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Protein

ER membrane protein complex subunit 2

Gene

Emc2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
ER membrane protein complex subunit 2
Alternative name(s):
Tetratricopeptide repeat protein 35
Short name:
TPR repeat protein 35
Gene namesi
Name:Emc2
Synonyms:Ttc35
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi1310430. Emc2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 297296ER membrane protein complex subunit 2PRO_0000333731Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiB0BNG0.
PRIDEiB0BNG0.

Expressioni

Gene expression databases

GenevisibleiB0BNG0. RN.

Interactioni

Subunit structurei

Component of the ER membrane protein complex (EMC).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006890.

Structurei

3D structure databases

ProteinModelPortaliB0BNG0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati87 – 12034TPR 1Add
BLAST
Repeati155 – 18834TPR 2Add
BLAST
Repeati192 – 22534TPR 3Add
BLAST

Sequence similaritiesi

Belongs to the EMC2 family.Curated
Contains 3 TPR repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, TPR repeat

Phylogenomic databases

eggNOGiNOG236229.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiB0BNG0.
OrthoDBiEOG7QK0C9.
PhylomeDBiB0BNG0.
TreeFamiTF312997.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

B0BNG0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKVTERYDV TWEEMRDKMR KWREENSRNS EQIMEVGEEL INDYASKLGD
60 70 80 90 100
DIWIIYEQVM IAALDYGRDD LALFCLQELR RQFPGSHRVK RLTGMRFEAM
110 120 130 140 150
ERYDDAIQLY DRILQEDPTN TAARKRKIAI RKAQGKNVEA IRELNEYLEQ
160 170 180 190 200
FVGDQEAWHE LAELYINEHD YAKAAFCLEE LMMTNPHNHL YCQQYAEVKY
210 220 230 240 250
TQGGLENLEL SRKYFAQALK LNNRNMRALF GLYMSASHIA SNPKASAKMK
260 270 280 290
KDNIRYAGWA ANQINRAYQF AGRSKKETKS SLKAVEDMLE TLQITQS
Length:297
Mass (Da):34,870
Last modified:February 26, 2008 - v1
Checksum:i7B8ABD95D4B8A849
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158805 mRNA. Translation: AAI58806.1.
RefSeqiNP_001107257.1. NM_001113785.1.
UniGeneiRn.203197.

Genome annotation databases

GeneIDi362905.
KEGGirno:362905.
UCSCiRGD:1310430. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC158805 mRNA. Translation: AAI58806.1.
RefSeqiNP_001107257.1. NM_001113785.1.
UniGeneiRn.203197.

3D structure databases

ProteinModelPortaliB0BNG0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006890.

Proteomic databases

PaxDbiB0BNG0.
PRIDEiB0BNG0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi362905.
KEGGirno:362905.
UCSCiRGD:1310430. rat.

Organism-specific databases

CTDi9694.
RGDi1310430. Emc2.

Phylogenomic databases

eggNOGiNOG236229.
HOGENOMiHOG000007547.
HOVERGENiHBG055231.
InParanoidiB0BNG0.
OrthoDBiEOG7QK0C9.
PhylomeDBiB0BNG0.
TreeFamiTF312997.

Miscellaneous databases

NextBioi681734.
PROiB0BNG0.

Gene expression databases

GenevisibleiB0BNG0. RN.

Family and domain databases

Gene3Di1.25.40.10. 2 hits.
InterProiIPR013026. TPR-contain_dom.
IPR011990. TPR-like_helical_dom.
IPR001440. TPR_1.
IPR019734. TPR_repeat.
[Graphical view]
PfamiPF00515. TPR_1. 1 hit.
[Graphical view]
PROSITEiPS50005. TPR. 2 hits.
PS50293. TPR_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Liver.

Entry informationi

Entry nameiEMC2_RAT
AccessioniPrimary (citable) accession number: B0BNG0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: February 26, 2008
Last modified: June 24, 2015
This is version 52 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.