B0BTW9 (B0BTW9_ACTPJ) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Recommended name:
Formate--tetrahydrofolate ligase HAMAP MF_01543
EC=6.3.4.3 HAMAP MF_01543

Alternative name(s):
Formyltetrahydrofolate synthetase HAMAP MF_01543

Gene names

Name:	fhs HAMAP MF_01543 EMBL ABY69074.1
Ordered Locus Names:	APJL_0493

Organism

Actinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP]

Taxonomic identifier

434271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	544 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate. HAMAP MF_01543 SAAS SAAS020628
Pathway	One-carbon metabolism; tetrahydrofolate interconversion. HAMAP MF_01543 SAAS SAAS020628
Sequence similarities	Belongs to the formate--tetrahydrofolate ligase family. HAMAP MF_01543

Ontologies

Keywords
Biological process	One-carbon metabolism HAMAP MF_01543 SAAS SAAS020628
Ligand	ATP-binding HAMAP MF_01543 SAAS SAAS020628 Nucleotide-binding
Molecular function	Ligase HAMAP MF_01543 SAAS SAAS020628 EMBL ABY69074.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	folic acid-containing compound biosynthetic process Inferred from electronic annotation. Source: InterPro one-carbon metabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	ATP binding Inferred from electronic annotation. Source: HAMAP formate-tetrahydrofolate ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Regions
	Nucleotide binding	52 – 59	8	ATP By similarity HAMAP MF_01543

Sequences

	Sequence		Length	Mass (Da)
	B0BTW9 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 08C2B18EF77C6546	FASTA	544	57,730
	10 20 30 40 50 60 MQPIHKIAEK LGLNADQIEQ YGKYKAKINP TDAFKLPAKN GKLILVTAIN PTPAGEGKTT 70 80 90 100 110 120 VTIGLTDALN QLGKNAVVAA REPSLGPVFG VKGGAAGGGY AQVLPMEDIN LHFTGDFHAI 130 140 150 160 170 180 TSANNLLAAL LDNHIYQGNA LNIDTKRVLW RRVIDMNDRQ LRNVLGGLGN PTDGVIRPDG 190 200 210 220 230 240 FYITVASEVM AIFCLAKDLA DLKTRLGNIL VAYTKDKQPV YAKDLNAHGA MAALLKDAIK 250 260 270 280 290 300 PNLVQTIEGS PAFIHGGPFA NIAHGCNSVT ATRLALHLGD YAVTEAGFGA DLGAEKFCDI 310 320 330 340 350 360 KCRLADLKPD VAVVVATVKA LKYNGGVEKA NLAEENLTAL QQGLPNLLKH ISNLKNVFGL 370 380 390 400 410 420 PVVVALNRFV SDTDAELALI QTACAKQGVE VSLTEVWGKG GAGGVDLAQK VLKAIDEQEN 430 440 450 460 470 480 RFNFVYDANE SVQNKIKAIA QKIYGADDVN FSAEALAEIK NLEKLGLDKL PICMAKTQYS 490 500 510 520 530 540 LSDNAKLLGC PSGFTVTVRS ISVSAGAGFI VAICGSIMRM PGLPKVPAAN RIDVDENGLI TGLF

References

[1]

"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China." Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H. PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000687 Genomic DNA. Translation: ABY69074.1.
RefSeq	YP_001651518.1. NC_010278.1.
3D structure databases
ProteinModelPortal	B0BTW9.
SMR	B0BTW9. Positions 1-542.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BTW9.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5851109.
GenomeReviews	Gene locus APJL_0493 in contig CP000687_GR.
KEGG	apj:APJL_0493.
PATRIC	20750220. VBIActPle136345_0497.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG677721.
OMA	TDFTVTI.
ProtClustDB	PRK13505.
Family and domain databases
HAMAP	MF_01543. FTHFS. [Tree]
InterPro	IPR000559. Formate_THF_ligase. IPR020628. Formate_THF_ligase_CS. [Graphical view]
KO	K01938.
Pfam	PF01268. FTHFS. 1 hit. [Graphical view]
PROSITE	PS00721. FTHFS_1. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

B0BTW9_ACTPJ

Accession

Primary (citable) accession number: B0BTW9

Entry history

Integrated into UniProtKB/TrEMBL:	February 26, 2008
Last sequence update:	February 26, 2008
Last modified:	December 14, 2011
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)