Reviewed, UniProtKB/Swiss-Prot B0BQC2 (ARLY_ACTPJ)

Names and origin

Protein names

Recommended name:
    Argininosuccinate lyase
      Short name=ASAL
    EC=4.3.2.1
Alternative name(s):
    Arginosuccinase

Gene names

Name:	argH
Ordered Locus Names:	APJL_1201

Organism

Actinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP]

Taxonomic identifier

434271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP MF_00006
Pathway	Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP MF_00006
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Arginine biosynthesis
Cellular component	Cytoplasm
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	arginine biosynthetic process via ornithine Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	argininosuccinate lyase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Argininosuccinate lyase HAMAP MF_00006		PRO_1000089063

Sequences

	Sequence		Length	Mass (Da)
	B0BQC2-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 20173739F8A819A0	FASTA	458	51,046
	10 20 30 40 50 60 MALWGGRFKQ EADAKFKFFN DSLRFDYRLA LQDIDGSIGW AKAITSVGIL TEQEHQQLVV 70 80 90 100 110 120 ALKELRAEIE PNIAIILRDD AEDIHSWVES KLIEKVGDLG KKLHTGRSRN DQVAVDMKMW 130 140 150 160 170 180 CKVQAVVLQE RIRNLQHKLV ETAEANQNAV MPGYTHLQRA QPITFAHWCM AYYEMLERDF 190 200 210 220 230 240 SRLTDAYKRM HTCPLGSGAL AGTAYSIDRD ALAQDLGFAI GTRNSLDSVS DRDHVLELLS 250 260 270 280 290 300 TASISMVHLS RFAEDLIFFN SGESAFLELS DRVTSGSSLM PQKKNPDACE LIRGKSGRVF 310 320 330 340 350 360 GALSGLLTTL KGLPLAYNKD MQEDKEGIFD AMETWQACLE IGALVLEDIN VNVERTREAA 370 380 390 400 410 420 QQGYSNATEL ADYLVAKGIP FREAHHIVGE AVVYAISKRE PLEALSVAEF KQFHPVIDED 430 440 450 VYPILSLESC LEKRSAKGGV NPERVREAIE AAKVNLGA

References

[1]

"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China." Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H. PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000687 Genomic DNA. Translation: ABY69757.1.
RefSeq	YP_001652201.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5850840.
GenomeReviews	Gene locus APJL_1201 in contig CP000687_GR.
KEGG	apj:APJL_1201.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	MAEDLIF.
Family and domain databases
HAMAP	MF_00006. [Tree]
InterPro	IPR009049. Argininosuccinate_lyase. IPR003031. D_crystallin. IPR000362. Fumarate_lyase. IPR020557. Fumarate_lyase_CS. [Graphical view]
PANTHER	PTHR11444:SF3. argH. 1 hit.
Pfam	PF00206. Lyase_1. 1 hit. [Graphical view]
PRINTS	PR00145. ARGSUCLYASE. PR00149. FUMRATELYASE.
TIGRFAMs	TIGR00838. argH. 1 hit.
PROSITE	PS00163. FUMARATE_LYASES. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

ARLY_ACTPJ

Accession

Primary (citable) accession number: B0BQC2

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 15 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)