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B0BNG0 (EMC2_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 45. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name=TPR repeat protein 35
Gene names
Name:Emc2
Synonyms:Ttc35
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length297 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Component of the ER membrane protein complex (EMC) By similarity.

Subcellular location

Nucleus By similarity. Cytoplasm By similarity.

Sequence similarities

Belongs to the EMC2 family.

Contains 3 TPR repeats.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Initiator methionine11Removed By similarity
Chain2 – 297296ER membrane protein complex subunit 2
PRO_0000333731

Regions

Repeat87 – 12034TPR 1
Repeat155 – 18834TPR 2
Repeat192 – 22534TPR 3

Amino acid modifications

Modified residue21N-acetylalanine By similarity

Sequences

Sequence LengthMass (Da)Tools
B0BNG0 [UniParc].

Last modified February 26, 2008. Version 1.
Checksum: 7B8ABD95D4B8A849

FASTA29734,870
        10         20         30         40         50         60 
MAKVTERYDV TWEEMRDKMR KWREENSRNS EQIMEVGEEL INDYASKLGD DIWIIYEQVM 

        70         80         90        100        110        120 
IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM ERYDDAIQLY DRILQEDPTN 

       130        140        150        160        170        180 
TAARKRKIAI RKAQGKNVEA IRELNEYLEQ FVGDQEAWHE LAELYINEHD YAKAAFCLEE 

       190        200        210        220        230        240 
LMMTNPHNHL YCQQYAEVKY TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA 

       250        260        270        280        290 
SNPKASAKMK KDNIRYAGWA ANQINRAYQF AGRSKKETKS SLKAVEDMLE TLQITQS 

« Hide

References

[1]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Liver.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
BC158805 mRNA. Translation: AAI58806.1.
RefSeqNP_001107257.1. NM_001113785.1.
UniGeneRn.203197.

3D structure databases

ProteinModelPortalB0BNG0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000006890.

Proteomic databases

PaxDbB0BNG0.
PRIDEB0BNG0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID362905.
KEGGrno:362905.
UCSCRGD:1310430. rat.

Organism-specific databases

CTD9694.
RGD1310430. Emc2.

Phylogenomic databases

eggNOGNOG236229.
HOGENOMHOG000007547.
HOVERGENHBG055231.
OrthoDBEOG7QK0C9.
PhylomeDBB0BNG0.
TreeFamTF312997.

Gene expression databases

GenevestigatorB0BNG0.

Family and domain databases

Gene3D1.25.40.10. 2 hits.
InterProIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamPF00515. TPR_1. 1 hit.
[Graphical view]
PROSITEPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio681734.
PROB0BNG0.

Entry information

Entry nameEMC2_RAT
AccessionPrimary (citable) accession number: B0BNG0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: April 16, 2014
This is version 45 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families