B0BQ73 (COAD_ACTPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Phosphopantetheine adenylyltransferase
EC=2.7.7.3

Alternative name(s):
Dephospho-CoA pyrophosphorylase
Pantetheine-phosphate adenylyltransferase
Short name=PPAT

Gene names

Name:	coaD
Ordered Locus Names:	APJL_1152

Organism

Actinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP]

Taxonomic identifier

434271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	158 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate By similarity. HAMAP MF_00151
Catalytic activity	ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA. HAMAP MF_00151
Pathway	Cofactor biosynthesis; coenzyme A biosynthesis; CoA from (R)-pantothenate: step 4/5. HAMAP MF_00151
Subunit structure	Homohexamer By similarity. HAMAP MF_00151
Subcellular location	Cytoplasm By similarity HAMAP MF_00151.
Sequence similarities	Belongs to the bacterial CoaD family.

Ontologies

Keywords
Biological process	Coenzyme A biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	coenzyme A biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW pantetheine-phosphate adenylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 158	158	Phosphopantetheine adenylyltransferase HAMAP MF_00151		PRO_1000096756

Sequences

	Sequence		Length	Mass (Da)
	B0BQ73 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: E4CEF79A398F288B	FASTA	158	17,552
	10 20 30 40 50 60 MSYTVIYAGT FDPMTNGHLD IIERASELFG QVIVAVAKNP SKQPLFSLEE RTALVRQSCA 70 80 90 100 110 120 HLANVQAVGF SGLLADFAKQ HQAKALVRGI RGSDDIEYEI QLAQLNDKLS GRLDTVFLPP 130 140 150 SVTWRYLSST MVREIYRHQG DVAQFVPNAV LCALKEKE

References

[1]

"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China." Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H. PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JL03.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000687 Genomic DNA. Translation: ABY69708.1.
RefSeq	YP_001652152.1. NC_010278.1.
3D structure databases
ProteinModelPortal	B0BQ73.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BQ73.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5850886.
GenomeReviews	Gene locus APJL_1152 in contig CP000687_GR.
KEGG	apj:APJL_1152.
PATRIC	20751540. VBIActPle136345_1146.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG288308.
OMA	AMSDFEY.
ProtClustDB	PRK00168.
Enzyme and pathway databases
BioCyc	APLE434271:APJL_1152-MONOMER.
Family and domain databases
HAMAP	MF_00151. PPAT_bact. [Tree]
InterPro	IPR004821. Cyt_trans-rel. IPR004820. Cytidylyltransf. IPR001980. LPS_biosynth. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
KO	K00954.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
PRINTS	PR01020. LPSBIOSNTHSS.
TIGRFAMs	TIGR01510. CoaD_prev_kdtB. 1 hit. TIGR00125. Cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COAD_ACTPJ

Accession

Primary (citable) accession number: B0BQ73

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 35 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program