B0BTY3 (MUTL_ACTPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
DNA mismatch repair protein mutL

Gene names

Name:	mutL
Ordered Locus Names:	APJL_2005

Organism

Actinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP]

Taxonomic identifier

434271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	622 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a "molecular matchmaker", a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex By similarity. HAMAP MF_00149
Sequence similarities	Belongs to the DNA mismatch repair mutL/hexB family.

Ontologies

Keywords
Biological process	DNA damage DNA repair
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	mismatch repair Inferred from electronic annotation. Source: InterPro
Molecular function	ATP binding Inferred from electronic annotation. Source: InterPro mismatched DNA binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 622	622	DNA mismatch repair protein mutL HAMAP MF_00149		PRO_1000096622

Sequences

	Sequence		Length	Mass (Da)
	B0BTY3 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 2DCA6752D47D42E3	FASTA	622	69,426
	10 20 30 40 50 60 MNKPLIHILP PQLANQIAAG EVVERPASVV KELVENSLDA GANQIQIDIE KGGAQLIRIR 70 80 90 100 110 120 DNGCGIGKQD LALALARHAT SKISSLEDLE MILSLGFRGE ALASISSVSR LTLTSRPAGQ 130 140 150 160 170 180 AEAWQAYAQG REMEVEIQPA SHPVGTTIEV ANLFFNTPAR RKFLRTDKTE FTHIDEVVRR 190 200 210 220 230 240 IALAKPNIGF TLTHNGKTVR QYRKVQDNSV EQQQRRVAAI CGDDFIQNAI HIDWQHGDLH 250 260 270 280 290 300 LHGWIGLPNI SRPQNDLCYS YVNGRMMRDK TINHAIRQAY EATDMPEGNY PAFVVFLDID 310 320 330 340 350 360 PSQVDVNVHP AKHEVRFHQG RLVHDFILQG VQTALQGQAE IDLTHQVNEP LPSYQRNTNR 370 380 390 400 410 420 MAAGGNSFLA SQQAVEFTEN FAKPTASHMP NYSPRTSGVS KSAQKWYGEL VSQPQNQSDN 430 440 450 460 470 480 IQDLIEPKAN FAPVIFAQEI DEAEPKPTQV VSAAIGHWQP LAIVQNQALL LKAEQQFYLL 490 500 510 520 530 540 SLEKLARLRF QTQLTKGESQ ALLIPLNLSL DEQQTQRWQT LKTPLAELGF AISEKTWQGQ 550 560 570 580 590 600 IRLSVTQVPR LLREQNLQQI LLSLFASQAV DLTEFFAKFA PIPTAYSLAE AVNWLAETEQ 610 620 TAKSELEKLK VAVDFSAFLA RC

References

[1]

"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China." Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H. PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JL03.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000687 Genomic DNA. Translation: ABY70550.1.
RefSeq	YP_001652994.1. NC_010278.1.
3D structure databases
ProteinModelPortal	B0BTY3.
SMR	B0BTY3. Positions 6-336.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BTY3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5851001.
GenomeReviews	Gene locus APJL_2005 in contig CP000687_GR.
KEGG	apj:APJL_2005.
PATRIC	20753360. VBIActPle136345_1997.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG520262.
OMA	EVANLFF.
ProtClustDB	PRK00095.
Enzyme and pathway databases
BioCyc	APLE434271:APJL_2005-MONOMER.
Family and domain databases
HAMAP	MF_00149. DNA_mis_repair. [Tree]
InterPro	IPR003594. ATPase-like_ATP-bd. IPR002099. DNA_mismatch_repair. IPR013507. DNA_mismatch_repair_C. IPR014762. DNA_mismatch_repair_CS. IPR020667. DNA_mismatch_repair_MutL. IPR014763. DNA_mismatch_repair_N. IPR014790. MutL_C. IPR020568. Ribosomal_S5_D2-typ_fold. IPR014721. Ribosomal_S5_D2-typ_fold_subgr. [Graphical view]
Gene3D	G3DSA:3.30.565.10. ATP_bd_ATPase. 1 hit. G3DSA:3.30.230.10. Ribosomal_S5_D2-type_fold. 1 hit.
KO	K03572.
PANTHER	PTHR10073. DNA_mis_repair. 1 hit.
Pfam	PF01119. DNA_mis_repair. 1 hit. PF02518. HATPase_c. 1 hit. PF08676. MutL_C. 1 hit. [Graphical view]
SMART	SM00387. HATPase_c. 1 hit. SM00853. MutL_C. 1 hit. [Graphical view]
SUPFAM	SSF55874. ATP_bd_ATPase. 1 hit. SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.
TIGRFAMs	TIGR00585. Mutl. 1 hit.
PROSITE	PS00058. DNA_MISMATCH_REPAIR_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

MUTL_ACTPJ

Accession

Primary (citable) accession number: B0BTY3

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 30 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program