B0BNG0 (EMC2_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
ER membrane protein complex subunit 2

Alternative name(s):
Tetratricopeptide repeat protein 35
Short name=TPR repeat protein 35

Gene names

Name:	Emc2
Synonyms:	Ttc35

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	297 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Subunit structure	Component of the ER membrane protein complex (EMC) By similarity.
Subcellular location	Nucleus By similarity. Cytoplasm By similarity.
Sequence similarities	Belongs to the EMC2 family. Contains 3 TPR repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Nucleus
Domain	Repeat TPR repeat
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Cellular_component	ER membrane protein complex Inferred from sequence or structural similarity. Source: UniProtKB mitochondrion Inferred from electronic annotation. Source: Compara nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 297	297	ER membrane protein complex subunit 2		PRO_0000333731
Regions
	Repeat	87 – 120	34	TPR 1
	Repeat	155 – 188	34	TPR 2
	Repeat	192 – 225	34	TPR 3

Sequences

	Sequence		Length	Mass (Da)
	B0BNG0 [UniParc]. Last modified February 26, 2008. Version 1. Checksum: 7B8ABD95D4B8A849	FASTA	297	34,870
	10 20 30 40 50 60 MAKVTERYDV TWEEMRDKMR KWREENSRNS EQIMEVGEEL INDYASKLGD DIWIIYEQVM 70 80 90 100 110 120 IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM ERYDDAIQLY DRILQEDPTN 130 140 150 160 170 180 TAARKRKIAI RKAQGKNVEA IRELNEYLEQ FVGDQEAWHE LAELYINEHD YAKAAFCLEE 190 200 210 220 230 240 LMMTNPHNHL YCQQYAEVKY TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA 250 260 270 280 290 SNPKASAKMK KDNIRYAGWA ANQINRAYQF AGRSKKETKS SLKAVEDMLE TLQITQS

References

[1]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Liver.

Cross-references

Sequence databases
EMBL GenBank DDBJ	BC158805 mRNA. Translation: AAI58806.1.
IPI	IPI00366247.
RefSeq	NP_001107257.1. NM_001113785.1.
UniGene	Rn.203197.
3D structure databases
ProteinModelPortal	B0BNG0.
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000006890.
Proteomic databases
PaxDb	B0BNG0.
PRIDE	B0BNG0.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	362905.
KEGG	rno:362905.
UCSC	RGD:1310430. rat.
Organism-specific databases
CTD	9694.
RGD	1310430. Emc2.
Phylogenomic databases
eggNOG	NOG236229.
HOGENOM	HOG000007547.
HOVERGEN	HBG055231.
OMA	YGKAAFC.
OrthoDB	EOG41ZFBF.
Gene expression databases
Genevestigator	B0BNG0.
Family and domain databases
Gene3D	1.25.40.10. 2 hits.
InterPro	IPR001440. TPR-1. IPR013026. TPR-contain_dom. IPR011990. TPR-like_helical. IPR013105. TPR_2. IPR019734. TPR_repeat. [Graphical view]
Pfam	PF00515. TPR_1. 1 hit. PF07719. TPR_2. 1 hit. [Graphical view]
PROSITE	PS50005. TPR. 2 hits. PS50293. TPR_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	681734.

Entry information

Entry name

EMC2_RAT

Accession

Primary (citable) accession number: B0BNG0

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 20, 2008
Last sequence update:	February 26, 2008
Last modified:	May 1, 2013
This is version 39 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program