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Protein

Phosphoenolpyruvate carboxylase

Gene

ppc

Organism
Actinobacillus pleuropneumoniae serotype 3 (strain JL03)
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.UniRule annotationSAAS annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotationSAAS annotation

Cofactori

Mg2+UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381UniRule annotation
Active sitei545 – 5451UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Carbon dioxide fixationUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, PyruvateImported

Enzyme and pathway databases

BioCyciAPLE434271:GIX7-359-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylaseUniRule annotationSAAS annotation (EC:4.1.1.31UniRule annotationSAAS annotation)
Short name:
PEPCUniRule annotation
Short name:
PEPCaseUniRule annotation
Gene namesi
Name:ppcUniRule annotationImported
Ordered Locus Names:APJL_0355Imported
OrganismiActinobacillus pleuropneumoniae serotype 3 (strain JL03)Imported
Taxonomic identifieri434271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
ProteomesiUP000008547: Chromosome

Interactioni

Subunit structurei

Homotetramer.UniRule annotation

Protein-protein interaction databases

STRINGi434271.APJL_0355.

Structurei

3D structure databases

ProteinModelPortaliB0BT89.
SMRiB0BT89. Positions 5-879.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 1 family.UniRule annotation

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0BT89-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNQPYSAMRN NIHMLGDFLG ETIREAQGNE ILELIESIRV LSRDSRAGDE
60 70 80 90 100
KAREQLLDKL ANISTENVLP VARAFSQFLN LTNIAEQYQT ISRHHQDESL
110 120 130 140 150
GNRSLSALFA RLKAQSTPVE TVIKTVEKLL IELVLTAHPT EVTRRSLVHK
160 170 180 190 200
HVEINKCLGQ LEHDDLTEAE QTKLKRRLMQ LIALAWHTNE IRAARPTPVD
210 220 230 240 250
EAKWGMAIIE NSLWKAVPDF CRELNFQLEK HFDVQYEVAL SPVRFSSWMG
260 270 280 290 300
GDRDGNPFVT AEITQKVLRM NRWKAAELFL NDVSDLAEEL SIVQCTPEFR
310 320 330 340 350
EKYGDHIEPY RVVVKGLRSK LQKTLTYFGE LIEAKPTTVD PSEIITCDND
360 370 380 390 400
LWEPLYDCYQ SLHACGMRII ANGSLLDCLR RIRCFGLGLS RLDIRQESTR
410 420 430 440 450
HETAIAEITR YIGLGDYAQW TEDDKQAFLV RELSSRRPLV PTNWTPSPET
460 470 480 490 500
QEILDTCKVV AQQPEGTISA YVISMAREAS DVLAVHLLLK EAGCNYTLPV
510 520 530 540 550
APLFETLDDL DHSEKVMTDL FNIGWYRGVI NNYQMVMIGY SDSAKDAGML
560 570 580 590 600
AASWAQYRAQ EALVNLAEKY HIELVLFHGR GGTVGRGGAP AHAALLSQPP
610 620 630 640 650
RSLKSGLRVT EQGEMIRFKL GLPAVAVETL NLYASAILEA NLLPPPEPKQ
660 670 680 690 700
KWRDIMDKGA AISCEIYRGV VRGEPDFVPY FRSATPEQEL GKLPLGSRPS
710 720 730 740 750
KRNPNGGVES LRAIPWIFAW MQNRLMLPAW LGAGAALRQM IEQGEESTLK
760 770 780 790 800
EMCNEWPFFS TRIGMLEMVF SKADLWLAEH YDQRLVAKEL HRLGKTLRAQ
810 820 830 840 850
LSADIQTVLT LAHDGQLMAD LPWIAESIAL RNVYTDPLNL LQVELLQRLR
860 870
SQGEVRDPQL EQALMITITG IAAGMRNTG
Length:879
Mass (Da):99,186
Last modified:February 26, 2008 - v1
Checksum:iA771DC4256B57305
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000687 Genomic DNA. Translation: ABY68946.1.
RefSeqiWP_012262785.1. NC_010278.1.
YP_001651390.1. NC_010278.1.

Genome annotation databases

EnsemblBacteriaiABY68946; ABY68946; APJL_0355.
GeneIDi5851547.
KEGGiapj:APJL_0355.
PATRICi20749939. VBIActPle136345_0358.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000687 Genomic DNA. Translation: ABY68946.1.
RefSeqiWP_012262785.1. NC_010278.1.
YP_001651390.1. NC_010278.1.

3D structure databases

ProteinModelPortaliB0BT89.
SMRiB0BT89. Positions 5-879.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi434271.APJL_0355.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY68946; ABY68946; APJL_0355.
GeneIDi5851547.
KEGGiapj:APJL_0355.
PATRICi20749939. VBIActPle136345_0358.

Phylogenomic databases

eggNOGiCOG2352.
HOGENOMiHOG000238648.
KOiK01595.
OMAiCGMGVIA.
OrthoDBiEOG6TJ7T8.

Enzyme and pathway databases

BioCyciAPLE434271:GIX7-359-MONOMER.

Family and domain databases

HAMAPiMF_00595. PEPcase_type1.
InterProiIPR021135. PEP_COase.
IPR018129. PEP_COase_AS.
IPR022805. PEP_COase_bac/pln-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF00311. PEPcase. 1 hit.
[Graphical view]
PRINTSiPR00150. PEPCARBXLASE.
SUPFAMiSSF51621. SSF51621. 1 hit.
PROSITEiPS00781. PEPCASE_1. 1 hit.
PS00393. PEPCASE_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China."
    Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T.
    , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H.
    PLoS ONE 3:E1450-E1450(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: JL03Imported.

Entry informationi

Entry nameiB0BT89_ACTPJ
AccessioniPrimary (citable) accession number: B0BT89
Entry historyi
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: March 4, 2015
This is version 54 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.