Reviewed, UniProtKB/Swiss-Prot B0BQ30 (PUR5_ACTPJ)

Names and origin

Protein names

Recommended name:
    Phosphoribosylformylglycinamidine cyclo-ligase
    EC=6.3.3.1
Alternative name(s):
    AIRS
    Phosphoribosyl-aminoimidazole synthetase
    AIR synthase

Gene names

Name:	purM
Ordered Locus Names:	APJL_1109

Organism

Actinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP]

Taxonomic identifier

434271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	345 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole. HAMAP MF_00741
Pathway	Purine metabolism; IMP biosynthesis via de novo pathway; 5-amino-1-(5-phospho-D-ribosyl)imidazole from N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide: step 2/2. HAMAP MF_00741
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the AIR synthase family.

Ontologies

Keywords
Biological process	Purine biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding Nucleotide-binding
Molecular function	Ligase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	'de novo' IMP biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW phosphoribosylformylglycinamidine cyclo-ligase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 345	345	Phosphoribosylformylglycinamidine cyclo-ligase HAMAP MF_00741		PRO_1000192987

Sequences

	Sequence		Length	Mass (Da)
	B0BQ30-1 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: EFFC3A21C33411CD	FASTA	345	36,867
	10 20 30 40 50 60 MSNTQLSYKD AGVDIHAGNE LVERIKGDVK RTRRPEVMGG LGGFGALCAL PTKYKEPILV 70 80 90 100 110 120 SGTDGVGTKL RLAIDLNKHD TIGQDLVAMC VNDLVVQGAE PLFFLDYYAT GKLEVDVAAD 130 140 150 160 170 180 VIKGIADGCE ISGCALVGGE TAEMPGMYHE GDYDLAGFCV GVVEKSEIID GSAVKAGDVL 190 200 210 220 230 240 LALASSGPHS NGYSLIRKVI EVSGANPATD TLEGKPLSEH LLAPTKIYVK SVLQLIKQAD 250 260 270 280 290 300 VHAIAHLTGG GFWENIPRVL PATAKAVIDE KSWEWPAAFK WLQEKGNISR YEMYRTFNCG 310 320 330 340 VGMVIALPEK DIETALAVLK QAGENAWVIG KIENLGEGSE QVEII

References

[1]

"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China." Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H. PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Cross-references

Sequence databases
EMBLGenBankDDBJ	CP000687 Genomic DNA. Translation: ABY69665.1.
RefSeq	YP_001652109.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	5852167.
GenomeReviews	Gene locus APJL_1109 in contig CP000687_GR.
KEGG	apj:APJL_1109.
Organism-specific databases
CMR	Search...
Phylogenomic databases
OMA	VHGLAHI.
Family and domain databases
HAMAP	MF_00741. [Tree]
InterPro	IPR000728. AIR_synth. IPR010918. AIR_synth_C. IPR004733. PurM_cligase. [Graphical view]
Pfam	PF00586. AIRS. 1 hit. PF02769. AIRS_C. 1 hit. [Graphical view]
TIGRFAMs	TIGR00878. purM. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PUR5_ACTPJ

Accession

Primary (citable) accession number: B0BQ30

Entry history

Integrated into UniProtKB/Swiss-Prot:	April 14, 2009
Last sequence update:	February 26, 2008
Last modified:	November 3, 2009
This is version 17 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)