B0BQ77 (G6PI_ACTPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Glucose-6-phosphate isomerase
Short name=GPI
EC=5.3.1.9

Alternative name(s):
Phosphoglucose isomerase
Short name=PGI
Phosphohexose isomerase
Short name=PHI

Gene names

Name:	pgi
Ordered Locus Names:	APJL_1156

Organism

Actinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP]

Taxonomic identifier

434271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	546 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	D-glucose 6-phosphate = D-fructose 6-phosphate. HAMAP MF_00473
Pathway	Carbohydrate biosynthesis; gluconeogenesis. HAMAP MF_00473 Carbohydrate degradation; glycolysis; D-glyceraldehyde 3-phosphate and glycerone phosphate from D-glucose: step 2/4. HAMAP MF_00473
Subcellular location	Cytoplasm By similarity HAMAP MF_00473.
Sequence similarities	Belongs to the GPI family.

Ontologies

Keywords
Biological process	Gluconeogenesis Glycolysis
Cellular component	Cytoplasm
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	gluconeogenesis Inferred from electronic annotation. Source: UniProtKB-KW glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	glucose-6-phosphate isomerase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 546	546	Glucose-6-phosphate isomerase HAMAP MF_00473		PRO_1000125687
Sites
	Active site	384	1	By similarity
	Active site	512	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	B0BQ77 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 74397AC94F086CB1	FASTA	546	60,385
	10 20 30 40 50 60 MQNINPTQTA AWSALEQHKA DNLNIPQLFA EDANRFDKYH LNFEQQILVD FSKNAINQKT 70 80 90 100 110 120 LELLRQLANE CGLASATEAM FSGQKINRTE NRAVLHTALR NRSNTPVLVD GKDVMPEVNA 130 140 150 160 170 180 VLAKMKDFCE RIISGSWKGY TGKAITDVIN IGIGGSDLGP YMVTEALRPY KNHLNMHFVS 190 200 210 220 230 240 NVDGTHIAEV LKKVNPETTL VLVASKTFTT QETMANALTA REWLLAAVKD ESAVAKHFAA 250 260 270 280 290 300 LSTNAKEVAK FGIDTANMFE FWDWVGGRYS LWSAIGLSIA LSLGFENFEA LLSGAHAMDN 310 320 330 340 350 360 HFRTAPIEKN IPTTLALIGI WNSNFLGAET EALLPYDQYL HRFAAYFQQG NMESNGKFVG 370 380 390 400 410 420 RDGSPVTHQT GPIVWGEPGT NGQHAFYQLI HQGTKLIPCD FIAPAQTHNP VGDHHAKLLS 430 440 450 460 470 480 NFFAQTEALA FGKSKETVEA EFVAAGKNLA DVAEIVPFKV FTGNKPTNSI LVQKITPFTL 490 500 510 520 530 540 GALIAMYEHK IFVQGVIFNI YSFDQWGVEL GKQLANRILP ELQNAEKISS HDSSTNGLIN QFKAWR

References

[1]

"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China." Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H. PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JL03.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000687 Genomic DNA. Translation: ABY69712.1.
RefSeq	YP_001652156.1. NC_010278.1.
3D structure databases
ProteinModelPortal	B0BQ77.
SMR	B0BQ77. Positions 17-546.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BQ77.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5850864.
GenomeReviews	Gene locus APJL_1156 in contig CP000687_GR.
KEGG	apj:APJL_1156.
PATRIC	20751548. VBIActPle136345_1150.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG352954.
OMA	GPKIVSQ.
ProtClustDB	PRK00179.
Enzyme and pathway databases
BioCyc	APLE434271:APJL_1156-MONOMER.
Family and domain databases
HAMAP	MF_00473. G6P_isomerase. [Tree]
InterPro	IPR001672. G6P_Isomerase. IPR023096. G6P_Isomerase_C. IPR018189. Phosphoglucose_isomerase_CS. [Graphical view]
Gene3D	G3DSA:1.10.1390.10. G6P_Isomerase_C. 1 hit.
KO	K01810.
PANTHER	PTHR11469. G6P_Isomerase. 1 hit.
Pfam	PF00342. PGI. 1 hit. [Graphical view]
PRINTS	PR00662. G6PISOMERASE.
PROSITE	PS00765. P_GLUCOSE_ISOMERASE_1. 1 hit. PS00174. P_GLUCOSE_ISOMERASE_2. 1 hit. PS51463. P_GLUCOSE_ISOMERASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

G6PI_ACTPJ

Accession

Primary (citable) accession number: B0BQ77

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 27 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program