Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

B0BNG0

- EMC2_RAT

UniProt

B0BNG0 - EMC2_RAT

Protein

ER membrane protein complex subunit 2

Gene

Emc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 46 (01 Oct 2014)
      Sequence version 1 (26 Feb 2008)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    ER membrane protein complex subunit 2
    Alternative name(s):
    Tetratricopeptide repeat protein 35
    Short name:
    TPR repeat protein 35
    Gene namesi
    Name:Emc2
    Synonyms:Ttc35
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi1310430. Emc2.

    Subcellular locationi

    Nucleus By similarity. Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. endoplasmic reticulum Source: UniProtKB
    3. ER membrane protein complex Source: UniProtKB
    4. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 297296ER membrane protein complex subunit 2PRO_0000333731Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiB0BNG0.
    PRIDEiB0BNG0.

    Expressioni

    Gene expression databases

    GenevestigatoriB0BNG0.

    Interactioni

    Subunit structurei

    Component of the ER membrane protein complex (EMC).By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000006890.

    Structurei

    3D structure databases

    ProteinModelPortaliB0BNG0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati87 – 12034TPR 1Add
    BLAST
    Repeati155 – 18834TPR 2Add
    BLAST
    Repeati192 – 22534TPR 3Add
    BLAST

    Sequence similaritiesi

    Belongs to the EMC2 family.Curated
    Contains 3 TPR repeats.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat, TPR repeat

    Phylogenomic databases

    eggNOGiNOG236229.
    HOGENOMiHOG000007547.
    HOVERGENiHBG055231.
    OrthoDBiEOG7QK0C9.
    PhylomeDBiB0BNG0.
    TreeFamiTF312997.

    Family and domain databases

    Gene3Di1.25.40.10. 2 hits.
    InterProiIPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view]
    PfamiPF00515. TPR_1. 1 hit.
    [Graphical view]
    PROSITEiPS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    B0BNG0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAKVTERYDV TWEEMRDKMR KWREENSRNS EQIMEVGEEL INDYASKLGD    50
    DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM 100
    ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKNVEA IRELNEYLEQ 150
    FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY 200
    TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKMK 250
    KDNIRYAGWA ANQINRAYQF AGRSKKETKS SLKAVEDMLE TLQITQS 297
    Length:297
    Mass (Da):34,870
    Last modified:February 26, 2008 - v1
    Checksum:i7B8ABD95D4B8A849
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC158805 mRNA. Translation: AAI58806.1.
    RefSeqiNP_001107257.1. NM_001113785.1.
    UniGeneiRn.203197.

    Genome annotation databases

    GeneIDi362905.
    KEGGirno:362905.
    UCSCiRGD:1310430. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    BC158805 mRNA. Translation: AAI58806.1 .
    RefSeqi NP_001107257.1. NM_001113785.1.
    UniGenei Rn.203197.

    3D structure databases

    ProteinModelPortali B0BNG0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000006890.

    Proteomic databases

    PaxDbi B0BNG0.
    PRIDEi B0BNG0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 362905.
    KEGGi rno:362905.
    UCSCi RGD:1310430. rat.

    Organism-specific databases

    CTDi 9694.
    RGDi 1310430. Emc2.

    Phylogenomic databases

    eggNOGi NOG236229.
    HOGENOMi HOG000007547.
    HOVERGENi HBG055231.
    OrthoDBi EOG7QK0C9.
    PhylomeDBi B0BNG0.
    TreeFami TF312997.

    Miscellaneous databases

    NextBioi 681734.
    PROi B0BNG0.

    Gene expression databases

    Genevestigatori B0BNG0.

    Family and domain databases

    Gene3Di 1.25.40.10. 2 hits.
    InterProi IPR013026. TPR-contain_dom.
    IPR011990. TPR-like_helical.
    IPR001440. TPR_1.
    IPR019734. TPR_repeat.
    [Graphical view ]
    Pfami PF00515. TPR_1. 1 hit.
    [Graphical view ]
    PROSITEi PS50005. TPR. 2 hits.
    PS50293. TPR_REGION. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Liver.

    Entry informationi

    Entry nameiEMC2_RAT
    AccessioniPrimary (citable) accession number: B0BNG0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 20, 2008
    Last sequence update: February 26, 2008
    Last modified: October 1, 2014
    This is version 46 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3