B0BNN3 (CAH1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Carbonic anhydrase 1
EC=4.2.1.1

Alternative name(s):
Carbonate dehydratase I
Carbonic anhydrase I
Short name=CA-I

Gene names

Name:	Ca1
Synonyms:	Car1

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	261 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Reversible hydration of carbon dioxide.
Catalytic activity	H2CO3 = CO2 + H2O. UniProtKB P00915
Cofactor	Zinc By similarity. UniProtKB P00915
Enzyme regulation	Inhibited by acetazolamide By similarity.
Subcellular location	Cytoplasm Ref.3.
Sequence similarities	Belongs to the alpha-carbonic anhydrase family.

Ontologies

Keywords
Cellular component	Cytoplasm
Ligand	Metal-binding Zinc
Molecular function	Lyase
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	one-carbon metabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	carbonate dehydratase activity Inferred from electronic annotation. Source: EC zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Initiator methionine	1	1	Removed By similarity UniProtKB P00915
	Chain	2 – 261	260	Carbonic anhydrase 1 UniProtKB P00915		PRO_0000349120
Regions
	Region	200 – 201	2	Substrate binding By similarity
Sites
	Active site	65	1	Proton acceptor By similarity
	Active site	129	1	By similarity
	Metal binding	95	1	Zinc; catalytic By similarity UniProtKB P00915
	Metal binding	97	1	Zinc; catalytic By similarity UniProtKB P00915
	Metal binding	120	1	Zinc; catalytic By similarity UniProtKB P00915
	Binding site	200	1	Substrate By similarity
Amino acid modifications
	Modified residue	2	1	N-acetylalanine By similarity UniProtKB P00915

Sequences

	Sequence		Length	Mass (Da)
	B0BNN3 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: DEF19D7C46E92171	FASTA	261	28,300
	10 20 30 40 50 60 MASADWGYDS KNGPDQWSKL YPIANGNNQS PIDIKTSEAK HDSSLKPVSV SYNPATAKEI 70 80 90 100 110 120 VNVGHSFHVV FDDSSNQSVL KGGPLADSYR LTQFHFHWGN SNDHGSEHTV DGAKYSGELH 130 140 150 160 170 180 LVHWNSAKYS SAAEAISKAD GLAIIGVLMK VGPANPNLQK VLDALSSVKT KGKRAPFTNF 190 200 210 220 230 240 DPSSLLPSSL DYWTYFGSLT HPPLHESVTW VICKESISLS PEQLAQLRGL LSSAEGEPAV 250 260 PVLSNHRPPQ PLKGRTVRAS F

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: Brown Norway.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: Brown Norway. Tissue: Liver.
[3]	"Proteome profile of the mature rat olfactory bulb." Maurya D.K., Sundaram C.S., Bhargava P. Proteomics 9:2593-2599(2009) [PubMed: 19343716] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.

Cross-references

Sequence databases
EMBL GenBank DDBJ	CH473961 Genomic DNA. Translation: EDM00961.1. BC158888 mRNA. Translation: AAI58889.1.
IPI	IPI00360930.
RefSeq	NP_001101130.1. NM_001107660.1.
UniGene	Rn.6854.
3D structure databases
ProteinModelPortal	B0BNN3.
SMR	B0BNN3. Positions 2-261.
ModBase	Search...
Protein-protein interaction databases
STRING	B0BNN3.
Proteomic databases
PRIDE	B0BNN3.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000014267; ENSRNOP00000014267; ENSRNOG00000010698.
GeneID	310218.
KEGG	rno:310218.
Organism-specific databases
CTD	12346.
RGD	1309780. Car1.
Phylogenomic databases
eggNOG	roNOG06228.
GeneTree	ENSGT00560000076828.
HOVERGEN	HBG002837.
OMA	HNNRPPQ.
OrthoDB	EOG4X97HR.
PhylomeDB	B0BNN3.
Gene expression databases
Genevestigator	B0BNN3.
Family and domain databases
InterPro	IPR001148. a_carbonic_anhydrase. IPR023561. Carbonic_anhydrase_a-class. IPR018338. Carbonic_anhydrase_a-class_CS. IPR018442. Carbonic_anhydrase_CA1. [Graphical view]
Gene3D	G3DSA:3.10.200.10. Euk_COanhd. 1 hit.
KO	K01672.
PANTHER	PTHR18952:SF30. Carbonic_anhydrase_CA1. 1 hit. PTHR18952. Euk_COanhd. 1 hit.
Pfam	PF00194. Carb_anhydrase. 1 hit. [Graphical view]
SMART	SM01057. Carb_anhydrase. 1 hit. [Graphical view]
SUPFAM	SSF51069. Euk_COanhd. 1 hit.
PROSITE	PS00162. ALPHA_CA_1. 1 hit. PS51144. ALPHA_CA_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	661732.

Entry information

Entry name

CAH1_RAT

Accession

Primary (citable) accession number: B0BNN3

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 2, 2008
Last sequence update:	February 26, 2008
Last modified:	January 25, 2012
This is version 34 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program