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Protein

Carbonic anhydrase 1

Gene

Ca1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Reversible hydration of carbon dioxide.Curated

Catalytic activityi

H2CO3 = CO2 + H2O.By similarity

Cofactori

Zn2+By similarity

Enzyme regulationi

Inhibited by acetazolamide.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei65Proton acceptorPROSITE-ProRule annotation1
Metal bindingi95Zinc 1; catalyticBy similarity1
Metal bindingi95Zinc; catalyticBy similarity1
Metal bindingi97Zinc 1; catalyticBy similarity1
Metal bindingi97Zinc; catalyticBy similarity1
Metal bindingi120Zinc 1; catalyticBy similarity1
Metal bindingi120Zinc; catalyticBy similarity1
Active sitei129By similarity1
Binding sitei200SubstrateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLyase
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-RNO-1237044. Erythrocytes take up carbon dioxide and release oxygen.
R-RNO-1247673. Erythrocytes take up oxygen and release carbon dioxide.
R-RNO-1475029. Reversible hydration of carbon dioxide.

Names & Taxonomyi

Protein namesi
Recommended name:
Carbonic anhydrase 1By similarity (EC:4.2.1.1)
Alternative name(s):
Carbonate dehydratase IBy similarity
Carbonic anhydrase IBy similarity
Short name:
CA-IBy similarity
Gene namesi
Name:Ca1By similarity
Synonyms:Car1Imported
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi1309780. Ca1.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003491202 – 261Carbonic anhydrase 1By similarityAdd BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiB0BNN3.
PeptideAtlasiB0BNN3.
PRIDEiB0BNN3.

PTM databases

iPTMnetiB0BNN3.
PhosphoSitePlusiB0BNN3.

Expressioni

Gene expression databases

BgeeiENSRNOG00000010698.
GenevisibleiB0BNN3. RN.

Interactioni

Protein-protein interaction databases

BioGridi259578. 1 interactor.
IntActiB0BNN3. 1 interactor.
STRINGi10116.ENSRNOP00000014267.

Structurei

3D structure databases

ProteinModelPortaliB0BNN3.
SMRiB0BNN3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 261Alpha-carbonic anhydrasePROSITE-ProRule annotationAdd BLAST258

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni200 – 201Substrate bindingBy similarity2

Sequence similaritiesi

Belongs to the alpha-carbonic anhydrase family.Sequence analysis

Phylogenomic databases

eggNOGiKOG0382. Eukaryota.
COG3338. LUCA.
GeneTreeiENSGT00760000118915.
HOGENOMiHOG000112637.
HOVERGENiHBG002837.
InParanoidiB0BNN3.
KOiK01672.
OMAiVTWIICK.
OrthoDBiEOG091G0XFM.
PhylomeDBiB0BNN3.
TreeFamiTF316425.

Family and domain databases

Gene3Di3.10.200.10. 1 hit.
InterProiView protein in InterPro
IPR001148. Carbonic_anhydrase_a.
IPR023561. Carbonic_anhydrase_a-class.
IPR018338. Carbonic_anhydrase_a-class_CS.
IPR018442. Carbonic_anhydrase_CA1.
PANTHERiPTHR18952. PTHR18952. 1 hit.
PTHR18952:SF132. PTHR18952:SF132. 1 hit.
PfamiView protein in Pfam
PF00194. Carb_anhydrase. 1 hit.
SMARTiView protein in SMART
SM01057. Carb_anhydrase. 1 hit.
SUPFAMiSSF51069. SSF51069. 1 hit.
PROSITEiView protein in PROSITE
PS00162. ALPHA_CA_1. 1 hit.
PS51144. ALPHA_CA_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0BNN3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASADWGYDS KNGPDQWSKL YPIANGNNQS PIDIKTSEAK HDSSLKPVSV
60 70 80 90 100
SYNPATAKEI VNVGHSFHVV FDDSSNQSVL KGGPLADSYR LTQFHFHWGN
110 120 130 140 150
SNDHGSEHTV DGAKYSGELH LVHWNSAKYS SAAEAISKAD GLAIIGVLMK
160 170 180 190 200
VGPANPNLQK VLDALSSVKT KGKRAPFTNF DPSSLLPSSL DYWTYFGSLT
210 220 230 240 250
HPPLHESVTW VICKESISLS PEQLAQLRGL LSSAEGEPAV PVLSNHRPPQ
260
PLKGRTVRAS F
Length:261
Mass (Da):28,300
Last modified:February 26, 2008 - v1
Checksum:iDEF19D7C46E92171
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
CH473961 Genomic DNA. Translation: EDM00961.1.
BC158888 mRNA. Translation: AAI58889.1.
RefSeqiNP_001101130.1. NM_001107660.1.
XP_006232173.1. XM_006232111.1.
XP_008759064.1. XM_008760842.1.
UniGeneiRn.6854.

Genome annotation databases

EnsembliENSRNOT00000014267; ENSRNOP00000014267; ENSRNOG00000010698.
GeneIDi310218.
KEGGirno:310218.
UCSCiRGD:1309780. rat.

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.

Entry informationi

Entry nameiCAH1_RAT
AccessioniPrimary (citable) accession number: B0BNN3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: February 26, 2008
Last modified: May 10, 2017
This is version 74 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families