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B0BRH4 (MRAY_ACTPJ) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 38. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Phospho-N-acetylmuramoyl-pentapeptide-transferase
EC=2.7.8.13
Alternative name(s):
UDP-MurNAc-pentapeptide phosphotransferase
Gene names
Name:mraY
Ordered Locus Names:APJL_0016
OrganismActinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP]
Taxonomic identifier434271 [NCBI]
Taxonomic lineageBacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length360 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan By similarity. HAMAP MF_00038

Catalytic activity

UDP-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala) + undecaprenyl phosphate = UMP + Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol. HAMAP MF_00038

Pathway

Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00038

Subcellular location

Cell inner membrane; Multi-pass membrane protein By similarity HAMAP MF_00038.

Sequence similarities

Belongs to the glycosyltransferase 4 family. MraY subfamily.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 360360Phospho-N-acetylmuramoyl-pentapeptide-transferase HAMAP MF_00038
PRO_1000090585

Regions

Transmembrane21 – 4121Helical; Potential
Transmembrane73 – 9321Helical; Potential
Transmembrane98 – 11821Helical; Potential
Transmembrane132 – 15221Helical; Potential
Transmembrane168 – 18821Helical; Potential
Transmembrane199 – 21921Helical; Potential
Transmembrane236 – 25621Helical; Potential
Transmembrane263 – 28321Helical; Potential
Transmembrane288 – 30821Helical; Potential
Transmembrane338 – 35821Helical; Potential

Sequences

Sequence LengthMass (Da)Tools
B0BRH4 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 1470ADC8F78B7398

FASTA36040,126
        10         20         30         40         50         60 
MLVWLAEYLV QYNTAFNVVS YITFRAIMAL LTAMGIGLWI GPEVIRRLQL LKFGQEVRND 

        70         80         90        100        110        120 
GPESHFKKRG TPTMGGIMIL IAIGVSTLLW ADLRNSYVWF VLFVLFGYGA VGFVDDYWKI 

       130        140        150        160        170        180 
KRKNTDGLIA RWKYFWLSVI ALIAVFGIYA VGKDTAATQL VVPFFKDFMP QLGIFFIILS 

       190        200        210        220        230        240 
YFVIVGTSNA VNLTDGLDGL AIVPTIMVAS AFALIAWATG NFNFAQYLHI PFVPNAGELV 

       250        260        270        280        290        300 
ILCTAIVGAG LGFLWYNTYP AQVFMGDVGS LSLGGALGTI AVLVRQELLL VIMGGVFVVE 

       310        320        330        340        350        360 
ALSVILQVGS YKLRQKRIFR MAPIHHHFEL KGWPEPRVIV RFWIITLMLV LIGLVTLKLR

« Hide

References

[1]"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China."
Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. expand/collapse author list , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H.
PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: JL03.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		CP000687 Genomic DNA. Translation: ABY68622.1.
RefSeqYP_001651066.1. NC_010278.1.

3D structure databases

ModBaseSearch...

Protein-protein interaction databases

STRINGB0BRH4.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID5851572.
GenomeReviewsGene locus APJL_0016 in contig CP000687_GR.
KEGGapj:APJL_0016.
PATRIC20749231. VBIActPle136345_0017.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG708263.
OMARFWIISM.
ProtClustDBPRK00108.

Enzyme and pathway databases

BioCycAPLE434271:APJL_0016-MONOMER.

Family and domain databases

HAMAPMF_00038. MraY.
[Tree]
InterProIPR000715. Glycosyl_transferase_4.
IPR003524. PNAcMuramoyl-5peptid_Trfase.
IPR018480. PNAcMuramoyl-5peptid_Trfase_CS.
[Graphical view]
KOK01000.
PANTHERPTHR22926. Glyco_trans_4. 1 hit.
PTHR22926:SF3. PNAcPpept_trans. 1 hit.
PfamPF00953. Glycos_transf_4. 1 hit.
PF10555. MraY_sig1. 1 hit.
[Graphical view]
TIGRFAMsTIGR00445. MraY. 1 hit.
PROSITEPS01347. MRAY_1. 1 hit.
PS01348. MRAY_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameMRAY_ACTPJ
AccessionPrimary (citable) accession number: B0BRH4
Entry history
Integrated into UniProtKB/Swiss-Prot: March 24, 2009
Last sequence update: February 26, 2008
Last modified: January 25, 2012
This is version 38 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

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