B0BP27 (AROC_ACTPJ) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Chorismate synthase
EC=4.2.3.5

Alternative name(s):
5-enolpyruvylshikimate-3-phosphate phospholyase

Gene names

Name:	aroC
Ordered Locus Names:	APJL_0749

Organism

Actinobacillus pleuropneumoniae serotype 3 (strain JL03) [Complete proteome] [HAMAP]

Taxonomic identifier

434271 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Pasteurellales › Pasteurellaceae › Actinobacillus

Protein attributes

Sequence length	360 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate. HAMAP MF_00300
Cofactor	Reduced flavin By similarity. HAMAP MF_00300
Pathway	Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 7/7. HAMAP MF_00300
Subunit structure	Homotetramer By similarity. HAMAP MF_00300
Sequence similarities	Belongs to the chorismate synthase family.

Ontologies

Keywords
Biological process	Amino-acid biosynthesis Aromatic amino acid biosynthesis
Molecular function	Lyase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chorismate synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 360	360	Chorismate synthase HAMAP MF_00300		PRO_1000115323

Sequences

	Sequence		Length	Mass (Da)
	B0BP27 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 669FE8A217E9AED6	FASTA	360	38,951
	10 20 30 40 50 60 MAGNSIGQLF KVTTFGESHG IALGCIVDGV PPNMALSEAD IQPDLDRRKP GTSRYTTPRR 70 80 90 100 110 120 EDDEVQILSG VFEGKTTGTS IGLIIKNADQ RSKDYGDIAD KFRPGHADYT YQQKYGIRDY 130 140 150 160 170 180 RGGGRSSARE TAMRVAAGAI AKKYLREQFG IEVRGYLSQI GNVKINPETV ADISKIDWQQ 190 200 210 220 230 240 VASNPFFCPD PVAVEGFDEL IRELKKDGDS IGAKLTVVAE NVPVGLGEPV FDRLDADLAH 250 260 270 280 290 300 ALMSINAVKA VEIGDGFDVV EQRGSEHRDE MTPQGFVSNH AGGILGGISS GQPIIAHIAL 310 320 330 340 350 360 KPTSSIMVPG RSVNLNNEQV ELITKGRHDP CVGIRAVPIA EAMTAIILLD HLLRFKAQCR

References

[1]

"Genome biology of Actinobacillus pleuropneumoniae JL03, an isolate of serotype 3 prevalent in China." Xu Z., Zhou Y., Li L., Zhou R., Xiao S., Wan Y., Zhang S., Wang K., Li W., Li L., Jin H., Kang M., Dalai B., Li T., Liu L., Cheng Y., Zhang L., Xu T. , Zheng H., Pu S., Wang B., Gu W., Zhang X.L., Zhu G.-F., Wang S., Zhao G.-P., Chen H. PLoS ONE 3:E1450-E1450(2008) [PubMed: 18197260] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: JL03.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CP000687 Genomic DNA. Translation: ABY69312.1.
RefSeq	YP_001651756.1. NC_010278.1.
3D structure databases
ProteinModelPortal	B0BP27.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BP27.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	5852632.
GenomeReviews	Gene locus APJL_0749 in contig CP000687_GR.
KEGG	apj:APJL_0749.
PATRIC	20750739. VBIActPle136345_0753.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG292336.
OMA	SRFTTQR.
ProtClustDB	PRK05382.
Enzyme and pathway databases
BioCyc	APLE434271:APJL_0749-MONOMER.
Family and domain databases
HAMAP	MF_00300. Chorismate_synth. [Tree]
InterPro	IPR000453. Chorismate_synth. IPR020541. Chorismate_synthase_CS. [Graphical view]
KO	K01736.
PANTHER	PTHR21085. Chorismate_synth. 1 hit.
Pfam	PF01264. Chorismate_synt. 1 hit. [Graphical view]
PIRSF	PIRSF001456. Chorismate_synth. 1 hit.
SUPFAM	SSF103263. Chorismate_synth. 1 hit.
TIGRFAMs	TIGR00033. AroC. 1 hit.
PROSITE	PS00787. CHORISMATE_SYNTHASE_1. 1 hit. PS00788. CHORISMATE_SYNTHASE_2. 1 hit. PS00789. CHORISMATE_SYNTHASE_3. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

AROC_ACTPJ

Accession

Primary (citable) accession number: B0BP27

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 24, 2009
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 28 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program