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Protein

Peptidyl-prolyl cis-trans isomerase

Gene

Pin1

Organism
Rattus norvegicus (Rat)
Status
Unreviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

Peptidylproline (omega=180) = peptidylproline (omega=0).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Isomerase, RotamaseUniRule annotation

Enzyme and pathway databases

BRENDAi5.2.1.8. 5301.
ReactomeiR-RNO-6804756. Regulation of TP53 Activity through Phosphorylation.
R-RNO-6811555. PI5P Regulates TP53 Acetylation.
R-RNO-936440. Negative regulators of RIG-I/MDA5 signaling.

Names & Taxonomyi

Protein namesi
Recommended name:
Peptidyl-prolyl cis-trans isomeraseUniRule annotation (EC:5.2.1.8UniRule annotation)
Gene namesi
Name:Pin1Imported
Synonyms:LOC364561Imported, Pin1_predictedImported
ORF Names:rCG_31594Imported
OrganismiRattus norvegicus (Rat)Imported
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 8

Organism-specific databases

RGDi1310299. Pin1.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: RGD
  • cytosol Source: RGD
  • midbody Source: Ensembl
  • mitochondrion Source: RGD
  • neuron projection Source: RGD
  • nucleus Source: RGD
Complete GO annotation...

Expressioni

Gene expression databases

BgeeiENSRNOG00000020474.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027819.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini5 – 39WWInterPro annotationAdd BLAST35
Domaini54 – 165PpiCInterPro annotationAdd BLAST112

Sequence similaritiesi

Contains 1PpiC domain.UniRule annotation

Phylogenomic databases

eggNOGiKOG3259. Eukaryota.
COG0760. LUCA.
GeneTreeiENSGT00640000091578.
HOGENOMiHOG000275331.
HOVERGENiHBG002101.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG091G0RO7.
TreeFamiTF101101.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

B0BNL2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADEEKLPSG WEKRMSRSSG RVYYFNHITN ASQWERPSGG STVGGGSKNG
60 70 80 90 100
QGEPARVRCS HLLVKHSQSR RPSSWRQEKI TRSKEEALEL INGYIQKIKS
110 120 130 140 150
GEEDFESLAS QFSDCSSAKA RGDLGAFSRG QMQKPFEDAS FALRTGEMSG
160
PVFTDSGIHI ILRTE
Length:165
Mass (Da):18,332
Last modified:February 26, 2008 - v1
Checksum:iCFE809731FF0A518
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069434 Genomic DNA. No translation available.
BC158867 mRNA. Translation: AAI58868.1.
CH473993 Genomic DNA. Translation: EDL78356.1.
RefSeqiNP_001100171.1. NM_001106701.2.
UniGeneiRn.6291.

Genome annotation databases

EnsembliENSRNOT00000027818; ENSRNOP00000027819; ENSRNOG00000020474.
GeneIDi298696.
KEGGirno:298696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AABR07069434 Genomic DNA. No translation available.
BC158867 mRNA. Translation: AAI58868.1.
CH473993 Genomic DNA. Translation: EDL78356.1.
RefSeqiNP_001100171.1. NM_001106701.2.
UniGeneiRn.6291.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000027819.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000027818; ENSRNOP00000027819; ENSRNOG00000020474.
GeneIDi298696.
KEGGirno:298696.

Organism-specific databases

CTDi5300.
RGDi1310299. Pin1.

Phylogenomic databases

eggNOGiKOG3259. Eukaryota.
COG0760. LUCA.
GeneTreeiENSGT00640000091578.
HOGENOMiHOG000275331.
HOVERGENiHBG002101.
KOiK09578.
OMAiDEVQCLH.
OrthoDBiEOG091G0RO7.
TreeFamiTF101101.

Enzyme and pathway databases

BRENDAi5.2.1.8. 5301.
ReactomeiR-RNO-6804756. Regulation of TP53 Activity through Phosphorylation.
R-RNO-6811555. PI5P Regulates TP53 Acetylation.
R-RNO-936440. Negative regulators of RIG-I/MDA5 signaling.

Gene expression databases

BgeeiENSRNOG00000020474.

Family and domain databases

InterProiIPR000297. PPIase_PpiC.
IPR023058. PPIase_PpiC_CS.
IPR001202. WW_dom.
[Graphical view]
PfamiPF00639. Rotamase. 1 hit.
PF00397. WW. 1 hit.
[Graphical view]
SMARTiSM00456. WW. 1 hit.
[Graphical view]
SUPFAMiSSF51045. SSF51045. 1 hit.
PROSITEiPS01096. PPIC_PPIASE_1. 1 hit.
PS50198. PPIC_PPIASE_2. 1 hit.
PS01159. WW_DOMAIN_1. 1 hit.
PS50020. WW_DOMAIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB0BNL2_RAT
AccessioniPrimary (citable) accession number: B0BNL2
Entry historyi
Integrated into UniProtKB/TrEMBL: February 26, 2008
Last sequence update: February 26, 2008
Last modified: November 30, 2016
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.