Reviewed,
UniProtKB/Swiss-Prot B0BRH9 (DDL_ACTPJ)
Last modified
June 16, 2009.
Version 13.
History...
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90%,
50% identity |
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: D-alanine--D-alanine ligase EC=6.3.2.4 Alternative name(s): D-alanylalanine synthetase D-Ala-D-Ala ligase | ||||
| Gene names |
| ||||
| Organism | Actinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 434271 [NCBI] | ||||
| Taxonomic lineage | Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus |
Protein attributes
| Sequence length | 303 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Function | Cell wall formation By similarity. |
| Catalytic activity | ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine. HAMAP MF_00047 |
| Cofactor | Binds 2 magnesium or manganese ions per subunit By similarity. |
| Pathway | Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00047 |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the D-alanine--D-alanine ligase family. Contains 1 ATP-grasp domain. |
Ontologies
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 303 | 303 | D-alanine--D-alanine ligase HAMAP MF_00047 | PRO_0000341047 | |||||
Regions | |||||||||
| Domain | 104 – 300 | 197 | ATP-grasp | ||||||
| Nucleotide binding | 132 – 187 | 56 | ATP By similarity | ||||||
Sites | |||||||||
| Metal binding | 254 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 267 | 1 | Magnesium or manganese 1 By similarity | ||||||
| Metal binding | 267 | 1 | Magnesium or manganese 2 By similarity | ||||||
| Metal binding | 269 | 1 | Magnesium or manganese 2 By similarity | ||||||
Sequences
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References
| [1] | "Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China." Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. Chen H.PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. |
Cross-references
Sequence databases | |
|---|---|
| CP000687 Genomic DNA. Translation: ABY68627.1. | |
| RefSeq | YP_001651071.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 5851576. |
| GenomeReviews | Gene locus APJL_0021 in contig CP000687_GR. |
| KEGG | apj:APJL_0021. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| OMA | B0BRH9. RAFIILH. |
Family and domain databases | |
| HAMAP | MF_00047. [Tree] |
| InterPro | IPR011761. ATP-grasp. IPR013816. ATP_grasp_subdomain_2. IPR000291. D-Ala_lig_Van_CS. IPR005905. D_ala_D_ala. IPR011095. Dala_Dala_lig_C. IPR011127. Dala_Dala_lig_N. IPR013817. Pre-ATP_grasp. [Graphical view] |
| Gene3D | G3DSA:3.30.470.20. ATP_grasp_subdomain_2. 1 hit. G3DSA:3.40.50.20. Pre-ATP_grasp. 1 hit. |
| Pfam | PF07478. Dala_Dala_lig_C. 1 hit. PF01820. Dala_Dala_lig_N. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01205. D_ala_D_alaTIGR. 1 hit. |
| PROSITE | PS50975. ATP_GRASP. 1 hit. PS00843. DALA_DALA_LIGASE_1. 1 hit. PS00844. DALA_DALA_LIGASE_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | DDL_ACTPJ | ||||||||
| Accession | Primary (citable) accession number: B0BRH9 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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