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Protein

Membrane-bound lytic murein transglycosylase C

Gene

mltC

Organism
Actinobacillus pleuropneumoniae serotype 3 (strain JL03)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division.UniRule annotation

Catalytic activityi

Exolytic cleavage of the (1->4)-beta-glycosidic linkage between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc) residues in peptidoglycan, from either the reducing or the non-reducing ends of the peptidoglycan chains, with concomitant formation of a 1,6-anhydrobond in the MurNAc residue.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Cell wall biogenesis/degradation

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Names & Taxonomyi

Protein namesi
Recommended name:
Membrane-bound lytic murein transglycosylase CUniRule annotation (EC:4.2.2.n1UniRule annotation)
Alternative name(s):
Murein lyase CUniRule annotation
Gene namesi
Name:mltCUniRule annotation
Ordered Locus Names:APJL_1777
OrganismiActinobacillus pleuropneumoniae serotype 3 (strain JL03)
Taxonomic identifieri434271 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPasteurellalesPasteurellaceaeActinobacillus
Proteomesi
  • UP000008547 Componenti: Chromosome

Subcellular locationi

  • Cell outer membrane UniRule annotation; Lipid-anchor UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell outer membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 19UniRule annotationAdd BLAST19
ChainiPRO_100018591620 – 365Membrane-bound lytic murein transglycosylase CAdd BLAST346

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi20N-palmitoyl cysteineUniRule annotation1
Lipidationi20S-diacylglycerol cysteineUniRule annotation1

Keywords - PTMi

Lipoprotein, Palmitate

Structurei

3D structure databases

ProteinModelPortaliB0BSH0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the transglycosylase Slt family.UniRule annotation

Keywords - Domaini

Signal

Phylogenomic databases

HOGENOMiHOG000283572.
KOiK08306.
OMAiAIMQIES.
OrthoDBiPOG091H06EG.

Family and domain databases

HAMAPiMF_01616. MltC. 1 hit.
InterProiIPR023346. Lysozyme-like_dom.
IPR023664. Murein_transglycosylaseC.
IPR024570. Murein_transglycosylaseC_N.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF11873. DUF3393. 1 hit.
PF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0BSH0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKKYTKYLPL LLIIPFLAAC GSSSPKKSKR TKTRVDYNTK DTNGLDILTG
60 70 80 90 100
QFSHNIDDIW GSNELLVASK KDYVKYTDKF YTRSHISFED GQITIETLGD
110 120 130 140 150
QNHLRNSIIH TLLMGSDPKG IDLFASGDAP ISSNPFLAGQ VNDQFGRDIN
160 170 180 190 200
NIAIANDFAT YLIQNKLQTR RLQNGRTVTY VAIKMVAGHI EVRARQYLPL
210 220 230 240 250
VRKMAKRYGI EPSLILGIME VESAFNPYAV SYANAIGLMQ VVPRTAGRDI
260 270 280 290 300
FARKGFDGQP DRAYLYNPSQ NIDSGTLYLA ILRDEYLEGI TNPTAKRYAM
310 320 330 340 350
ISAYNSGAGA VLKVFDYDKY DAIDRINELS PDAVYRILTT AHPSSQARNY
360
LKKVSKAREK YLHIR
Length:365
Mass (Da):41,061
Last modified:February 26, 2008 - v1
Checksum:iA0122C00BE2F38F1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000687 Genomic DNA. Translation: ABY70327.1.
RefSeqiWP_005599253.1. NC_010278.1.

Genome annotation databases

EnsemblBacteriaiABY70327; ABY70327; APJL_1777.
GeneIDi4848883.
KEGGiapj:APJL_1777.
PATRICi20752880. VBIActPle136345_1769.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CP000687 Genomic DNA. Translation: ABY70327.1.
RefSeqiWP_005599253.1. NC_010278.1.

3D structure databases

ProteinModelPortaliB0BSH0.
ModBaseiSearch...
MobiDBiSearch...

Protein family/group databases

CAZyiGH23. Glycoside Hydrolase Family 23.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiABY70327; ABY70327; APJL_1777.
GeneIDi4848883.
KEGGiapj:APJL_1777.
PATRICi20752880. VBIActPle136345_1769.

Phylogenomic databases

HOGENOMiHOG000283572.
KOiK08306.
OMAiAIMQIES.
OrthoDBiPOG091H06EG.

Family and domain databases

HAMAPiMF_01616. MltC. 1 hit.
InterProiIPR023346. Lysozyme-like_dom.
IPR023664. Murein_transglycosylaseC.
IPR024570. Murein_transglycosylaseC_N.
IPR000189. Transglyc_AS.
IPR008258. Transglycosylase_SLT_dom_1.
[Graphical view]
PfamiPF11873. DUF3393. 1 hit.
PF01464. SLT. 1 hit.
[Graphical view]
SUPFAMiSSF53955. SSF53955. 1 hit.
PROSITEiPS51257. PROKAR_LIPOPROTEIN. 1 hit.
PS00922. TRANSGLYCOSYLASE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMLTC_ACTPJ
AccessioniPrimary (citable) accession number: B0BSH0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 28, 2009
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 56 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.