.1 .
RefSeqi YP_001650333.1. NC_010263.2.

3D structure databases

ProteinModelPortali B0BUL7.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 452659.RrIowa_1141.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai ABY72927 ; ABY72927 ; RrIowa_1141 .
GeneIDi 5849154.
KEGGi rrj:RrIowa_1141.
PATRICi 17908189. VBIRicRic59104_1127.

Phylogenomic databases

eggNOGi COG0008.
HOGENOMi HOG000252722.
KOi K01885.
OMAi HCLRASI.
OrthoDBi EOG6DRPF7.

Enzyme and pathway databases

BioCyci RRIC452659:GHSN-1068-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
1.10.1160.10. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00022_B. Glu_tRNA_synth_B.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR004527. Glu-tRNA-ligase_bac/mito.
IPR000924. Glu/Gln-tRNA-synth.
IPR020061. Glu/Gln-tRNA-synth_Ib_a-bdl.
IPR020058. Glu/Gln-tRNA-synth_Ib_cat-dom.
IPR005728. Rickett_RPE.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
PANTHERi PTHR10119. PTHR10119. 1 hit.
Pfami PF00749. tRNA-synt_1c. 1 hit.
[Graphical view ]
PRINTSi PR00987. TRNASYNTHGLU.
SUPFAMi SSF48163. SSF48163. 2 hits.
TIGRFAMsi TIGR00464. gltX_bact. 1 hit.
TIGR01045. RPE1. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "Genomic comparison of virulent Rickettsia rickettsii Sheila Smith and avirulent Rickettsia rickettsii Iowa."
    Ellison D.W., Clark T.R., Sturdevant D.E., Virtaneva K., Porcella S.F., Hackstadt T.
    Infect. Immun. 76:542-550(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: Iowa.

Entry informationi

Entry nameiSYE2_RICRO
AccessioniPrimary (citable) accession number: B0BUL7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 26, 2008
Last modified: October 29, 2014
This is version 48 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3