Reviewed, UniProtKB/Swiss-Prot B0BS17 (DCUP_ACTPJ)

Names and origin

Protein names

Recommended name:
    Uroporphyrinogen decarboxylase
      Short name=URO-D
      Short name=UPD
    EC=4.1.1.37

Gene names

Name:	hemE
Ordered Locus Names:	APJL_0113

Organism

Actinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP]

Taxonomic identifier

434271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III By similarity.
Catalytic activity	Uroporphyrinogen III = coproporphyrinogen + 4 CO2. HAMAP MF_00218
Pathway	Porphyrin metabolism; protoporphyrin-IX biosynthesis; coproporphyrinogen-III from 5-aminolevulinate: step 4/4. HAMAP MF_00218
Subunit structure	Homodimer By similarity.
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the uroporphyrinogen decarboxylase family.

Ontologies

Keywords
Biological process	Porphyrin biosynthesis
Cellular component	Cytoplasm
Molecular function	Decarboxylase Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	uroporphyrinogen decarboxylase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Uroporphyrinogen decarboxylase HAMAP MF_00218		PRO_1000099971
Regions
	Region	27 – 31	5	Substrate binding By similarity
Sites
	Binding site	77	1	Substrate By similarity
	Binding site	154	1	Substrate By similarity
	Binding site	209	1	Substrate By similarity
	Binding site	327	1	Substrate By similarity
	Site	77	1	Transition state stabilizer By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0BS17-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 3DDD7FA9BA3691D6	FASTA	354	39,331
	10 20 30 40 50 60 MNQLKNDRYL KALLREPVDM TPVWMMRQAG RYLPEYKATR AEAGDFMALC RNADLACEVT 70 80 90 100 110 120 LQPLRRYALD AAILFSDILT VPDAMGLGLS FGAGEGPKFA RPIENKAQVD NLPIPDPESE 130 140 150 160 170 180 LQYVMNAVRT IRRELKGEVP LIGFSGSPWT LATYMVEGGS SKAFTKIKKM MYADPQILHA 190 200 210 220 230 240 LLDKLADSVI LYLNAQIKAG AQAVMVFDTW GGVLAHNEYK AFSLRYMHKI VDGLIRENEG 250 260 270 280 290 300 RKVPVTLFTK GGGLWLEAIA ETGCDAVGLD WTIDIADARR RVGHKVALQG NMDPSVLYAQ 310 320 330 340 350 PERIEQEVKQ ILAGFGQGSG HVFNLGHGIH QDVPEQSPKV FVDAVHEYSK QYHK

References

[1]

"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China." Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H. PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000687 Genomic DNA. Translation: ABY68717.1.
RefSeq	YP_001651161.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5851531.
GenomeReviews	Gene locus APJL_0113 in contig CP000687_GR.
KEGG	apj:APJL_0113.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VFTKGGG.
Family and domain databases
HAMAP	MF_00218. [Tree]
InterPro	IPR006361. Uroporphyrinogen_deCO2ase_HemE. IPR000257. Uroporphyrinogen_deCOase. [Graphical view]
PANTHER	PTHR21091:SF2. HemE. 1 hit.
Pfam	PF01208. URO-D. 1 hit. [Graphical view]
ProDom	PD003225. Uro_decarbxyls. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01464. hemE. 1 hit.
PROSITE	PS00906. UROD_1. 1 hit. PS00907. UROD_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

DCUP_ACTPJ

Accession

Primary (citable) accession number: B0BS17

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)